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CCBE1 encodes a protein containing an emilin domain and two collagen stretches. Additionally we are shipping CCBE1 Antibodies (47) and CCBE1 Kits (5) and many more products for this protein.
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the present results demonstrated that CCBE1 expression was downregulated in lung cancer, particularly in the presence of LNM.
these data indicated that CCBE1 may be served as a new predictor of prognosis in post-operative gastrointestinal stromal tumor patients and may play an important role in stimulating tumor progression
We identify CCBE1 as a direct target of miR-330-3p, and show that knockdown of CCBE1 results in a greater invasive capacity. Accordingly, in breast cancer patients CCBE1 is frequently downregulated, and its loss is associated with reduced distant relapse-free and overall survival.
characterization of Hennekam Syndrome phenotypes in two Turkish siblings with protein mutation
Collagen domains of CCBE1 are crucial for the activation of VEGFC in vitro and in vivo. The EGF domains of CCBE1 are dispensable for regulation of VEGFC processing in vitro, however, they are necessary for full lymphangiogenic activity of CCBE1 in vivo.
CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.
Both siblings harbored a homozygous mutation in CCBE1.
The study has shown that CCBE1 mutations are not a major contributor to non-immune hydrops fetalis.
Human CCBE1 strongly enhances vascular endothelial growth factor-C-mediated lymphangiogenesis in a corneal micropocket assay
Loss of CCBE1 expression may promote ovarian carcinogenesis by enhancing migration & cell survival. CCBE1 is a new candidate tumour suppressor in ovarian cancer.
Homozygous cysteine to serine change and SNPS in CCBE1 were identified patients.
Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans
CCBE1 is essential for coronary vessel formation, independent of their embryonic origin, and is also necessary for peritruncal vessel growth and proper CA stem patterning.
Ccbe1 has an essential role in lymphangiogenesis [review]
The secreted lymphangiogenic protein CCBE1 is essential for fetal but not postnatal erythropoiesis.
Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development
Phenotypic analysis of murine Ccbe1 mutant embryos show a complete lack of definitive lymphatic structures, even though lymphatic endothelial cells are specified within the cardinal vein
In the embryo, phenotypes driven by increased Vegfc are suppressed in the absence of Ccbe1, and Vegfc-driven sprouting is enhanced by local Ccbe1 overexpression. Moreover, Vegfc- and Vegfr3-dependent Erk signaling is impaired in the absence of Ccbe1.
This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans.
collagen and calcium-binding EGF domain-containing protein 1
, full of fluid protein homolog
, collagen and calcium binding EGF domains 1
, full of fluid protein
, LOW QUALITY PROTEIN: collagen and calcium-binding EGF domain-containing protein 1