Cyclin M4 Proteins (CNNM4)

CNNM4 encodes a member of the ancient conserved domain containing protein family. Additionally we are shipping CNNM4 Antibodies (46) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CNNM4 26504 Q6P4Q7
CNNM4 94220 Q69ZF7
Rat CNNM4 CNNM4 363216 P0C588
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Top CNNM4 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60 to 65 Days
$10,888.92
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$7,639.51
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

CNNM4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Cyclin M4 (CNNM4) Interaction Partners

Human Cyclin M4 (CNNM4) interaction partners

  1. Results identified linkage at chromosome 2p14-2q14 and found a homozygous mutation in the CNNM4 gene (p.R605X) causing Jalili syndrome. The truncated CNNM4 protein starting at R605 significantly increased the rate of apoptosis, and significantly increased the interaction between CNNM4 and IQCB1 (show IQCB1 Proteins). This mutation may cause Jalili syndrome by a nonsense-mediated decay mechanism, affecting the function of IQCB1 (show IQCB1 Proteins) and apoptosis.

  2. Mutational analysis showed in all three brothers a novel likely pathogenic homozygous missense substitution in exon 1 (c.1076T>C, p.(Leu359Pro)) of CNNM4. Both parents were carriers for the variant.

  3. We describe three siblings with clinical features of Jalili syndrome with a homozygous missense mutation in exon 4 of CNNM4, c.1781A>G (p.N594S).

  4. These results suggest a new role of CNNM4 in sperm Ca(2 (show CA2 Proteins)+) homeostasis.

  5. We identified a novel homozygous deleterious mutation in CNNM4 gene which causes Jalili syndrome.

  6. used Sanger sequencing to analyze a large consanguineous family with three siblings affected with Jalili syndrome, suspected clinically after dental and ophthalmological examination. These patients are carrying a novel homozygous mutation in the splice site acceptor of intron 3 (c.1682-1G > C) in the CNNM4 gene

  7. these results indicate that CNNM4-dependent Mg(2 (show MUC7 Proteins)+) efflux suppresses tumor progression by regulating energy metabolism.

  8. The c.1312 dupC mutation of CNNM4 leads to a premature termination of amelogenesis resulting in thin, incompletely mineralized enamel, whereas in dentin, only mineralization is disturbed.

  9. CNNM4 is sorted to the basolateral membrane by the complementary function of AP-1A and AP-1B

  10. Data indicate that a mutation in the cystathionine-beta-synthase (CBS (show CBS Proteins)) domains of ancient conserved domain protein 4/cyclin M4 CNNM4 completely abrogated their Mg2 (show MUC7 Proteins)+ efflux functions.

Mouse (Murine) Cyclin M4 (CNNM4) interaction partners

  1. These results suggest a new role of CNNM4 in sperm Ca(2 (show CA2 Proteins)+) homeostasis.

  2. these results indicate that CNNM4-dependent Mg(2 (show MCOLN1 Proteins)+) efflux suppresses tumor progression by regulating energy metabolism.

CNNM4 Protein Profile

Protein Summary

This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta.

Gene names and symbols associated with Cyclin M4 Proteins (CNNM4)

  • cyclin and CBS domain divalent metal cation transport mediator 4 (CNNM4)
  • cyclin M4 (CpipJ_CPIJ006743)
  • cyclin and CBS domain divalent metal cation transport mediator 4 (cnnm4)
  • cyclin M4 (CNNM4)
  • cyclin M4 (Cnnm4)
  • cyclin and CBS domain divalent metal cation transport mediator 4 (Cnnm4)
  • 5430430O18Rik protein
  • Acdp4 protein
  • DKFZp468E0110 protein

Protein level used designations for Cyclin M4 Proteins (CNNM4)

cyclin M4 , metal transporter CNNM4 , metal transporter CNNM4-like , ancient conserved domain protein 4 , ancient conserved domain-containing protein 4 , cyclin-M4 , mACDP4

GENE ID SPECIES
470441 Pan troglodytes
481346 Canis lupus familiaris
522382 Bos taurus
6039516 Culex quinquefasciatus
100145459 Xenopus (Silurana) tropicalis
100171845 Pongo abelii
100350726 Oryctolagus cuniculus
100385505 Callithrix jacchus
100474003 Ailuropoda melanoleuca
100030418 Monodelphis domestica
100062145 Equus caballus
100539096 Meleagris gallopavo
100598219 Nomascus leucogenys
26504 Homo sapiens
94220 Mus musculus
363216 Rattus norvegicus
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