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CFTR encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Additionally we are shipping CFTR Kits (35) and CFTR Proteins (7) and many more products for this protein.
Showing 10 out of 233 products:
Chicken Monoclonal CFTR Primary Antibody for BP, FACS - ABIN152670
Walker, Watson, Holmes, Edelman, Banting et al.: Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related ... in Journal of cell science 1995
Show all 9 Pubmed References
Human Monoclonal CFTR Primary Antibody for IF, IHC (p) - ABIN5575335
Riordan, Rommens, Kerem, Alon, Rozmahel, Grzelczak, Zielenski, Lok, Plavsic, Chou: Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. in Science (New York, N.Y.) 1989
CFTR insertion in the plasma membrane results in local reorganization of actin, PDZ (show INADL Antibodies) binding proteins and certain GPCRs.
The co-transfection of the pLuc-CFTR-3 UTR (show UTS2R Antibodies) vector with different combinations of PNAs, miR (show MLXIP Antibodies)-509-3p, and controls in A549 cells demonstrated the ability of the longer PNA to rescue the luciferase activity by up to 70% of the control, thus supporting the use of suitable PNAs to counteract the reduction in the CFTR expression
beta2-Agonist-induced organoid swelling correlated with the CFTR genotype, and could be induced in homozygous CFTR-F508del organoids and highly differentiated primary cystic fibrosis (show S100A8 Antibodies) airway epithelial cells after rescue of CFTR trafficking by small molecules
This paper presents an 11 (show DCAF7 Antibodies)-year-old Chinese CF patient with disseminated bronchiectasis and salty sweat. A homozygous deletion involving exon 20 of CFTR was observed in the patient's genome. This study expands the mutation spectrum of CFTR in patients of Chinese origin.
Authors demonstrated CFTR and PP2AA interact in the cytosol, resulting in PP2A (show PPP2R4 Antibodies) complex inactivation and increased degradation of PP2A (show PPP2R4 Antibodies) substrates via the lysosomal/proteasome pathway.
analysis of CFTR folding mutants and their correction in rectal cystic fibrosis (show S100A8 Antibodies) organoids
Rare CFTR P67L mutation is associated with a mild form of Cystic Fibrosis (show S100A8 Antibodies) compared to the common severe DeltaF508 mutation.
The aim of this study was to sequence the coding region of the CFTR in Brazilian cystic fibrosis (show S100A8 Antibodies) patients and determine the frequency of mutations in this cohort.
With the ongoing development of small molecules to modulate the folding and/or activity of various mutated CFTR proteins, this halide assay presents a small-scale personalized screening platform that could assess therapeutic potential of molecules across a broad range of CFTR mutations
Hsc70 (show HSPA8 Antibodies)/Hsp90 (show HSP90 Antibodies) chaperones contribute to the conformational and functional maintenance of DeltaF508-CFTR at 37 degrees C.
NDPK-A (show NME1 Antibodies) exists in a functional cellular complex with AMPK (show PRKAA2 Antibodies) and CFTR in airway epithelia, and NDPK-A (show NME1 Antibodies) catalytic function is required for the AMPK (show PRKAA2 Antibodies)-dependent regulation of CFTR
Study conclude that when both CFTR and NPT2a are expressed in X. laevis oocytes, CFTR confers to NPT2a a cAMPi-dependent trafficking to the membrane.
wild-type CFTR channel gating cycle is essentially irreversible and tightly coupled to the ATPase (show DNAH8 Antibodies) cycle, and that this coupling is completely destroyed by the NBD2 Walker B mutation D1370N but only partially disrupted by the NBD1 Walker A mutation K464A.
The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that belongs to the superfamily of ATP binding cassette (ABC (show ABCB6 Antibodies)) transporters.
These data suggest that the Xenopus P2Y1 receptor (show P2RY1 Antibodies) can increase both cyclic AMP (show TMPRSS5 Antibodies)/protein kinase A and calcium/protein kinase C (show PKC Antibodies) levels and that the PKC (show PKC Antibodies) pathway is involved in CFTR activation via potentiation of the PKA pathway.
these results demonstrate that CFTR prevents inflammation and atherogenesis via inhibition of NFkappaB and MAPKs activation
CFTR physically interacts with beta-catenin (show CTNNB1 Antibodies), defect of which leads to premature degradation of beta-catenin (show CTNNB1 Antibodies) and suppressed activation of beta-catenin (show CTNNB1 Antibodies) signaling.
CFTR attaches tumor suppressor PTEN to the membrane and promotes anti Pseudomonas aeruginosa immunity.
Our studies reveal a novel function for CFTR in antiviral immunity and demonstrate that the DeltaF508 mutation in cftr is coupled to an impaired adaptive immune response. This important insight could open up new approaches for patient care and treatment.
a new and more convenient approach, based on in vivo imaging analysis, has been set up to evaluate the inflammatory response in the lung of CFTR-deficient (CF) mice, a murine model of cystic fibrosis (show S100A8 Antibodies).
results reveal that by potentiating adenosine triphosphate-sensitive K+ (KATP) channel, cystic fibrosis transmembrane conductance regulator CFTR acts as a glucose-sensing negative regulator of glucagon (show GCG Antibodies) secretion in alpha cells
This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway.
CFTR is a tumor suppressor gene in murine and human colorectal cancer
Insulin (show INS Antibodies) stimulation of Akt1 (show AKT1 Antibodies) and Akt2 (show AKT2 Antibodies) signaling in Cystic fibrosis (show S100A8 Antibodies) airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR.
Biotinylation and streptavidin pull-down assays confirmed that CAL (show S100A11 Antibodies) dramatically reduces the expression level of total and cell surface Mrp2 (show ABCC2 Antibodies) in Huh-7 cells. Our findings suggest that CAL (show S100A11 Antibodies) interacts with Mrp2 (show ABCC2 Antibodies) and is a negative regulator of Mrp2 (show ABCC2 Antibodies) expression.
Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium.
Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness.
Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands.
TGF-beta1 (show TGFB1 Antibodies), via TGF-beta1 (show TGFB1 Antibodies) receptor I and p38 MAPK (show MAPK14 Antibodies) signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.
The esophageal submucosal glands (SMG (show SNRPG Antibodies)) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus.
data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis (show S100A8 Antibodies) are likely primary
The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR.
CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation
These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis (show S100A8 Antibodies) pigs, reveal some spared function in the DeltaF508 vs. null piglets.
causal link between CFTR mutations and partial or total vas (show AVP Antibodies) deferens and/or epididymis atresia at birth
conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I (show DNASE1 Antibodies) hypersensitive sites showed high homology in cow and pig.
Results demonstrate functional coupling between Cftr and Slc26a6 (show SLC26A6 Antibodies)-like Cl(-)/HCO(3)(-) exchange activity in apical membrane of guinea pig pancreatic interlobular duct.
Molecular dynamics of the cryo-EM CFTR structure
Study presents the structure of zebrafish CFTR in the phosphorylated, ATP-bound conformation, determined by cryoelectron microscopy to 3.4 A resolution. Comparison of the two conformations shows major structural rearrangements leading to channel opening.
Study determined the structure of the zebrafish CFTR by electron cryo-microscopy to 3.7 A resolution; shares 55% sequence identity with human CFTR, and 42 of the 46 cystic-fibrosis (show S100A8 Antibodies)-causing missense mutational sites are identical.
Cftr mutant zebrafish develops pancreatic destruction similar to cystic fibrosis (show S100A8 Antibodies) of the human pancreas.
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.
cAMP-dependent chloride channel
, channel conductance-controlling ATPase
, cystic fibrosis transmembrane conductance regulator
, cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
, cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
, ATP-binding cassette sub-family C member 7
, ATP-binding cassette transporter sub-family C member 7
, ATP-binding cassette, subfamily c, member 7
, cystic fibrosis transmembrane conductance regulator homolog
, cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7
, CFTR chloride channel
, chloride channel
, CFTR cAMP-dependent chloride channel protein
, Channel conductance-controlling ATPase