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Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Additionally we are shipping Collagen, Type III Kits (69) and Collagen, Type III Proteins (13) and many more products for this protein.
Showing 10 out of 172 products:
Human Polyclonal COL3 Primary Antibody for IF (p), IHC (p) - ABIN669981
Zhu, Hu, Yu, Ren, Hu: High Molecular Weight Hyaluronic Acid Inhibits Fibrosis of Endometrium. in Medical science monitor : international medical journal of experimental and clinical research 2016
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Human Polyclonal COL3 Primary Antibody for ELISA - ABIN135050
Karamichos, Hutcheon, Zieske: Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model. in Journal of tissue engineering and regenerative medicine 2011
Show all 6 Pubmed References
Human Polyclonal COL3 Primary Antibody for IHC (fro), IHC (p) - ABIN2473051
Tauler, Lange, el-Maghrabi, Pilkis: Expression of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and its kinase domain in Escherichia coli. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Polyclonal COL3 Primary Antibody for ELISA, ICC - ABIN6260941
Yang, Zhou, Zhu, Fan, Liu, Duan, Tang, Shou, Zuo: miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition. in Journal of gastroenterology and hepatology 2018
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Rat (Rattus) Polyclonal COL3 Primary Antibody for IHC (fro), IF - ABIN2473053
Jones, Bigley, Pemberton, Randall et al.: Quantitative histopathological assessment of retardation of islets of langerhans degeneration in rosiglitazone-dosed obese ZDF rats using combined insulin and collagens (I and III) ... in Toxicologic pathology 2013
Human Polyclonal COL3 Primary Antibody for ICC, IHC (fro) - ABIN1172519
Li, Kong, Ma, Gao, Ma: Uighur medicine abnormal savda munzip (ASMq) suppresses expression of collagen and TGF-β1 with concomitant induce Smad7 in human hypertrophic scar fibroblasts. in International journal of clinical and experimental medicine 2015
Cow (Bovine) Polyclonal COL3 Primary Antibody for ELISA, IHC - ABIN214580
Jeong, Luo, Li, Strokes, Piao: Characterization of G protein-coupled receptor 56 protein expression in the mouse developing neocortex. in The Journal of comparative neurology 2012
Human Polyclonal COL3 Primary Antibody for IF (p), IHC (p) - ABIN730168
Hu, Zeng, Jiang, Hu, Meng, Zhu, Mao: The expression of marker for endometrial stem cell and fibrosis was increased in intrauterine adhesious. in International journal of clinical and experimental pathology 2015
This study proved that Berberine (BBR) is a direct thrombin (show F2 Antibodies) inhibitor that has activity in inhibiting thrombin (show F2 Antibodies)-induced platelet aggregation. BBR may be a potential candidate for the development of safe and effective thrombin (show F2 Antibodies)-inhibiting drugs
Thrombin (show F2 Antibodies) generation had a limited impact as biomarker of venous thromboembolism.
Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.
the prothrombotic activity of FII is the result of a polymorphism and of a missense mutation, whereas that of FV derives only from a polymorphism. The observation that a clotting factor (show F7 Antibodies) defect may be associated with both bleeding or venous thrombosis depending on the site of the mutation has caused an extensive reevaluation of the blood clotting mechanism.
Findings provide evidence for a relationship between two genes-three mutations-of the cardiovascular disease (CVD genes panel and recurrent pregnancy loss (RPL). These genotypes include the heterozygous state of the factor II G20210A mutation.
digestion of thrombin (show F2 Antibodies) by P. aeruginosa elastase leads to the release of the C-terminal thrombin (show F2 Antibodies)-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns.
Prothrombin (show F2 Antibodies) gene mutation is rare in Budd-Chiari syndrome patients in India.
In HBV-related cirrhosis, the combination of miR (show MLXIP Antibodies)-122, AFP (show AFP Antibodies) and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
Data, including data using network analysis, suggest that angiotensinogen (AGT (show AGT Antibodies)), mitogen-activated protein kinase-14 (MAPK14 (show MAPK14 Antibodies)), and prothrombin (show F2 Antibodies) (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
Arg596Gln mutation is a risk factor for Chinese patients with venous thromboembolism due to its moderately decreased clotting activity but strong resistance to antithrombin (show SERPINC1 Antibodies) inhibition.
These results suggested that the thrombinstimulated synthesis of IL6 (show IL6 Antibodies) was limited by HSP90 (show HSP90 Antibodies) in osteoblasts, and that the effects of HSP90 (show HSP90 Antibodies) were exerted at the point between Rhokinase and p38 MAPK (show MAPK14 Antibodies).
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin (show F2 Antibodies) generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin (show F2 Antibodies)-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin (show F2 Antibodies) carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (show BGN Antibodies) plays a protective role during the progression of atherosclerosis in ApoE (show APOE Antibodies)-deficient mice by inhibiting thrombin (show F2 Antibodies) generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (show GP1BA Antibodies)-binding and heparin-binding site of thrombin (show F2 Antibodies)
thrombin (show F2 Antibodies)/PAR-1 (show MARK2 Antibodies) interaction regulated MCP-1 (show CPT1B Antibodies), TF, MCSF (show CSF1 Antibodies) and IL-6 (show IL6 Antibodies) production.
Observations illustrate the role of thrombin (show F2 Antibodies) as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 Antibodies) nanoparticle therapeutics.
Thrombin (show F2 Antibodies)-PAR1 (show F2R Antibodies) signaling, via nitric oxide and EPCR (show PROCR Antibodies), promotes hematopoietic stem cell (HSC (show FUT1 Antibodies)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2