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CBFA2T2 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression.
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in human colorectal cancer (CRC (show CALR Antibodies)) samples MTGR1 was downregulated at both the transcript and protein level. Overall data indicates that MTGR1 has a context-dependent effect on intestinal tumorigenesis.
CBFA2T2 forms a biochemical complex with PRDM14, a germline-specific transcription factor; mechanistically, CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 and OCT4 are stabilized on chromatin
The MTGR1 gene depends on a GC-box-rich sequence for transcriptional regulation and possible ubiquitous expression.
report characterization of two chimeric transcripts identified in AML translocation cases involving CBFA2T2 and C20orf112
ETO (show RUNX1T1 Antibodies) family member-mediated oligomerization and repression can be distinct events and that interaction between ETO (show RUNX1T1 Antibodies) family members and hSIN3B or N-CoR (show NCOR1 Antibodies) may not necessarily strengthen transcriptional repression.
These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth.
Collectively, our findings indicate that CBFA2T2 is required for BMP-2 (show BMP2 Antibodies)-induced osteogenic differentiation of MSCs through inhibition of EHMT1 (show EHMT1 Antibodies)-mediated histone methylation at Runx2 (show RUNX2 Antibodies) promoter.
This repressive function is mediated through an ETO (show RUNX1T1 Antibodies)-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 (show PRDM14 Antibodies) and co-occupies its genomic targets in mouse embryonic stem cells.
Cbfa2t2(-/-) mice display severe defects in primordial germ cell maturation and epigenetic reprogramming
MTGR1 is required for tumorigenesis in the murine AOM (show COL2A1 Antibodies)/DSS (show PMP22 Antibodies) colitis-associated carcinoma model.
Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.
Mtgr1 has an important role in crypt survival and regeneration after colonic epithelial ulceration.
c-Myc (show MYC Antibodies), a transcriptional target of the Wnt (show WNT2 Antibodies) pathway, was overexpressed in the small intestines of mice lacking Mtgr1, thus linking inactivation of Mtgr1 to the activation of a potent oncogene (show RAB1A Antibodies)
Eto2 (show CBFA2T3 Antibodies) and Mtgr1 as authentic interaction partners of Tal1 (show TAL1 Antibodies) and suggest they act as heteromeric corepressors of this bHLH transcription factor (show MSGN1 Antibodies) during erythroid differentiation.
In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
ETO homolog on chromosome 20
, ETO homologous on chromosome 20
, MTG8-like protein
, MTG8-related protein 1
, myeloid translocation gene-related protein 1
, myeloid translocation-related protein 1
, protein CBFA2T2
, CBFA2T2 identified gene homolog
, core-binding factor runt domain alpha subunit 2 translocated to 2 homolog
, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog