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Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Additionally we are shipping Collagen, Type III Kits (69) and Collagen, Type III Proteins (13) and many more products for this protein.
Showing 10 out of 187 products:
Human Polyclonal COL3 Primary Antibody for IF (p), IHC (p) - ABIN669981
Zhu, Hu, Yu, Ren, Hu: High Molecular Weight Hyaluronic Acid Inhibits Fibrosis of Endometrium. in Medical science monitor : international medical journal of experimental and clinical research 2016
Show all 6 Pubmed References
Human Polyclonal COL3 Primary Antibody for ELISA - ABIN135050
Karamichos, Hutcheon, Zieske: Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model. in Journal of tissue engineering and regenerative medicine 2011
Show all 6 Pubmed References
Human Polyclonal COL3 Primary Antibody for IHC (fro), IHC (p) - ABIN2473051
Tauler, Lange, el-Maghrabi, Pilkis: Expression of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and its kinase domain in Escherichia coli. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Polyclonal COL3 Primary Antibody for ELISA, ICC - ABIN6260941
Yang, Zhou, Zhu, Fan, Liu, Duan, Tang, Shou, Zuo: miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition. in Journal of gastroenterology and hepatology 2018
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Rat (Rattus) Polyclonal COL3 Primary Antibody for IHC (fro), IF - ABIN2473053
Jones, Bigley, Pemberton, Randall et al.: Quantitative histopathological assessment of retardation of islets of langerhans degeneration in rosiglitazone-dosed obese ZDF rats using combined insulin and collagens (I and III) ... in Toxicologic pathology 2013
Human Polyclonal COL3 Primary Antibody for IF (p), IHC (p) - ABIN730168
Hu, Zeng, Jiang, Hu, Meng, Zhu, Mao: The expression of marker for endometrial stem cell and fibrosis was increased in intrauterine adhesious. in International journal of clinical and experimental pathology 2015
Cow (Bovine) Polyclonal COL3 Primary Antibody for ELISA, IHC - ABIN214580
Jeong, Luo, Li, Strokes, Piao: Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. in The Journal of comparative neurology 2012
Human Polyclonal COL3 Primary Antibody for ICC, IHC (fro) - ABIN1172519
Li, Kong, Ma, Gao, Ma: Uighur medicine abnormal savda munzip (ASMq) suppresses expression of collagen and TGF-β1 with concomitant induce Smad7 in human hypertrophic scar fibroblasts. in International journal of clinical and experimental medicine 2015
digestion of thrombin (show F2 Antibodies) by P. aeruginosa elastase leads to the release of the C-terminal thrombin (show F2 Antibodies)-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns.
Prothrombin (show F2 Antibodies) gene mutation is rare in Budd-Chiari syndrome patients in India.
In HBV-related cirrhosis, the combination of miR (show MLXIP Antibodies)-122, AFP (show AFP Antibodies) and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
Data, including data using network analysis, suggest that angiotensinogen (AGT (show AGT Antibodies)), mitogen-activated protein kinase-14 (MAPK14 (show MAPK14 Antibodies)), and prothrombin (show F2 Antibodies) (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
Arg596Gln mutation is a risk factor for Chinese patients with venous thromboembolism due to its moderately decreased clotting activity but strong resistance to antithrombin (show SERPINC1 Antibodies) inhibition.
The induction of TG by BXPC3 cells was mainly driven by the TF pathway while TG generation triggered by MCF7 cells was also driven by FXII (show F12 Antibodies) activation.
we were not able to confirm the association between the polymorphisms of f5, f2, and mthfr (show MTHFR Antibodies) and pregnancy loss in Bosnian women
Platelets were activated in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients, and such activation was at least partially attributed to the thrombin (show F2 Antibodies)-protease-activated receptors (PARs (show EPRS Antibodies)) pathway.
The meta-analysis enabled us to underline the importance of DCP (show ACE Antibodies) in the refinement of the eligibility criteria of hepatocellular cancer (HCC (show FAM126A Antibodies))patients for liver transplant (LT). This information, based on Japanese studies performed in the setting of living-donor LT only, needs further validation in the Western world both in the setting of post-mortem and living-donor LT.
HCC (show FAM126A Antibodies) [hepatocellular carcinoma] patients who are sero-positive for DCP (show ACE Antibodies) [Des (show DES Antibodies)-gamma-carboxyprothrombin] and sero-negative for AFP (show AFP Antibodies)[Alpha-fetoprotein (show AFP Antibodies)] have significantly higher levels of serum ALT[alanine aminotransferase (show ALT Antibodies)]; serum ALT levels may be of diagnostic importance in AFP (show AFP Antibodies)-negative, HBV-related HCC (show FAM126A Antibodies) [hepatitis B virus-related hepatocellular carcinoma] patients.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin (show F2 Antibodies) generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin (show F2 Antibodies)-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin (show F2 Antibodies) carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (show BGN Antibodies) plays a protective role during the progression of atherosclerosis in ApoE (show APOE Antibodies)-deficient mice by inhibiting thrombin (show F2 Antibodies) generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (show GP1BA Antibodies)-binding and heparin-binding site of thrombin (show F2 Antibodies)
thrombin (show F2 Antibodies)/PAR-1 (show MARK2 Antibodies) interaction regulated MCP-1 (show CPT1B Antibodies), TF, MCSF (show CSF1 Antibodies) and IL-6 (show IL6 Antibodies) production.
Observations illustrate the role of thrombin (show F2 Antibodies) as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 Antibodies) nanoparticle therapeutics.
Thrombin (show F2 Antibodies)-PAR1 (show F2R Antibodies) signaling, via nitric oxide and EPCR (show PROCR Antibodies), promotes hematopoietic stem cell (HSC (show FUT1 Antibodies)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin (show F2 Antibodies) promotes sustained signaling and inflammatory gene expression through the CDC25 (show CDC25C Antibodies) and Ras-associating domains of phospholipase C epsilon (show PLCE1 Antibodies).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2