anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Antibodies

In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities.

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Application DB, ICC, FACS, WB
Order details Cat. No. ABIN930909
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100 μg
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100 μg
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Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Antigen Profile

Protein Summary

In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Gene names and symbols associated with CBFA2T2

  • CBFA2/RUNX1 translocation partner 2 (Cbfa2t2) antibody
  • CBFA2/RUNX1 translocation partner 2 (CBFA2T2) antibody
  • core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) (Cbfa2t2) antibody
  • CBFA2/RUNX1 translocation partner 2 L homeolog (cbfa2t2.L) antibody
  • A430091M07 antibody
  • C330013D05Rik antibody
  • cbfa2t2-a antibody
  • Cbfa2t2h antibody
  • EHT antibody
  • MTGR1 antibody
  • p85 antibody
  • XETOR antibody
  • ZMYND3 antibody

Protein level used designations for CBFA2T2

translocated to, 2 , myeloid translocation gene-related protein 1 , protein CBFA2T2 , CBFA2T2 identified gene homolog , MTG8-like protein , MTG8-related protein 1 , core-binding factor runt domain alpha subunit 2 translocated to 2 homolog , core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog , ETO homolog on chromosome 20 , ETO homologous on chromosome 20 , myeloid translocation-related protein 1 , a subunit 2; translocated to, 2 , expressed during neurogenesis

GENE ID SPECIES
296293 Rattus norvegicus
419155 Gallus gallus
12396 Mus musculus
9139 Homo sapiens
379213 Xenopus laevis