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Sialic acids are a family of nine-carbon sugars on cell surface glycoproteins and glycolipids that play a pivotal role in determining the structure and function of many animal tissues.
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FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.
We show that the two cmas genes most likely originated from the third whole genome duplication, which occurred at the base of teleost radiation.
Sialylation is dispensable for early murine embryonic development in vitro in CMAS-null embryonic stem cells.
The authors provide evidence that the C-terminal domain of CMP-Sialic Acid Synthetase (CSS) serves as a platform for the quaternary organization governing the kinetic properties of the physiologically active enzyme as demonstrated in kinetic studies.[CSS]
Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity
the rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme
Sialic acids are a family of nine-carbon sugars on cell surface glycoproteins and glycolipids that play a pivotal role in determining the structure and function of many animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development and N-glycosylation is a common post-translational modification during cellular differentiation. Sialic acids play important roles in cell-cell communications and immune responses. Sialylated glycoprotein and glycolipid formation requires the activation of a sialic acid to a cytidine monophosphate (CMP) diester by the enzyme encoded by this gene: CMP-N-acetylneuraminic acid synthetase.
cytidine 5'-monophosphate N-acetylneuraminic acid synthetase
, N-acylneuraminate cytidylyltransferase
, CMP-N-acetylneuraminic acid synthase
, CMP-N-acetylneuraminic acid synthetase
, CMP-Neu5Ac synthetase
, CMP-NeuNAc synthase
, CMP-NeuNAc synthetase
, CMP-sialic acid synthetase
, cytidine monophospho-N-acetylneuraminic acid synthetase
, cytidine monophosphate sialic acid synthetase 1
, putative CMP-sialic acid synthetase
, cytidine monophosphate N-acetylneuraminic acid synthetase
, CMP-Neu5Ac synthase