anti-Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Antibodies

CFTR encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Additionally we are shipping CFTR Kits (35) and CFTR Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CFTR 1080 P13569
CFTR 12638 P26361
CFTR 24255 P34158
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Top anti-CFTR Antibodies at antibodies-online.com

Showing 10 out of 233 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC (p) Formalin fixed paraffin embedded human pancreas stained with CFTR antibody ABIN115197 1 mL Log in to see 6 to 8 Days
$841.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-CFTR antibody, Western blotting WB: Rat Pancreas Tissue Lysate Anti-CFTR antibody, IHC(P) IHC(P): Human Pancreatic Cancer Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Chicken Mouse Un-conjugated BP, FACS, ICC, IF, IHC, IHC (p), IP, Neut, WB Immunocytochemistry/Immunofluorescence: CFTR Antibody (CF3) [ABIN152670] - CFTR staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing CFTR at a dilution of 1:100-1:200 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated. Immunohistochemistry-Paraffin: CFTR Antibody (CF3) [ABIN152670] - Cancer biopsies of deparaffinized Human colon carcinoma tissue. 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of CFTR staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. w Western blot analysis of CFTR expression in SHSY5Y (A), NIH3T3 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using CFTR (Ab-737) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CFTR (Ab-737) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using CFTR Polyclonal Antibody. 100 μL Log in to see 16 Days
$181.73
Details
Human Mouse Un-conjugated IHC (fro), IHC (p) Formalin fixed paraffin embedded human pancreas stained with CFTR antibody ABIN115197 0.5 mL Log in to see 6 to 8 Days
$522.50
Details
Human Rabbit Un-conjugated ICC, IF Figure 1 shows immunolocalization of CFTR in HEK293 cells stably transfected with the CFTR gene. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Rabbit Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 6 Days
$275.00
Details
Human Mouse Un-conjugated IF, IHC (p), IP Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) 250 μL Log in to see 7 to 9 Days
$727.83
Details

CFTR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CFTR Antibodies

  1. Chicken Monoclonal CFTR Primary Antibody for BP, FACS - ABIN152670 : Walker, Watson, Holmes, Edelman, Banting et al.: Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related ... in Journal of cell science 1995 (PubMed)
    Show all 9 Pubmed References

  2. Human Monoclonal CFTR Primary Antibody for IF, IHC (p) - ABIN5575335 : Riordan, Rommens, Kerem, Alon, Rozmahel, Grzelczak, Zielenski, Lok, Plavsic, Chou: Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. in Science (New York, N.Y.) 1989 (PubMed)

More Antibodies against CFTR Interaction Partners

Human Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. Results showed that CFTR was down-regulated in nasopharyngeal carcinoma (NPC (show NPC1 Antibodies)) tissues and cell lines, and that that low expression levels of CFTR are associated with cancer progression and poor survival of NPC (show NPC1 Antibodies) patients. Also, the study demonstrates that CFTR manipulation in NPC (show NPC1 Antibodies) cell lines affects cell migration and invasion, providing mechanistic basis for the role of CFTR in NPC (show NPC1 Antibodies) development.

  2. study's results help fill in knowledge gaps about particular CFTR variants. More than 2,000 different CF mutations have been reported, but according to a widely used database called Clinical and Functional Translation of CFTR (CFTR2), only 10% are categorized as disease-causing

  3. The p.H609R was found cystic fibrosis (show S100A8 Antibodies)-causing mutations in homozygous state in four patients with cystic fibrosis (show S100A8 Antibodies) symptoms.

  4. Sweat chloride and respiratory symptom scores improved with lumacaftor/ivacaftor, though no meaningful benefit was seen in ppFEV1 or body mass index in patients heterozygous for F508del-CFTR.

  5. Authors determined the amino acids inserted at the cystic fibrosis transmembrane conductance regulator (CFTR) W1282X PTC (show F9 Antibodies) (a UGA codon) in the context of its three upstream and downstream CFTR codons during G418-mediated suppression.

  6. CFTR is strongly expressed in sebaceous glands; in the eccrine glands and ducts, CFTR is located on the apical side of the membrane

  7. In patients with Cystic Fibrosis (show S100A8 Antibodies) and G551D mutation Extra-esophageal reflux may lead to respiratory microaspiration and probably cause the deterioration of lung function.

  8. In patients with Cystic Fibrosis (show S100A8 Antibodies) and a G551D CFTR mutation, we demonstrated substantial variability of the sweat chloride concentrations.

  9. Heme-independent activation of the CFTR channel and the Slo1 BKCa (show KCNMA1 Antibodies) channel by carbon monoxide (CO) may represent two different modes of gating regulation of ion channels by CO. In the case of CFTR, Fe3+ is bound to the R-ICL3 interface.15,16 This interfacial Fe3+ site is formed by traditional coordination ligands such as H950 and H954 from ICL3 and C832 and D836 from the R domain. [Review]

  10. Endogenous oestrogen upregulates the expressions and functional activities of CFTR and SLC26A6 (show SLC26A6 Antibodies) in duodenal mucosa.

Xenopus laevis Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. NDPK-A (show NME1 Antibodies) exists in a functional cellular complex with AMPK (show PRKAA2 Antibodies) and CFTR in airway epithelia, and NDPK-A (show NME1 Antibodies) catalytic function is required for the AMPK (show PRKAA2 Antibodies)-dependent regulation of CFTR

  2. Study conclude that when both CFTR and NPT2a are expressed in X. laevis oocytes, CFTR confers to NPT2a a cAMPi-dependent trafficking to the membrane.

  3. wild-type CFTR channel gating cycle is essentially irreversible and tightly coupled to the ATPase (show DNAH8 Antibodies) cycle, and that this coupling is completely destroyed by the NBD2 Walker B mutation D1370N but only partially disrupted by the NBD1 Walker A mutation K464A.

  4. The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that belongs to the superfamily of ATP binding cassette (ABC (show ABCB6 Antibodies)) transporters.

  5. These data suggest that the Xenopus P2Y1 receptor (show P2RY1 Antibodies) can increase both cyclic AMP (show TMPRSS5 Antibodies)/protein kinase A and calcium/protein kinase C (show PKC Antibodies) levels and that the PKC (show PKC Antibodies) pathway is involved in CFTR activation via potentiation of the PKA pathway.

Mouse (Murine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. these results demonstrate that CFTR prevents inflammation and atherogenesis via inhibition of NFkappaB and MAPKs activation

  2. CFTR physically interacts with beta-catenin (show CTNNB1 Antibodies), defect of which leads to premature degradation of beta-catenin (show CTNNB1 Antibodies) and suppressed activation of beta-catenin (show CTNNB1 Antibodies) signaling.

  3. CFTR attaches tumor suppressor PTEN to the membrane and promotes anti Pseudomonas aeruginosa immunity.

  4. Our studies reveal a novel function for CFTR in antiviral immunity and demonstrate that the DeltaF508 mutation in cftr is coupled to an impaired adaptive immune response. This important insight could open up new approaches for patient care and treatment.

  5. a new and more convenient approach, based on in vivo imaging analysis, has been set up to evaluate the inflammatory response in the lung of CFTR-deficient (CF) mice, a murine model of cystic fibrosis (show S100A8 Antibodies).

  6. results reveal that by potentiating adenosine triphosphate-sensitive K+ (KATP) channel, cystic fibrosis transmembrane conductance regulator CFTR acts as a glucose-sensing negative regulator of glucagon (show GCG Antibodies) secretion in alpha cells

  7. This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway.

  8. CFTR is a tumor suppressor gene in murine and human colorectal cancer

  9. Insulin (show INS Antibodies) stimulation of Akt1 (show AKT1 Antibodies) and Akt2 (show AKT2 Antibodies) signaling in Cystic fibrosis (show S100A8 Antibodies) airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR.

  10. Biotinylation and streptavidin pull-down assays confirmed that CAL (show S100A11 Antibodies) dramatically reduces the expression level of total and cell surface Mrp2 (show ABCC2 Antibodies) in Huh-7 cells. Our findings suggest that CAL (show S100A11 Antibodies) interacts with Mrp2 (show ABCC2 Antibodies) and is a negative regulator of Mrp2 (show ABCC2 Antibodies) expression.

Pig (Porcine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium.

  2. Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness.

  3. Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands.

  4. TGF-beta1 (show TGFB1 Antibodies), via TGF-beta1 (show TGFB1 Antibodies) receptor I and p38 MAPK (show MAPK14 Antibodies) signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.

  5. The esophageal submucosal glands (SMG (show SNRPG Antibodies)) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus.

  6. data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis (show S100A8 Antibodies) are likely primary

  7. The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR.

  8. CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation

  9. These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis (show S100A8 Antibodies) pigs, reveal some spared function in the DeltaF508 vs. null piglets.

  10. causal link between CFTR mutations and partial or total vas (show AVP Antibodies) deferens and/or epididymis atresia at birth

Cow (Bovine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I (show DNASE1 Antibodies) hypersensitive sites showed high homology in cow and pig.

Guinea Pig Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. Results demonstrate functional coupling between Cftr and Slc26a6 (show SLC26A6 Antibodies)-like Cl(-)/HCO(3)(-) exchange activity in apical membrane of guinea pig pancreatic interlobular duct.

Zebrafish Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) interaction partners

  1. Molecular dynamics of the cryo-EM CFTR structure

  2. Study presents the structure of zebrafish CFTR in the phosphorylated, ATP-bound conformation, determined by cryoelectron microscopy to 3.4 A resolution. Comparison of the two conformations shows major structural rearrangements leading to channel opening.

  3. Study determined the structure of the zebrafish CFTR by electron cryo-microscopy to 3.7 A resolution; shares 55% sequence identity with human CFTR, and 42 of the 46 cystic-fibrosis (show S100A8 Antibodies)-causing missense mutational sites are identical.

  4. Cftr mutant zebrafish develops pancreatic destruction similar to cystic fibrosis (show S100A8 Antibodies) of the human pancreas.

CFTR Antigen Profile

Protein Summary

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.

Gene names and symbols associated with CFTR

  • cystic fibrosis transmembrane conductance regulator (CFTR) antibody
  • cystic fibrosis transmembrane conductance regulator (cftr-A) antibody
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR) antibody
  • cystic fibrosis transmembrane conductance regulator (Cftr) antibody
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (cftr) antibody
  • abc35 antibody
  • abcc7 antibody
  • AW495489 antibody
  • CF antibody
  • CFTR antibody
  • cftr/mrp antibody
  • dJ760C5.1 antibody
  • mrp7 antibody
  • RGD1561193 antibody
  • si:dkey-270i2.2 antibody
  • tnr-cftr antibody
  • xcftr antibody

Protein level used designations for CFTR

cAMP-dependent chloride channel , channel conductance-controlling ATPase , cystic fibrosis transmembrane conductance regulator , cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) , cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) , ATP-binding cassette sub-family C member 7 , ATP-binding cassette transporter sub-family C member 7 , ATP-binding cassette, subfamily c, member 7 , cystic fibrosis transmembrane conductance regulator homolog , cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7 , CFTR chloride channel , chloride channel , CFTR cAMP-dependent chloride channel protein , Channel conductance-controlling ATPase , abcc7

GENE ID SPECIES
1080 Homo sapiens
373725 Xenopus laevis
780954 Monodelphis domestica
100137161 Nomascus leucogenys
12638 Mus musculus
24255 Rattus norvegicus
100049619 Gallus gallus
492302 Canis lupus familiaris
100071259 Equus caballus
403154 Sus scrofa
281067 Bos taurus
443347 Ovis aries
100009471 Oryctolagus cuniculus
463674 Pan troglodytes
100137035 Pongo abelii
100719898 Cavia porcellus
100381094 Xenopus laevis
100126675 Papio anubis
559080 Danio rerio
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