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The protein encoded by CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. Additionally we are shipping CDK10 Antibodies (102) and CDK10 Proteins (6) and many more products for this protein.
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The findings of this study indicate that CDK10 plays a role in the pathogenesis in colorectal cancer and may be a potential therapeutic target for treatment.
These findings underscore the importance of CDK10 for the regulation of ciliogenesis. CDK10 defect is likely associated with a new form of ciliopathy phenotype; additional patients may further validate this association
CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays.
CDK10/CycM is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA (show RHOA ELISA Kits) signaling.
Down-regulated CDK10 expression frequently occurs in breast cancers and correlates with disease progression and poor survival
Results found that CDK10 mRNA expression was up-regulated in advanced breast neoplasm and positively correlated with C1orf63, which was consistent with the relationship of protein expression between C1orf63 and CDK10.
Data suggest that reactivation of CDK10 might be utilized as a novel epigenetic strategy for the treatment of nasopharyngeal carcinomas (NPC (show NPC1 ELISA Kits)) patients.
CDK10/cyclin M (show CCNL2 ELISA Kits) is a protein kinase (show CDK7 ELISA Kits) that controls ETS2 (show ETS2 ELISA Kits) degradation and is deficient in STAR syndrome.
Data show that peptidyl-prolyl isomerase Pin (show PPI ELISA Kits)1 sil (show PIN1 ELISA Kits)encing in SKBR-3 and MCF7 cells increased the cyclin-dependent kinase 10 (CDK10) expression.
CDK10 plays a crucial role in the growth and survivability of biliary tract cancer.
Data indicate that peptidyl-prolyl isomerase (show PPI ELISA Kits) Pin1 (show PIN1 ELISA Kits)(-/-) mouse embryonic fibroblasts (MEFs) showed higher cyclin-dependent kinase 10 (CDK10) expression than Pin1 (show PIN1 ELISA Kits)(+/+) MEFs.
Data show that murine cdk10 binds Ets2 (show ETS2 ELISA Kits) transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed.
Discusses PISSLRE, the human ortholog of mouse cyclin-dependent kinase 10.
cdk10 has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a (show RAF1 ELISA Kits) expression
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene.
CDC2-related protein kinase
, cell division protein kinase 10
, cyclin-dependent kinase (CDC2-like) 10
, cyclin-dependent kinase related protein
, serine/threonine protein kinase PISSLRE
, serine/threonine-protein kinase PISSLRE
, cyclin dependent kinase 10
, PITSLRE subfamily protein kinase
, protein kinase, CMGC group
, cyclin-dependent kinase 10
, cell division protein kinase 10-like
, hypothetical protein