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Might be involved in complement regulation. Additionally we are shipping Complement Factor H-Related 2 Antibodies (23) and Complement Factor H-Related 2 Kits (2) and many more products for this protein.
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Next-generation sequencing of the CFH (show CFH Proteins) region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH (show CFH Proteins)-related genes in the retina or RPE (show RPE Proteins)/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR2]
Studies indicate that complement factor H (show CFH Proteins)-related proteins (FHR1 (show CFHR1 Proteins)-5) may enhance complement activation, with important implications for the role of these proteins in disease.
Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH (show CFH Proteins)/CFHR1 (show CFHR1 Proteins)-3 and complement factor H (show CFH Proteins) 479.
Thus CFHR2 likely acts in concert with factor H (show CFH Proteins), as CFHR2 inhibits convertases while simultaneously allowing factor H (show CFH Proteins) assisted degradation by factor I.
A hybrid CFHR2-CFHR5 (show CFHR5 Proteins) plasma protein, arising from a chromosomal deletion mutation stabilizes the C3 convertase and reduces factor H (show CFH Proteins)-mediated convertase decay.
Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.
, H factor (complement)-like 3
, complement factor H-related protein 2
, factor H-related gene 2
, h factor-like 3
, h factor-like protein 2