Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 Proteins (CHCHD4)

CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008].. Additionally we are shipping CHCHD4 Antibodies (56) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHCHD4 72170 Q8VEA4
CHCHD4 131474 Q8N4Q1
CHCHD4 312559 Q5BJN5
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Top CHCHD4 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Log in to see 11 Days
$411.40
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,289.83
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,297.17
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,297.17
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,297.17
Details

CHCHD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

More Proteins for Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) Interaction Partners

Mouse (Murine) Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) interaction partners

  1. To test whether differences in the ratio between CHCHD4 and ALR might explain tissue-specific differences in the CHCHD4 redox state, we determined the molar ratio of both proteins in different mouse tissues. Surprisingly, ALR is superstoichiometric over CHCHD4 in most tissues.

  2. These results suggest that CHCHD4 haploinsufficiency afforded persistent neuroprotection related to reduced release of mitochondrial intermembrane space proteins.

  3. Mechanistically, exercise-induced nuclear transcription factor FOXO3 binds to the CHCHD4 promoter and represses its expression, preventing the translocation of p53 to the mitochondria and thereby increasing p53 nuclear localization.

Human Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) interaction partners

  1. First group to discover the expression of the human CHCHD4 isoforms and first to call the human gene CHCHD4, and to clone and show the expression of its alternatively expressed CHCHD4 isoforms (CHCHD4.1 and CHCHD4.2).

  2. Compared to wild type control littermates, mice with a knockout of CHCHD4 exhibit reduced weight gain when fed a high-fat diet.

  3. Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1) in the cytoplasm were directly observed with in-cell NMR spectroscopy.

  4. our findings suggest that MIA40 reduction contributes to the effects of AIF deficiency on OXPHOS, as it may impact on the correct assembly and maintenance of the respiratory subunits.

  5. results demonstrate an indispensable role for hMIA40 for the export of Fe-S clusters from mitochondria.

  6. Data indicate that poptosis-inducing factor (AIF) controls the mitochondrial import of mitochondrial membrane transport protein CHCHD4.

  7. In aggregate these data suggest that the Mia40/lfALR system has a broad sequence specificity and that potential substrates may be protected from adventitious oxidation by kinetic sequestration within the mitochondrial IMS.

  8. Import and oxidative folding of proteins are kinetically and functionally coupled and depend on the expression of Mia40, ALR, and the intracellular glutathione pool.

  9. Data indicate that decreased CHCHD4 expression prevents the mitochondrial translocation of p53 while augmenting its nuclear localization and activity.

  10. illustrate a very atypical behaviour for the Mia40 precursor compared to other substrates of the MIA pathway. By contrast, interaction with Erv1 occurs after 5 min of import and relies on a more stringent specificity

  11. mitochondrial localization of MIA40 requires sulfhydryl oxidase ALR in heterologous expression yeast system.

  12. Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR.

  13. biogenesis and function of MIA40 in the mitochondrial intermembrane space is dependent on redox processes involving conserved cysteine residues

  14. After passage across the translocase of the mitochondrial outer membrane Erv1 interacts via disulfide bonds with Mia40.

  15. analysis of how mitochondrial biogenesis switches the sorting pathway of the intermembrane space receptor Mia40

  16. Catalysis involves a flow of reducing equivalents from the reduced CxC cysteine motif of Mia40 to distal and then proximal CxxC motifs of long-form ALR to the flavin ring and, finally, to cytochrome c or molecular oxygen.

CHCHD4 Protein Profile

Protein Summary

CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005

Gene names and symbols associated with CHCHD4

  • coiled-coil-helix-coiled-coil-helix domain containing 4 (Chchd4)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 (CHCHD4)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 (chchd4)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 L homeolog (chchd4.L)
  • coiled-coil-helix-coiled-coil-helix domain containing 4a (chchd4a)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 S homeolog (chchd4.S)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 (LOC100361898)
  • Mia40p (MIA40)
  • 2410012P20Rik protein
  • 2810014D17Rik protein
  • AI838740 protein
  • CaO19.2977 protein
  • chchd4 protein
  • chchd4a protein
  • chchd4b protein
  • fc10g04 protein
  • mia40 protein
  • si:dkey-202e22.1 protein
  • timm40 protein
  • wu:fc10g04 protein
  • zgc:100849 protein

Protein level used designations for CHCHD4

coiled-coil-helix-coiled-coil-helix domain-containing protein 4 , mitochondrial intermembrane space import and assembly protein 40 , mitochondrial intermembrane space import and assembly 40 homolog , translocase of inner mitochondrial membrane 40 homolog , mitochondrial intermembrane space import and assembly protein 40-A , coiled-coil-helix-coiled-coil-helix domain-containing protein 4-A , coiled-coil-helix-coiled-coil-helix domain containing 4 , mitochondrial intermembrane space import and assembly protein 40-B , coiled-coil-helix-coiled-coil-helix domain-containing protein 4-B , Mitochondrial import inner membrane translocase TIM40

GENE ID SPECIES
72170 Mus musculus
131474 Homo sapiens
312559 Rattus norvegicus
394473 Xenopus (Silurana) tropicalis
414630 Xenopus laevis
416037 Gallus gallus
445144 Danio rerio
470755 Pan troglodytes
494790 Xenopus laevis
513889 Bos taurus
700814 Macaca mulatta
100224104 Taeniopygia guttata
100361898 Rattus norvegicus
476520 Canis lupus familiaris
100723885 Cavia porcellus
3636866 Candida albicans SC5314
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