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CYP2A6, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP2A6 Antibodies (120) and CYP2A6 Proteins (3) and many more products for this protein.
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Polymorphisms within the CYP2A6 gene are not a significant cause of high skatole levels.
The aim of this study was to investigate the effects of the interaction between the CYP (show PPIG ELISA Kits) 2A6 and COMT (show COMT ELISA Kits) genes on smoking behavior in young Taiwanese men. The odds ratio for starting smoking was significantly lower in subjects carrying a CYP2A6 low activity/variant COMT (show COMT ELISA Kits) rs4680 genotype than in those possessing a CYP2A6 wild-type/variant COMT (show COMT ELISA Kits) rs4680 genotype (0.44, 95% confidence interval = 0.19-0.98, P = 0.043).
genetic association studies in population in China: Data suggest that SNPs in CYP2C9 and CYP2A6 are associated with hepatotoxicity due to antiepileptic drug valproate in the population studied. (CYP2C9 = cytochrome P450 family 2 subfamily C member 9; CYP2A6 = cytochrome P450 family 2 subfamily A member 6)
Our results demonstrated the presence of functional variability in CYP2a6 activities resulting from amino acid substitutions caused by genetic polymorphisms.
Cynomolgus monkey CYP2A24, which shows 95% amino acid identity to human CYP2A6.
CYP2A6 rs60823196 and rs138978736 are possible risk factors for serious toxicity in Chinese gastric carcinoma patients treated with S-1 plus oxaliplatin chemotherapy.
findings suggest that CYP1A2 alleles or haplotypes were not predictive of metabolic phenotypes in the Nigerian population; carriers of CYP2A6*9/*17 genotype are likely to be poor metabolisers of CYP2A6 substrates and may experience adverse reactions or poor efficacy while using drugs metabolised mainly by CYP2A6
Genetic polymorphisms in CYP2B6 and CYP2A6 explained a significant proportion of variability in EFV plasma concentration in HIV-infected children in a multi-ethnic outpatient clinic.
In a Mexican Mestizo population, rs1137115(A) and rs4105144(T) in CYP2A6 are associated with cigarette consumption
CYP2B6/CYP2A6 genotypes were associated with increased reported suicidality among AIDS patients who had been randomly assigned to receive efavirenz-containing regimens in clinical trials. Strength of association varied by race/ethnicity.
The CYP2A6 gene product plays a major role in the nicotine metabolism pathway, which influences nicotine intake.
This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3\; however, it has been renamed CYP2A6.
, cytochrome p450 2A6
, 1,4-cineole 2-exo-monooxygenase
, cytochrome P450 2A6
, cytochrome P450 IIA3
, cytochrome P450(I)
, cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6
, flavoprotein-linked monooxygenase
, xenobiotic monooxygenase