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The protein encoded by CYTH2 is a member of the PSCD family. Additionally we are shipping Cytohesin 2 Antibodies (82) and Cytohesin 2 Proteins (10) and many more products for this protein.
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ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.
Authors' experiments argue against ARNO being a robust modifier of EGFR (show EGFR ELISA Kits) catalytic activity.
Data establish a role for cytohesin-2/ARNO as a regulator of R-Ras and integrin recycling and suggest that ARF-regulated trafficking of R-Ras is required for R-Ras-dependent effects on spreading and adhesion formation.
The authors show that Shigella flexneri IpgD phosphatase activity is required for recruitment of the ARF6 (show ARF6 ELISA Kits) guanine nucleotide exchange factor (show RASGRF1 ELISA Kits) (GEF) ARF nucleotide binding site opener (ARNO) to bacterial entry sites.
inhibiting cytohesins or ARNO as cytoplasmic activators of EGFR (show EGFR ELISA Kits) and IGF-I (show IGF1 ELISA Kits) in colorectal cancer resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth in vivo and in vitro.
Cytohesin-2 constitutively suppresses platelet dense granule secretion and aggregation by keeping ARF6 (show ARF6 ELISA Kits) in a GTP (show AK3 ELISA Kits)-bound state
Expression of CYTH2 mutant deficient of the EFh2 domain in cells also inhibits Arf6 (show ARF6 ELISA Kits) activation and neurite extension.
Phosphorylation of Ser392 of ARNO stabilized the C-terminal alpha-helix via formation of salt bridges between phospho-Ser392 and Arg390, Lys395, and Lys396.
There is an association between cytohesin-2 expression and overall survival and disease-free survival in patients with hepatocellular carcinoma.
Arf6 (show ARF6 ELISA Kits)/ ARNO signaling mediates phospholipase-D (show PLD ELISA Kits), ERK1/2 (show MAPK1/3 ELISA Kits) and cofilin (show CFL1 ELISA Kits) activation in pancreatic beta-cells.
results show that ARNO interaction with the RLIP76 (show RALBP1 ELISA Kits) N-terminus regulates cell spreading and motility via PI3K and Arf6 (show ARF6 ELISA Kits), independent of RLIP76 (show RALBP1 ELISA Kits) control of Rac (show AKT1 ELISA Kits)
The RLIP76 (show RALBP1 ELISA Kits)/R-Ras/ARNO complex localizes to recycling endosomes.
signaling through cytohesin-2 is required for myelination by Schwann cells, and cytohesin-2 is added to the list of molecules known to underlie PNS myelination
results together suggest that cytohesin 2 activates ARF6 (show ARF6 ELISA Kits) in a PI3K dependent manner and then the active ARF6 (show ARF6 ELISA Kits) causes phosphorylation of ERK1/2 (show MAPK1/3 ELISA Kits) during preadipocyte migration.
The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (V-ATPase (show DNAH8 ELISA Kits)) and cytohesin-2
role for endothelial ARNO in VEGF (show VEGFA ELISA Kits)-dependent initiation of angiogenesis by regulation of VEGFR-2 (show KDR ELISA Kits) internalization in endothelial cells, resulting in the activation of the Akt (show AKT1 ELISA Kits) pathway, vessel permeability, and ultimately endothelial proliferation
cytohesin-2, through a previously unexplored complex formation with paxillin, regulates preadipocyte migration; paxillin plays a previously unknown role as a scaffold protein of Arf guanine-nucleotide exchange factor
Specific motifs of the V-ATPase a2 (show ATP6V0A2 ELISA Kits)-subunit isoform interact with catalytic and regulatory domains of ARNO.
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene.
, cytohesin 2
, pleckstrin homology, Sec7 and coiled/coil domains 2
, pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)
, ARF exchange factor
, ARF nucleotide-binding site opener
, PH, SEC7 and coiled-coil domain-containing protein 2
, pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2)
, ARF nucleotide binding site opener
, SEC7 homolog B
, pleckstrin homology, Sec7 and coiled-coil domains 2