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Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 Proteins (CYP4B1)

CYP4B1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 Antibodies (41) and Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP4B1 1580 P13584
CYP4B1 13120 Q64462
CYP4B1 24307 P15129
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Top Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$554.07
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,448.50
Details

CYP4B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 (CYP4B1) Interaction Partners

Rabbit Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 (CYP4B1) interaction partners

  1. P450 (show POR Proteins) 4B1 exhibits structural adaptations for omega-hydroxylation that include changes in the conformation of the heme and changes in a highly conserved helix I motif that is associated with selective oxygenation of unactivated primary C-H bonds.

  2. A co-crystal structure of the rabbit family 4 enzyme CYP4B1 with its substrate octane reveals that the propensity for omega-hydroxylation is orchestrated by active-site sterics, partially mediated by an unusual heme-polypeptide ester bond.

  3. spectral binding affinities and oxidative metabolism of the furan analogs by the purified recombinant CYP4B1 variants were analyzed: the naturally occurring perilla ketone was found to be the tightest binder to CYP4B1, but also the analog that was most extensively metabolized by oxidative processes to numerous non-reactive reaction products.

  4. A proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-ipomeanol bioactivation.

  5. results strongly implicate the corneal CYP4B1 as a component of the inflammatory and neovascular cascade initiated by injury and further suggest that CYP4B1-12-HETrE is a proximal regulator of VEGF (show VEGFA Proteins) expression

Human Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 (CYP4B1) interaction partners

  1. the Ser207 insertion does not rescue the P450 (show CYP2B6 Proteins) functional activity of human CYP4B1 that has been lost during evolution.

  2. Single nucleotide polymorphisms of CYP2C8,CYP2E1 and CYP4B1 are associated with susceptibility to gout in ethnic Han males population.

  3. A proline residue in the meander region at position 427 in human CYP4B1 and 422 in rabbit CYP4B1 is important for protein stability and rescues the 4-ipomeanol bioactivation.

  4. CYP4B1 is a senescene-associated gene in normal human oral keratinocytes.

  5. Results demostrated an increased risk of bladder cancer associated with the CYP4B1*1/*2 and *2/*2 genotypes.

  6. Detected by polymerase chain reaction in prostate tissue.

Mouse (Murine) Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 (CYP4B1) interaction partners

  1. Data show that the 5' flanking region of the Cyp4b1 gene exhibits promoter activity when expressed in different cell lines and that a 98-truncated fragment represents the minimal sequence required for basal transcription.

  2. Increased CYP4B1 mRNA is associated with the inhibition of dextran sulfate sodium-induced colitis by caffeic acid in mice.

Cytochrome P450, Family 4, Subfamily B, Polypeptide 1 (CYP4B1) Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens\; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene.

Gene names and symbols associated with CYP4B1

  • cytochrome P450, family 4, subfamily B, polypeptide 1 (CYP4B1)
  • CYP4B1-like isozyme short form (CYP4B1)
  • cytochrome P450, family 4, subfamily B, polypeptide 1 L homeolog (cyp4b1.L)
  • cytochrome P450, family 4, subfamily B, polypeptide 1 (cyp4b1)
  • cytochrome P450 family 4 subfamily B member 1 (CYP4B1)
  • cytochrome P450, family 4, subfamily b, polypeptide 1 (Cyp4b1)
  • CYPIVB1 protein
  • P-450HP protein

Protein level used designations for CYP4B1

cytochrome P450 4B1 , CYP4B1 isoform , CYPIVB1 , P450-isozyme 5 , cytochrome P450 isozyme 5 , cytochrome P450, family 4, subfamily B, polypeptide 1 , cytochrome P450 XL-304 , cytochrome P450, subfamily IVB, polypeptide 1 , cytochrome P450-HP , microsomal monooxygenase , cytochrome P450, subfamily IV B, polypeptide 1 , P450 L-2 , cytochrome P450 L-2 , cytochrome P450, subfamily 4B, polypeptide 1

GENE ID SPECIES
540149 Bos taurus
100008805 Oryctolagus cuniculus
100036772 Xenopus laevis
100145080 Xenopus (Silurana) tropicalis
1580 Homo sapiens
13120 Mus musculus
24307 Rattus norvegicus
608452 Canis lupus familiaris
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