anti-Cystatin C (CST3) Antibodies

Human Cystatin C (CST3) interaction partners

1. Data suggest that kinetics of degradation/proteolysis versus of aggregation of amyloid beta(1-40) and amyloid beta(1-42) at specific concentrations of amyloid beta, cathepsin B (show CTSB Antibodies), and cystatin C can be modeled and predicted.

2. Serum CysC, at the time of CRRT (Continuous Renal Replacement Therapy cessation), is an independent predictor of the successful weaning from CRRT in critically ill patients with acute kidney injury.

3. The serum levels of cystatin C and urine NGAL (show LCN2 Antibodies), urine OPN (show SPP1 Antibodies) can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population.

4. The average of estimated glomerular filtration rate (eGFRave) based on creatinine (eGFRcre) and eGFR based on cystatin C (eGFRcys) best predicted the exacerbation of renal function in allogeneic hematopoietic cell transplantation (allo-HCT).

5. Studied serum Cystatin C as a biomarker in bladder urothelial neoplasm; results found serum Cystatin C not to be a reliable marker in predicting bladder urothelial tumors tumorigenesis and clinicopathological characteristics.

6. bladder cancer (BCa (show BLNK Antibodies)) patients have lower serum cysC concentration than the control group. Serum cysC may be considered as a potential marker of BCa (show BLNK Antibodies) but not its aggressiveness.

7. Postoperative serum Cystatin C, IL-18 (show IL18 Antibodies) and Uric acid after 24h were significantly associated with acute kidney injury

8. Serum CysC is a strong predictor of AKI and the short-term prognosis of CCU patients.

9. Neutrophil gelatinase-associated lipocalin (show LCN2 Antibodies) concentrations in the urine and serum on the second day of intensive care unit admission could be used to predict the development of acute kidney injury in the following three to seven days in the intensive care unit; however, the cystatin C concentration did not have predictive value

10. Study demonstrated that the binding of CST3 and PSAP (show PSAP Antibodies) decreased the inhibitory effects of CST3 on proteinase in vitro. The co-localization of both proteins was detected in cultured cells and in Bunina body-containing motor neurons from patients with amyotrophic lateral sclerosis, suggesting that they might be involved in the process of Bunina body formation.

Mouse (Murine) Cystatin C (CST3) interaction partners

1. CysC plays an important regulatory role in combating cell death via the autophagic pathway in atherosclerosis.

2. Data (including data from studies in mutant mice) suggest that up-regulation of Cst3, as observed in plasma of mice with type 2 diabetes, down-regulates insulin (show INS Antibodies) signaling and promotes endoplasmic reticulum stress in hepatocytes but not in myotubes.

3. Cystatin C is a potential pathogenic signal triggering neurodegeneration in multiple system atrophy.

4. The neuroprotective activity of CysC against Amyotrophic lateral sclerosis-linked mutant Cu/Zn-superoxide dismutase (SOD1 (show SOD1 Antibodies))-mediated toxicity.

5. an important role for macrophages, DC, and ROS (show ROS1 Antibodies) in diseases associated with the protease inhibitory activity or amyloidogenic properties of cystatin C.

6. APP (show APP Antibodies) expression stimulates NSPC proliferation; this effect is mediated via an increase in cystatin C secretion

7. Cystatin C, a protein targeted to the classical secretory pathway by its signal peptide sequence, is secreted by primary neurons in at least 9 different cystatin C glycoforms associated with exosomes.

8. The lack of cystatin C enhances Collagen-induced arthritis and primarily affects in vivo priming of the immune system

9. Inflammation causes downregulation of cystatin C expression in dendritic cells and reduces serum CstC levels.

10. Data show that the absence of cystatin C reduced epithelial cell apoptosis but increased proliferation in skin.

Pig (Porcine) Cystatin C (CST3) interaction partners

1. CST3 may be required to remodel endometrial and placental tissues for close apposition between maternal and fetal vasculatures and to facilitate transplacental transport of gases, micronutrients (amino acids, glucose), and macromolecules (proteins).

Rabbit Cystatin C (CST3) interaction partners

1. Increased production of cystatin C in osteoarthritis synovium does not alleviate synovitis or cartilage pathology.

Cow (Bovine) Cystatin C (CST3) interaction partners

1. Cystatin C in milk basic protein (MBP (show MBP Antibodies)) is suggested as one of the factors inhibiting bone resorption