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estrogen regulated gene; overexpression correlates with mammary carcinogenesis. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal CCD80 Primary Antibody for IHC, IHC (p) - ABIN4364457
Asplund, Gry Björklund, Sundquist, Strömberg, Edlund, Ostman, Nilsson, Pontén, Lundeberg: Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma. in The British journal of dermatology 2008
Our finding of upregulated CCDC80 expression in the visceral adipose tissue of obese patients indicates that it may be a component of the obesity-altered secretome in this depot. Furthermore, the presence of CCDC80 protein in human serum and its association with systemic metabolic dysfunction suggests that it may be linked to metabolic changes in other organs.
Ccdc80 is a novel betacat-regulated gene in adrenocortical cells
activation of PKGI with cGMP regulated SSG1 intracellular distribution.
Data suggest that CCDC80 expression is down-regulated in many thyroid carcinomas; loss of heterozygosity partially accounts for CCDC80 down-regulation in thyroid carcinoma; CCDC80 expression positively regulates expression of E-cadherin.
The CCDC80 protein has three P-DUDES structural domains. These domains have significant albeit remote sequence similarity to thioredoxin-like domains and are predicted to have an oxidoreductase function.
Results reveal DRO1 as an AIB1-targeted tumor suppressor, providing a novel mechanism for AIB1-dependent inhibition of apoptosis.
Downregulated during osteoblastic differentiation of bone marrow stromal cells. Suggests role in skeletogenesis.
URB is expressed in human dermal papilla cells
In conclusion, the expression pattern of URB suggests its role in obesity and the results suggest that URB is secreted, at least in part, from adipocytes.
DRO1 is a crucial regulator of energy homeostasis in vivo and functions as an inhibitor of adipogenesis in primary cells.
This report characterizes a new mouse model for the study of colorectal cancer and establishes DRO1 (CCDC80) as a tumor suppressor via a mechanism involving ERK phosphorylation.
Data indicate that embryonic fibroblasts from cl2/coiled-coil domain-containing protein 80 (ccdc80) knock-out mice showed higher proliferation rate and lower susceptibility to apoptosis.
Results suggest that Ccdc80 is a novel modulator of glucose and energy homeostasis during diet-induced obesity.
Ccdc80 plays dual roles in adipogenesis by mechanisms that involve at least in part down-regulation of Wnt/beta-catenin signaling and induction of C/EBPalpha and peroxisome proliferator-activated receptor gamma.
investigated the functional effects of Coiled-Coil Domain Containing 80-loss-of-function during embryonic development and verified its interaction with gadd45beta2 in somitogenesis
analysis of zebrafish Ccdc80 and Ccdc80-like1 (Ccdc80-l1) proteins; Ccdc80-l1 is involved in axon pathfinding of zebrafish motoneurons
estrogen regulated gene; overexpression correlates with mammary carcinogenesis
coiled-coil domain containing 80
, steroid-sensitive protein 1
, coiled-coil domain-containing protein 80-like
, coiled-coil domain-containing protein 80
, down-regulated by oncogenes protein 1
, nuclear envelope protein okuribin
, steroid sensitive gene 1
, up-regulated in BRS-3 deficient mouse homolog
, down-regulated by oncogenes 1 protein
, steroid sensitive gene-1 protein
, steroid-sensitive gene 1 protein
, coiled-coil domain-containing protein 80oiled-coil domain-containing protein 80
, up-regulated in BRS-3 deficient mouse