anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Antibodies

CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Additionally we are shipping Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBFA2T3 12398 O54972
CBFA2T3 863 O75081
CBFA2T3 361431  
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Top anti-Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Antibodies at antibodies-online.com

Showing 10 out of 30 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CBFA2T3 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Jurkat cell lysate CBFA2T3 is supported by BioGPS gene expression data to be expressed in Jurkat Host:  Rabbit  Target Name:  CBFA2T3  Sample Tissue:  Human Fetal Lung  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CBFA2T3 Antibody Titration:  2.5ug/ml  ELISA Titer:  1:312500  Positive Control:  Jurkat cell lysate CBFA2T3 is supported by BioGPS gene expression data to be expressed in Jurkat WB Suggested Anti-CBFA2T3  Antibody Titration: 2.5 µg/mL ELISA Titer: 1:.12500  Positive Control: Jurkat cell lysate  CBFA2T3 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MTG16 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Guinea Pig Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p) 100 μL Log in to see 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 2 to 3 Days
$446.88
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see Available
$363.46
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using CBFA2T3 antibody. 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Mouse Un-conjugated IHC (p), WB Western Blot analysis of CBFA2T3 expression in transfected 293T cell line by CBFA2T3 MaxPab polyclonal antibody.Lane 1: CBFA2T3 transfected lysate(67.65 KDa).Lane 2: Non-transfected lysate. Immunoperoxidase of purified MaxPab antibody to CBFA2T3 on formalin-fixed paraffin-embedded human esophagus. [antibody concentration 3 ug/ml] 50 μL Log in to see 11 to 12 Days
$364.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 2 to 3 Days
$446.88
Details

More Antibodies against Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Interaction Partners

Mouse (Murine) Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) interaction partners

  1. Study reveals a complex pattern of gene regulation by SCL, ETO2 and RYBP. Genome-wide analyses shows locus-specific binding of ETO2 and RYBP on SCL's 778 activated and repressed genes.

  2. gene deficient mice have decreased levels of systemic monocytes and infarct-associated macrophages and display compromised tissue healing and post-MI heart failure

  3. MTG16 loss promotes radioresistance and impacts intestinal stem cell function, possibly due to shifting cellular response away from DNA damage-induced apoptosis and towards DNA repair after injury.

  4. Mtg16 promotes plasmacytoid dendritic cell differentiation and restricts classical dendritic cell development in part by repressing Id2.

  5. MTG16 is critical for colonocyte survival and regeneration in response to intestinal injury and provide evidence that this transcriptional corepressor regulates inflammatory recruitment in response to injury.

  6. Mtg16 integrates the activities of signaling pathways and nuclear factors in the establishment of T-cell fate specification.

  7. Data suggest that MTG16 interfaces with critical components of the Notch transcription complex to affect Notch-dependent lineage allocation in hematopoiesis.

  8. association with T-cell acute lymphocytic leukemia 1, ETO-2 represses gene expression in the early stages of erythroid differentiation

  9. The dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation.

  10. MTG8/ETO and Mtg16 (also known as ETO2) associated with TCF4

  11. These data suggest that ETO2 directly represses inappropriate early expression of a subset of terminally expressed megakaryocyte genes by binding to GATA1 and SCL.

  12. the transcriptional corepressor Mtg16 (myeloid translocation gene on chromosome 16), which is targeted by t(16;21) in acute myeloid leukemia, is required for hematopoietic progenitor cell fate decisions and for early progenitor cell proliferation.

  13. Eto2 and Mtgr1 as authentic interaction partners of Tal1 and suggest they act as heteromeric corepressors of this bHLH transcription factor during erythroid differentiation.

Human Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) interaction partners

  1. The here presented transcriptomic subgroup-based approach unified the gene expression profiles of RUNX1-CBFA2T3 and RUNX1-RUNX1T1 acute myeloid leukemia.

  2. Analysis of chromatin immunoprecipitation sequencing data sets for MTGR1 and MTG16 targets indicated that MTGR1 can regulate Wnt and Notch signaling.

  3. CBFA2T3 expression is regulated by Med19 in breast cancer cells.

  4. specific interference with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia.

  5. Clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene are poor due to resistance to chemotherapies and SCT. New treatment strategies are necessary.

  6. ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation.

  7. MTG16 co-repressor promotes degradation of HIF1alpha in lymphoblasts.

  8. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A.

  9. Findings are unprecedented and indicate that the DHH-RHEBL1 fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2-positive childhood AML.

  10. Expression of MTG16 reduced glycolytic metabolism while mitochondrial respiration and formation of reactive oxygen species increased.

  11. presence of MTG16 in this complex, and its contributions to transcriptional repression both required Kaiso binding to its binding site on DNA, establishing MTG16-Kaiso binding as functionally relevant in Kaiso-dependent transcriptional repression

  12. Data indicate taht ETO2/CBFA2T3 regulates GATA-1 target genes critical for erythroid differentiation, and the decrease of ETO2 levels during erythroid differentiation would contribute to the activation of these targets.

  13. Identification of a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3-GLIS2 fusion protein.

  14. An evolutionary conserved GATA binding site is critical in transcriptional regulation of the MTG16 promoter.

  15. Our data indicate that the CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma.

  16. Alternative NLI complexes mediate gamma-globin transcription or silencing through long-range locus control region interactions involving an intergenic site of noncoding RNA transcription and that ETO2 is critical to this process.

  17. Study provides the first evidence that MTG16b is a dual AKAP capable of binding plexins.

  18. Data show that ZNF651 is a ZNF652 paralogue that shares a common DNA binding sequence with ZNF652 and represses target gene expression through the formation of a CBFA2T3-ZNF651 corepressor complex.

  19. In the first pediatric leukemia case in whom AML1-MTG16 was identified, the breakpoint of MTG16 was determined, and suggested as a possible characteristic of secondary leukemia.

  20. CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3.

Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Antigen Profile

Protein Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16\;21)(q24\;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

Gene names and symbols associated with CBFA2T3

  • core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3) antibody
  • CBFA2/RUNX1 translocation partner 3 (CBFA2T3) antibody
  • CBFA2/RUNX1 translocation partner 3 (Cbfa2t3) antibody
  • A630044F12Rik antibody
  • AI465270 antibody
  • AW229127 antibody
  • Cbfa2t3h antibody
  • ETO-2 antibody
  • ETO2 antibody
  • MTG16 antibody
  • MTG16a antibody
  • MTG16b antibody
  • MTGR2 antibody
  • ZMYND4 antibody

Protein level used designations for CBFA2T3

ETO/MTG8-related protein ETO-2 , MTG8-related protein 2 , core-binding factor, runt domain, alpha subunit 2; translocated to, 3 homolog; CBFA2T3 identified gene homolog , eight twenty one protein 2 , myeloid translocation gene-related protein 2 , protein CBFA2T3 , protein ETO-2 , MTG8-related gene 2 , myeloid translocation gene 8 and 16b , myeloid translocation gene on chromosome 16 protein , zinc finger MYND domain-containing protein 4 , translocated to, 3

GENE ID SPECIES
12398 Mus musculus
415846 Gallus gallus
863 Homo sapiens
361431 Rattus norvegicus
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