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Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. Additionally we are shipping CYBB Kits (11) and CYBB Proteins (6) and many more products for this protein.
Showing 10 out of 114 products:
Human Polyclonal CYBB Primary Antibody for IF (cc), IF (p) - ABIN750688
Dalaklioglu, Tasatargil, Kale, Tanriover, Dilmac, Erin: Metastatic breast carcinoma induces vascular endothelial dysfunction in Balb-c mice: Role of the tumor necrosis factor-? and NADPH oxidase. in Vascular pharmacology 2013
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Mouse (Murine) Monoclonal CYBB Primary Antibody for IF, WB - ABIN968524
Jacobsen, Skalnik: YY1 binds five cis-elements and trans-activates the myeloid cell-restricted gp91(phox) promoter. in The Journal of biological chemistry 1999
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Human Polyclonal CYBB Primary Antibody for IHC (p), WB - ABIN3044252
Liao, Liu, Guo, Zhang, Zhang: Oxidative burst of circulating neutrophils following traumatic brain injury in human. in PLoS ONE 2013
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Human Polyclonal CYBB Primary Antibody for IHC, IHC (p) - ABIN4301440
Rajtik, Carnicka, Szobi, Giricz, O-Uchi, Hassova, Svec, Ferdinandy, Ravingerova, Adameova: Oxidative activation of CaMKIIδ in acute myocardial ischemia/reperfusion injury: A role of angiotensin AT1 receptor-NOX2 signaling axis. in European journal of pharmacology 2016
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Mouse (Murine) Monoclonal CYBB Primary Antibody for IF, WB - ABIN968523
Suzuki, Kumatori, Haagen, Fujii, Sadat, Jun, Tsuji, Roos, Nakamura: PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes. in Proceedings of the National Academy of Sciences of the United States of America 1998
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Human Monoclonal CYBB Primary Antibody for ICC, IF - ABIN1042596
Burritt, Quinn, Jutila, Bond, Jesaitis: Topological mapping of neutrophil cytochrome b epitopes with phage-display libraries. in The Journal of biological chemistry 1995
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Human Polyclonal CYBB Primary Antibody for ELISA, IHC - ABIN4301436
Zhu, Lindsey, Konieczna, Eklund: Constitutive activation of SHP2 protein tyrosine phosphatase inhibits ICSBP-induced transcription of the gene encoding gp91PHOX during myeloid differentiation. in Journal of leukocyte biology 2008
Human Monoclonal CYBB Primary Antibody for WB - ABIN1042597
Baniulis, Burritt, Taylor, Dinauer, Heyworth, Parkos, Magnusson, Jesaitis: Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox. in European journal of haematology 2005
The nox1 (show NOX1 Antibodies), nox2/cybb expression in zebrafish during early nervous system development from 12 to 48 hours post fertilization
Data indicate that NADPH oxidase (show NOX1 Antibodies) NOx2 inhibition attenuates endoplasmic reticulum (ER) stress and apoptosis.
Nox2 activity efficiently contributes to the mechanism of oxidative stress-induced (show SQSTM1 Antibodies) increase in premature aging conferred by doxorubicin. The importance of modulation of Nox2 in human EPCs could reveal a useful tool to restore endothelial progenitor cells physiological function and properties.
We examined the pattern of NOX expression in spinal cords of patients and mouse models of ALS (show IGFALS Antibodies) and analyzed the impact of genetic deletion of the NOX1 (show NOX1 Antibodies) and 2 isoforms as well as pharmacological NOX inhibition in the SOD1 (show SOD1 Antibodies)(G93A) ALS (show IGFALS Antibodies) mouse model.In contrast to previous publications, survival of SOD1 (show SOD1 Antibodies)(G93A) mice was not modified upon breeding with constitutive NOX1 (show NOX1 Antibodies) and NOX2 deficient mice.
Recent studies reveal that AKT2 (show AKT2 Antibodies)-NOX2 signaling has critical roles in Ca mobilization, ROS (show ROS1 Antibodies) generation, degranulation, and control of the ligand-binding function of cell surface molecules, thereby promoting heterotypic cell-cell interactions in thromboinflammation.
Study demonstrate that Nox2 signaling via inactivation of phosphatase and tensin homolog (show PTEN Antibodies) and activation of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway leads to membrane ruffling and macropinocytosis.
Our findings indicate that Nox2 deficiency results in exaggerated experimental asthma, which is caused by enhanced Th2 effector function in a T-cell-intrinsic manner.
In a family study of a patient with chronic granulomatous disease, the mutation in the CYBB gene was confirmed to be pathogenic, and the three variants in the CYBA (show CYBA Antibodies) gene were benign.
Finally, overexpression of miR34a in EBNA1 (show EBNA-1 Antibodies)-expressing SNU719 cells induced typical apoptosis, suggesting that reactivation of miR34a in EBNA1 (show EBNA-1 Antibodies)-expressing gastric cancer cells could be a strategy for treatment of EBV-infected gastric cancer cells.
NOX2 expression was significantly higher in the cortex of asphyctic suicide subjects than in non-suicidal asphyxia and controls.
Acute myeloid leukemia (show BCL11A Antibodies) cells -derived NOX2 drives transfer of mitochondria via the generation of superoxide.
NOX2, NOX4 (show NOX4 Antibodies), and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 (show ANGPT1 Antibodies) signaling and angiogenic responses in endothelial cells.
Data indicate that the efficiency of NADPH oxidase (show NOX1 Antibodies) enzymatic activity is higher at endoplasmic reticulum (ER).
A p47(phox) and Src kinase (show CSK Antibodies) activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C (show PKC Antibodies)
this study shows that neutrophil pyroptosis mediates pathology of Pseudomonas aeruginosa lung infection in the absence of the NADPH oxidase (show NOX1 Antibodies) NOX2
Data indicate that increased NADPH oxidase (show NOX1 Antibodies) activity after traumatic brain injury drives M1-like activation in microglia/macrophages that contributes to inflammatory-mediated neurodegeneration.
Neurofibromin (show NF1 Antibodies) regulates macrophage superoxide production via p21Ras.Neurofibromin-deficient smooth muscle cells are sensitive to oxidative stress.NADPH oxidase 2 is required for NF1 (show NF1 Antibodies) arterial stenosis.Neurofibromatosis type 1 patients have evidence of chronic oxidative stress.
We examined the pattern of NOX expression in spinal cords of patients and mouse models of ALS and analyzed the impact of genetic deletion of the NOX1 (show NOX1 Antibodies) and 2 isoforms as well as pharmacological NOX inhibition in the SOD1 (show SOD1 Antibodies)(G93A) ALS mouse model.In contrast to previous publications, survival of SOD1 (show SOD1 Antibodies)(G93A) mice was not modified upon breeding with constitutive NOX1 (show NOX1 Antibodies) and NOX2 deficient mice.
Spinal cord injury leads to a significant increase in NOX2 expression. The reduction in M2 polarization is associated with a peak in NOX2 expression.
NOX2 has a role in leukocyte activation and in thrombus formation
mice deficient in reactive oxygen species production by NOX2 due to the absence of the gp91 (show LILRB3 Antibodies) subunit had significantly more severe pathology in the later stages of infection with Leishmania amazonensis
indicate that following traumatic brain injury NOX2 inhibition promotes a robust anti-inflammatory response in macrophages/microglia that is mediated by the IL-10 (show IL10 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathway
The results suggest that Nrf2 (show NFE2L2 Antibodies) is an important regulator of the retinal milieu during tissue ischemia, and that the Nrf2 (show NFE2L2 Antibodies)/NOX2 balance may play a critical role in determining the fate of ischemic revascularization.
North American ginseng inhibits myocardial NOX2-ERK1/2 (show MAPK1/3 Antibodies)-TNF-alpha (show TNF Antibodies) signaling pathway and improves cardiac function in endotoxemia, suggesting that NA ginseng may have the potential in the prevention of clinical sepsis.
These results suggested that resveratrol strongly enhances the RA-induced O2(-)-generating activity via up-regulation of gp91-phox gene expression in U937 cells.
sub-vasomotor concentration of ET-1 (show EDN1 Antibodies) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Antibodies) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Antibodies) following ETA receptor activation
Reactive oxygen species generated by NADPH oxidase (show NOX1 Antibodies) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.
Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis.
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase\; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
cytochrome b-245, beta polypeptide
, NADPH oxidase 2
, cytochrome b-245, beta polypeptide (chronic granulomatous disease)
, Cytochrome b-245 heavy chain
, NADPH oxidase heavy chain subunit
, NADPH oxidase 1
, NADPH oxidase flavocytochrome b subunit
, cytochrome b-245 heavy chain
, cytochrome b(558) subunit beta
, cytochrome b558 subunit beta
, heme-binding membrane glycoprotein gp91phox
, neutrophil cytochrome b 91 kDa polypeptide
, p22 phagocyte B-cytochrome
, superoxide-generating NADPH oxidase heavy chain subunit
, endothelial type gp91-phox
, predicted NADPH oxidase-2