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DBF4B encodes a regulator of the cell division cycle 7 homolog (S.
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Results describe a novel human protein, Drf1, related to both human and yeast Dbf4 (show DBF4 Antibodies). Drf1 is a nuclear cell cycle-regulated protein which binds to Cdc7 (show CDC7 Antibodies) and activates the kinase.
ASKL1 in a complex with Cdc7 (show CDC7 Antibodies) may play a role in normal progression of both S and M phases
Inhibition of Drf1 is the primary mechanism by which Chk1 (show CHEK1 Antibodies) blocks cell-cycle progression in the early embryo and is an essential function of Chk1 (show CHEK1 Antibodies) at the blastula-to-gastrula stage of development.
This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants.
DBF4 homolog B (S. cerevisiae)
, ASK-like protein 1
, Dbf4-related factor 1
, activator of S-phase kinase-like protein 1
, chiffon homolog B
, protein DBF4 homolog B
, zinc finger, DBF-type containing 1B