Collagen, Type IV, alpha 2 Proteins (COL4a2)

COL4a2 encodes one of the six subunits of type IV collagen, the major structural component of basement membranes.

list all proteins Gene Name GeneID UniProt
Human COL4a2 COL4a2 1284 P08572
Mouse COL4a2 COL4a2 12827 P08122
Rat COL4a2 COL4a2 306628  
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Top COL4a2 Proteins at antibodies-online.com

Showing 4 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$669.00
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Escherichia coli (E. coli) Human His tag 50 μg Log in to see 13 to 16 Days
$242.00
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More Proteins for Collagen, Type IV, alpha 2 (COL4a2) Interaction Partners

Human Collagen, Type IV, alpha 2 (COL4a2) interaction partners

  1. Herein, we describe a large family of first-degree relatives affected by a novel heterozygous variant in COL4A2 (c.3490G.A).

  2. Data showed that Col4A2 can restrain triple-negative breast cancer (TNBC) cell lines MDA-MB-231 and MDA-MB-468 proliferation, migration, cell cycle, and ultimately lead to apoptosis. The data indicated that Col4A2 was significantly correlated with the proliferation and invasive potential of TNBC.

  3. In this study, the inhibitory effect of recombinant canstatin on tumour growth was investigated using a gastric cancer xenograft model.

  4. Genotype-phenotype correlations in pathology caused by COL4A1 (show COL4A1 Proteins) and COL4A2 mutations have been summarized. (Review)

  5. These results of this study provide evidence that the mutation of COL4A2 is associated with lacunar ischemic stroke and deep intracerebral hemorrhage.

  6. COL4A2 expression is significantly upregulated in human masticatory mucosa during wound healing

  7. These results indicate that the CHD (show CHDH Proteins)-related genetic variant at the COL4A2 locus affects COL4A2/COL4A1 (show COL4A1 Proteins) expression, smooth muscle cells survival, and atherosclerotic plaque stability, providing a mechanistic explanation for the association between the genetic variant and CHD (show CHDH Proteins) risk.

  8. Expression of miR (show MLXIP Proteins)-26a and miR (show MLXIP Proteins)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7 (show ADAMTS7 Proteins), ATP1B1 (show ATP1B1 Proteins), COL4A2, CPEB3 (show CPEB3 Proteins), CDK6 (show CDK6 Proteins), DNMT3a (show DNMT3A Proteins) and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.

  9. identified a novel COL4A2 (c.2399G>A, p.G800E, CCDS41907.1) mutation in an autosomal dominant family with porencephaly and ocular abnormalities

  10. No significant change in canstatin levels was observed between normotensive and pre-eclampsia patients.

Mouse (Murine) Collagen, Type IV, alpha 2 (COL4a2) interaction partners

  1. Mutations in murine Col4a1 (show COL4A1 Proteins) and Col4a2 genes affected the balance between lung epithelial progenitors and differentiated cells. Mutations in Col4a1 (show COL4A1 Proteins) derived from the vascular component were sufficient to cause defects in vascular development and the blood-gas barrier. Col4a1 (show COL4A1 Proteins) and Col4a2 mutants displayed disrupted myofibroblast proliferation, differentiation and migration.

  2. COL4A1 (show COL4A1 Proteins) and COL4A2 mutations are pleiotropic and cause a wide spectrum of disorders, including ocular dysgenesis, brain malformations and myopathy, of variable severity in both mice and humans.

  3. WT1 (show WT1 Proteins) maintains testicular cord integrity by additively regulating the expression of basal lamina components Col4a1 (show COL4A1 Proteins) and Col4a2 with SOX9 (show SOX9 Proteins).

  4. Data suggest that podocyte von Hippel-Lindau protein (show VHLL Proteins) is required for normal maintenance of podocytes, basment membrane collagen {alpha}1{alpha}2{alpha}1(IV) deposition and ultrastructure, neuroglobin (show NGB Proteins) experssion and glomerular barrier properties.

  5. In murine embryos, collagen IV (show COL4 Proteins) subunits alpha1(IV), alpha2(IV), alpha5(IV) and alpha6(IV) were detected in the basement membrane surrounding the lens vesicle, and they persisted in the capsule until adulthood.

  6. The genetic, molecular, and phenotypic characterization of nine Col4a1 (show COL4A1 Proteins) and three Col4a2 missense mutations recovered in random mutagenesis experiments in the mouse, are presented.

  7. Foxc2 (show FOXC2 Proteins) plays an important role in the development of the mesenchyme through the regulation of MyoD (show MYOD1 Proteins) gene expression but does not regulate Collagen type IV alpha 1 (Col4a1 (show COL4A1 Proteins)) or Col4a2

  8. These results indicate that SOX9 (show SOX9 Proteins) is essential for Col4a2 expression in mesangial cells and might be involved in the accumulation of alpha2(IV) collagen in experimental nephritis.

Cow (Bovine) Collagen, Type IV, alpha 2 (COL4a2) interaction partners

  1. Results describe the molecular mechanism underlying chain selection in the assembly of collagen IV (show COL4 Proteins), and the kinetics of interaction and assembly of the alpha1(IV) and alpha2(IV) NC1 domains.

COL4a2 Protein Profile

Protein Summary

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Gene names and symbols associated with COL4a2

  • collagen, type IV, alpha 2 L homeolog (col4a2.L)
  • collagen type IV alpha 2 chain (COL4A2)
  • collagen, type IV, alpha 2 (col4a2)
  • collagen, type IV, alpha 2 (Col4a2)
  • collagen type IV alpha 2 chain (Col4a2)
  • Col4a-2 protein
  • col4a2-a protein
  • ICH protein
  • POREN2 protein
  • zCanstatin protein

Protein level used designations for COL4a2

collagen, type IV, alpha 2 , collagen alpha2(IV) , collagen type IV alpha 2 chain , alpha 2 type IV collagen , type IV collagen alpha 2 chain , collagen alpha-2(IV) chain-like , canstatin , collagen alpha-2(IV) chain , procollagen, type IV, alpha 2 , alpha-2 collagen type IV

GENE ID SPECIES
373763 Xenopus laevis
403843 Canis lupus familiaris
418752 Gallus gallus
452661 Pan troglodytes
553355 Danio rerio
100153454 Sus scrofa
100429807 Macaca mulatta
100486079 Xenopus (Silurana) tropicalis
1284 Homo sapiens
12827 Mus musculus
306628 Rattus norvegicus
508632 Bos taurus
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