anti-Factor VIII Antibodies

Protein Summary

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Gene names and symbols associated with F8

• coagulation factor VIIi (f7i) antibody
• coagulation factor VIII (F8) antibody
• coagulation factor VIII, procoagulant component (F8) antibody

• AHF antibody
• Cf-8 antibody
• Cf8 antibody
• DXS1253E antibody
• F8B antibody
• Show all synonym aliases
• F8C antibody
• fb61d02 antibody
• FVIII antibody
• HEMA antibody
• wu:fb61d02 antibody

Protein level used designations for F8

Factor VIII , procoagulant component , antihemophilic factor , coagulation factor VIII , coagulation factor VIIIc , factor VIII F8B , coagulation factor VIII, procoagulant component (hemophilia A) , factor VIII , coagulation co-factor