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May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity). Additionally we are shipping CRELD2 Proteins (11) and CRELD2 Kits (4) and many more products for this protein.
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intravesicular acidification by V-ATPase regulates the secretion of CRELD2 without relying on the balance of intracellular calcium ions and the expression of endoplasmic reticulum chaperones such as GRP78 and protein disulfide isomerase.
We demonstrate that Armet and Creld2 are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 is a key disease trigger in MED that could be exploited as a potential therapeutic target
results strongly suggest that Creld2 may be directly regulated by BMP9 and ER stress response may play an important role in regulating osteogenic differentiation
CRELD2 can act as a specific regulator of alpha4beta2 nAChR expression
Mapping of CRELD2 by FISH shows that it maps to 22q13 rather than the GenBank reported locus of 22p13.
These results show that the mouse CRELD2 and ALG12 genes are arranged as a unique bidirectional gene pair.
CRELD2 could be a novel mediator in regulating the onset and progression of various ER stress-associated diseases.
May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity).
cysteine-rich with EGF-like domain protein 2
, cysteine-rich with EGF-like domains 2