anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Antibodies

In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. Additionally we are shipping Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBFA2T2 296293  
CBFA2T2 12396 O70374
CBFA2T2 9139 O43439
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Top anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Antibodies at antibodies-online.com

Showing 10 out of 90 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CBFA2T2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Thymus 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CBFA2T2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate CBFA2T2 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells WB Suggested Anti-CBFA2T2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: HepG2 cell lysate  CBFA2T2 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Cbfa2t2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Mouse Brain 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, WB WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using CBFA2T2, antibody at 1:200 dilution. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, WB   0.4 mL 4 to 8 Days
$522.50
Details
Hamster Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB 100 μg 11 to 14 Days
$551.83
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Western Blot analysis of CBFA2T2 expression in transfected 293T cell line by CBFA2T2 monoclonal antibody (M15), clone 2C10.Lane 1: CBFA2T2 transfected lysate(63.9 KDa).Lane 2: Non-transfected lysate. Immunoperoxidase of monoclonal antibody to CBFA2T2 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml] 100 μg 11 to 12 Days
$440.00
Details

Top referenced anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Antibodies

  1. Mouse (Murine) Monoclonal CBFA2T2 Primary Antibody for IP, WB - ABIN533439 : Meier, Krpic, Rodriguez, Strouboulis, Monti, Krijgsveld, Gering, Patient, Hostert, Grosveld: Novel binding partners of Ldb1 are required for haematopoietic development. in Development (Cambridge, England) 2006 (PubMed)

More Antibodies against Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Interaction Partners

Mouse (Murine) Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) interaction partners

  1. Collectively, our findings indicate that CBFA2T2 is required for BMP-2-induced osteogenic differentiation of MSCs through inhibition of EHMT1-mediated histone methylation at Runx2 promoter.

  2. This repressive function is mediated through an ETO-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 and co-occupies its genomic targets in mouse embryonic stem cells.

  3. Cbfa2t2(-/-) mice display severe defects in primordial germ cell maturation and epigenetic reprogramming

  4. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.

  5. Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.

  6. Mtgr1 has an important role in crypt survival and regeneration after colonic epithelial ulceration.

  7. c-Myc, a transcriptional target of the Wnt pathway, was overexpressed in the small intestines of mice lacking Mtgr1, thus linking inactivation of Mtgr1 to the activation of a potent oncogene

  8. Eto2 and Mtgr1 as authentic interaction partners of Tal1 and suggest they act as heteromeric corepressors of this bHLH transcription factor during erythroid differentiation.

Human Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) interaction partners

  1. in human colorectal cancer (CRC) samples MTGR1 was downregulated at both the transcript and protein level. Overall data indicates that MTGR1 has a context-dependent effect on intestinal tumorigenesis.

  2. CBFA2T2 forms a biochemical complex with PRDM14, a germline-specific transcription factor; mechanistically, CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 and OCT4 are stabilized on chromatin

  3. The MTGR1 gene depends on a GC-box-rich sequence for transcriptional regulation and possible ubiquitous expression.

  4. report characterization of two chimeric transcripts identified in AML translocation cases involving CBFA2T2 and C20orf112

  5. ETO family member-mediated oligomerization and repression can be distinct events and that interaction between ETO family members and hSIN3B or N-CoR may not necessarily strengthen transcriptional repression.

  6. These results reveal novel contributions of MTGR1 and GFI1 to the regulation of neurite outgrowth and identify novel repressors of integrin-dependent neurite outgrowth.

Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Antigen Profile

Protein Summary

In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Gene names and symbols associated with CBFA2T2

  • CBFA2/RUNX1 translocation partner 2 (Cbfa2t2) antibody
  • CBFA2/RUNX1 translocation partner 2 (CBFA2T2) antibody
  • core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) (Cbfa2t2) antibody
  • CBFA2/RUNX1 translocation partner 2 L homeolog (cbfa2t2.L) antibody
  • A430091M07 antibody
  • C330013D05Rik antibody
  • cbfa2t2-a antibody
  • Cbfa2t2h antibody
  • EHT antibody
  • MTGR1 antibody
  • p85 antibody
  • XETOR antibody
  • ZMYND3 antibody

Protein level used designations for CBFA2T2

translocated to, 2 , myeloid translocation gene-related protein 1 , protein CBFA2T2 , CBFA2T2 identified gene homolog , MTG8-like protein , MTG8-related protein 1 , core-binding factor runt domain alpha subunit 2 translocated to 2 homolog , core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog , ETO homolog on chromosome 20 , ETO homologous on chromosome 20 , myeloid translocation-related protein 1 , a subunit 2; translocated to, 2 , expressed during neurogenesis

GENE ID SPECIES
296293 Rattus norvegicus
419155 Gallus gallus
12396 Mus musculus
9139 Homo sapiens
379213 Xenopus laevis
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