Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 Proteins (CHCHD4)

CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008].. Additionally we are shipping CHCHD4 Antibodies (53) and and many more products for this protein.

Gene Name	GeneID	UniProt
CHCHD4	72170	Q8VEA4
CHCHD4	131474	Q8N4Q1
CHCHD4	312559	Q5BJN5

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Top CHCHD4 Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No.	Origin	Source	Conjugate	Quantity	Supplier	Delivery	Price	Details
ABIN3083650	Insect Cells	Human	His tag	1 mg	Log in to see	50 Days	$6,869.04	Details
ABIN3127063	Insect Cells	Mouse	His tag	1 mg	Log in to see	50 Days	$6,869.04	Details
ABIN5711676	Escherichia coli (E. coli)	Human	His-SUMO Tag	100 μg	Log in to see	11 Days	$411.40	Details
ABIN2713955	HEK-293 Cells	Human	Myc-DYKDDDDK Tag	20 μg	Log in to see	Available	$814.00	Details
ABIN1349283	Wheat germ	Human	GST tag	10 μg	Log in to see	11 to 12 Days	$414.29	Details
ABIN1622053	Yeast	Cow	His tag	1 mg	Log in to see	60 to 71 Days	$2,289.83	Details
ABIN1633523	Yeast	Rat	His tag	1 mg	Log in to see	60 to 71 Days	$2,297.17	Details
ABIN1674376	Yeast	Xenopus tropicalis	His tag	1 mg	Log in to see	60 to 71 Days	$2,297.17	Details
ABIN1634423	Yeast	Xenopus laevis	His tag	1 mg	Log in to see	60 to 71 Days	$2,297.17	Details

CHCHD4 Proteins by Origin and Source

Origin	Expressed in	Conjugate
Mouse (Murine)
Human	, , ,	, , ,
Rat (Rattus)

More product categories related to CHCHD4 Protein

More Proteins for Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) Interaction Partners

Mouse (Murine) Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) interaction partners

To test whether differences in the ratio between CHCHD4 and ALR (show GFER Proteins) might explain tissue-specific differences in the CHCHD4 redox state, we determined the molar ratio of both proteins in different mouse tissues. Surprisingly, ALR (show GFER Proteins) is superstoichiometric over CHCHD4 in most tissues.
These results suggest that CHCHD4 haploinsufficiency afforded persistent neuroprotection related to reduced release of mitochondrial intermembrane space proteins.
Mechanistically, exercise-induced nuclear transcription factor FOXO3 (show FOXO3 Proteins) binds to the CHCHD4 promoter and represses its expression, preventing the translocation of p53 (show TP53 Proteins) to the mitochondria and thereby increasing p53 (show TP53 Proteins) nuclear localization.

Human Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) interaction partners

First group to discover the expression of the human CHCHD4 isoforms and first to call the human gene CHCHD4, and to clone and show the expression of its alternatively expressed CHCHD4 isoforms (CHCHD4.1 and CHCHD4.2).
Compared to wild type control littermates, mice with a knockout of CHCHD4 exhibit reduced weight gain when fed a high-fat diet.
Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17 (show COX17 Proteins)), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1 (show SOD1 Proteins)) in the cytoplasm were directly observed with in-cell NMR spectroscopy.
our findings suggest that MIA40 reduction contributes to the effects of AIF (show AIFM1 Proteins) deficiency on OXPHOS, as it may impact on the correct assembly and maintenance of the respiratory subunits.
Data indicate that poptosis-inducing factor (AIF (show AIFM1 Proteins)) controls the mitochondrial import of mitochondrial membrane transport protein CHCHD4.
In aggregate these data suggest that the Mia40/lfALR system has a broad sequence specificity and that potential substrates may be protected from adventitious oxidation by kinetic sequestration within the mitochondrial IMS.
Import and oxidative folding of proteins are kinetically and functionally coupled and depend on the expression of Mia40, ALR (show GFER Proteins), and the intracellular glutathione pool.
Data indicate that decreased CHCHD4 expression prevents the mitochondrial translocation of p53 (show TP53 Proteins) while augmenting its nuclear localization and activity.
illustrate a very atypical behaviour for the Mia40 precursor compared to other substrates of the MIA (show MIA Proteins) pathway. By contrast, interaction with Erv1 (show GFER Proteins) occurs after 5 min of import and relies on a more stringent specificity
mitochondrial localization of MIA40 requires sulfhydryl oxidase ALR (show GFER Proteins) in heterologous expression yeast system.

CHCHD4 Protein Profile

Protein Summary

Gene names and symbols associated with CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4 (Chchd4)
coiled-coil-helix-coiled-coil-helix domain containing 4 (CHCHD4)
coiled-coil-helix-coiled-coil-helix domain containing 4 (chchd4)
coiled-coil-helix-coiled-coil-helix domain containing 4 L homeolog (chchd4.L)
coiled-coil-helix-coiled-coil-helix domain containing 4a (chchd4a)
coiled-coil-helix-coiled-coil-helix domain containing 4 S homeolog (chchd4.S)
coiled-coil-helix-coiled-coil-helix domain containing 4 (LOC100361898)
Mia40p (MIA40)

2410012P20Rik protein
2810014D17Rik protein
AI838740 protein
CaO19.2977 protein
chchd4 protein
chchd4a protein
chchd4b protein
fc10g04 protein
mia40 protein
si:dkey-202e22.1 protein
timm40 protein
wu:fc10g04 protein
zgc:100849 protein

Protein level used designations for CHCHD4

coiled-coil-helix-coiled-coil-helix domain-containing protein 4 , mitochondrial intermembrane space import and assembly protein 40 , mitochondrial intermembrane space import and assembly 40 homolog , translocase of inner mitochondrial membrane 40 homolog , mitochondrial intermembrane space import and assembly protein 40-A , coiled-coil-helix-coiled-coil-helix domain-containing protein 4-A , coiled-coil-helix-coiled-coil-helix domain containing 4 , mitochondrial intermembrane space import and assembly protein 40-B , coiled-coil-helix-coiled-coil-helix domain-containing protein 4-B , Mitochondrial import inner membrane translocase TIM40

GENE ID	SPECIES
72170	Mus musculus
131474	Homo sapiens
312559	Rattus norvegicus
394473	Xenopus (Silurana) tropicalis
414630	Xenopus laevis
416037	Gallus gallus
445144	Danio rerio
470755	Pan troglodytes
494790	Xenopus laevis
513889	Bos taurus
700814	Macaca mulatta
100224104	Taeniopygia guttata
100361898	Rattus norvegicus
476520	Canis lupus familiaris
100723885	Cavia porcellus
3636866	Candida albicans SC5314

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