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Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. Additionally we are shipping Creatine Kinase, Mitochondrial 1B Kits (36) and Creatine Kinase, Mitochondrial 1B Proteins (3) and many more products for this protein.
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The highly conserved residue E227 acts as the catalytic base to accept the guanidinium proton transferred from creatine in UMTCK.
Mitochondrial creatine kinase CKMT1 is necessary for survival of EVI1-expressing cells in subjects with EVI1-positive AML.
LRRK2 can interact directly with uMtCK to block its entry into mitochondria and its subsequent processing.
CKMT1 is a key regulator of the permeability transition pore through a complex that is distinct from the classical permeability transition pore.
mitochondrial creatine kinase expression in hepatocellular carcinoma may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator
The results indicated that uMtCK expression is associated with a poor prognosis in breast cancer and might serve as a tumor marker.
Significantly greater creatine kinase carbonylation is associated with chronic obstructive pulmonary disease
Because creatine kinase temporally buffers ATP, these observations support the hypothesis that a deficit in myofibrillar energy delivery contributes to chronic heart failure pathophysiology in human left ventricular hypertrophy.
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase\\\\; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
creatine kinase U-type, mitochondrial
, acidic-type mitochondrial creatine kinase
, creatine kinase, mitochondrial 1 (ubiquitous)
, ubiquitous mitochondrial creatine kinase
, creatine kinase, ubiquitous mitochondrial