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CNNM2 encodes a member of the ancient conserved domain containing protein family. Additionally we are shipping Cyclin M2 Antibodies (52) and many more products for this protein.
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CNNM2 single nucleotide polymorphisms association with the risk of hypertension in Chinese Han population.
In this large-scale, Han Chinese population-based genetic association study for genetic susceptibility to schizophrenia of a three-gene cluster region, AS3MT-CNNM2-NT5C2, two SNPs with independent effects, rs11191419 and rs11191514, were identified. Rs11191419 is located on the 5' (potential promoter) region of AS3MT, while rs11191514 is located in one of the introns of CNNM2.
this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus
Sensitivity of CNNM2 expression to extracellular Mg(2+) depletion depends on cell type.
meta-analysis of two Caucasian cohorts did not show an association between five aneurysm associated loci and sporadic brain Arteriovenous malformations.
The T568I mutation causes the magnesium transporter, CNNM2, to become 'locked' in its flat form.
Cells expressing mutated CNNM2 proteins did not show increased Mg(2+) uptake.
This CNNM2 risk variant rs7914558 may have an impact on neural systems relevant to social cognition.
Our findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the gray matter volumetric vulnerability of the orbital regions in the inferior frontal gyri.
crystals of CNNM2 belonged to space groups P2(1)2(1)2 and I222 (or I2(1)2(1)2(1)) and diffracted X-rays to 2.0 and 3.6 A resolution, respectively, using synchrotron radiation
analysis of structure of CNNM2 and its post-translational modifications
ACDP2 splice-variant 1 is a functional Mg2+-transporting entity per se.
The CNNM2 locus is associated with serum Mg(2+) concentrations.
we generated kidney-specific Cnnm2- deficient mice and clearly demonstrated that the CNNM2 function in the kidney is important in maintaining not only magnesium homeostasis but also blood pressure.
data shed new light on the structural basis underlying the interaction between PRL phosphatases and CNNM transporters and provides a hypothesis about the molecular mechanism by which PRL-1, upon binding to CNNM2, might increase the intracellular concentration of Mg(2+) thereby contributing to tumor progression and metastasis.
Thus, sperm motility and Ca(2+) response were more severely affected in sperm from Cnnm2(+/Delta); Cnnm4(Delta/Delta) mice than in those from Cnnm4(Delta/Delta) mice, implicating CNNM2 in regulating these processes.
ACDP2 may provide a regulated transporter for Mg2+ and other divalent cations in epithelial ce
This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, metal transporter CNNM4
, ancient conserved domain-containing protein 4
, ancient conserved domain-containing protein 2
, metal transporter CNNM2
, ancient conserved domain protein 2
, cyclin-like protein 2