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CBFA2T2 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression.
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Analysis of chromatin immunoprecipitation sequencing data sets for MTGR1 and MTG16 (show CBFA2T3 Antibodies) targets indicated that MTGR1 can regulate Wnt (show WNT2 Antibodies) and Notch (show NOTCH1 Antibodies) signaling.
CBFA2T3 (show CBFA2T3 Antibodies) expression is regulated by Med19 (show MED19 Antibodies) in breast cancer cells.
specific interference with ETO2 (show CBFA2T3 Antibodies)-GLIS2 (show GLIS2 Antibodies) oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia.
Clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene are poor due to resistance to chemotherapies and SCT. New treatment strategies are necessary.
CBFA2T2 forms a biochemical complex with PRDM14, a germline-specific transcription factor; mechanistically, CBFA2T2 oligomerizes to form a scaffold upon which PRDM14 and OCT4 are stabilized on chromatin
ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation.
MTG16 (show CBFA2T3 Antibodies) co-repressor promotes degradation of HIF1alpha (show HIF1A Antibodies) in lymphoblasts.
study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP (show CREBBP Antibodies), CBFA2T3 (show CBFA2T3 Antibodies), AMOTL1 (show AMOTL1 Antibodies), FAT4 (show FAT4 Antibodies), FBXO11 (show FBXO11 Antibodies), PLA2G4D, TRRAP (show TRRAP Antibodies) and USH2A (show USH2A Antibodies).
Findings are unprecedented and indicate that the DHH (show DHH Antibodies)-RHEBL1 (show RHEBL1 Antibodies) fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3 (show CBFA2T3 Antibodies)-GLIS2 (show GLIS2 Antibodies)-positive childhood AML (show RUNX1 Antibodies).
Expression of MTG16 (show CBFA2T3 Antibodies) reduced glycolytic metabolism while mitochondrial respiration and formation of reactive oxygen species increased.
This repressive function is mediated through an ETO (show RUNX1T1 Antibodies)-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 (show PRDM14 Antibodies) and co-occupies its genomic targets in mouse embryonic stem cells.
Cbfa2t2(-/-) mice display severe defects in primordial germ cell maturation and epigenetic reprogramming
MTGR1 is required for tumorigenesis in the murine AOM (show COL2A1 Antibodies)/DSS (show PMP22 Antibodies) colitis-associated carcinoma model.
Loss of Mtgr1 impairs the maturation of secretory cells in the small intestine.
Mtgr1 has an important role in crypt survival and regeneration after colonic epithelial ulceration.
c-Myc (show MYC Antibodies), a transcriptional target of the Wnt (show WNT2 Antibodies) pathway, was overexpressed in the small intestines of mice lacking Mtgr1, thus linking inactivation of Mtgr1 to the activation of a potent oncogene (show RAB1A Antibodies)
Eto2 (show CBFA2T3 Antibodies) and Mtgr1 as authentic interaction partners of Tal1 (show TAL1 Antibodies) and suggest they act as heteromeric corepressors of this bHLH transcription factor (show MSGN1 Antibodies) during erythroid differentiation.
In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
ETO homolog on chromosome 20
, ETO homologous on chromosome 20
, MTG8-like protein
, MTG8-related protein 1
, myeloid translocation gene-related protein 1
, myeloid translocation-related protein 1
, protein CBFA2T2
, CBFA2T2 identified gene homolog
, core-binding factor runt domain alpha subunit 2 translocated to 2 homolog
, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog