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Part of an E3 ubiquitin ligase complex for neddylation.
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Human Polyclonal DCUN1D1 Primary Antibody for ELISA, IHC - ABIN4304542
Villa, Venturelli, Fenoglio, Clerici, Marcone, Benussi, Gallone, Scalabrini, Cortini, Serpente, Martinelli Boneschi, Cappa, Binetti, Mariani, Rainero, Giordana, Bresolin, Scarpini, Galimberti: DCUN1D1 is a risk factor for frontotemporal lobar degeneration. in European journal of neurology 2009
Human Polyclonal DCUN1D1 Primary Antibody for ICC, IF - ABIN4304544
Chen, McGee, Chen, Doman, Gong, Zhang, Hamm, Ma, Higgs, Bhagwat, Buchanan, Peng, Staschke, Yadav, Yue, Kouros-Mehr: Identification of druggable cancer driver genes amplified across TCGA datasets. in PLoS ONE 2014
We also found that both miR (show MLXIP Antibodies)-195 and DCUN1D1 siRNAs can inhibit cell invasion possibly through downregulating Matrix metalloproteinase-2 (MMP-2 (show MMP2 Antibodies)) and Matrix metalloproteinase-9 (MMP-9 (show MMP9 Antibodies)) at the post-transcriptional level, which can be attenuated by restoring the expression of DCUN1D1
The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity.
SCCRO3 functions as a tumor suppressor by antagonizing the neddylation activity of SCCRO
Distinct preferences of UBC12 (show ube2m Antibodies) and UBE2F (show UBE2F Antibodies) peptides for inhibiting different DCNLs, including the oncogenic DCNL1.
substrate engagement prompts DCNL1 recruitment that facilitates the initiation of CUL2 (show CUL2 Antibodies) neddylation and define DCNL1 as a "substrate sensor switch" for ECV activation.
a mono-ubiquitination-mediated mechanism that governs nuclear-cytoplasmic trafficking of hDCNL1, thereby regulating hDCNL1-dependent activation of the cullin-RING E3 ubiquitin ligases in selected cellular compartments.
Loss of SCRO expression in primary adrenocortical carcinoma is associated with worse outcome and may be a marker of progressive dedifferentiation in these tumors.
SCCRO regulates Gli1 (show GLI1 Antibodies)--a key regulator of the hedgehog (show SHH Antibodies) (HH) pathway.
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
SCCRO-induced invasion involves activation of MMP2 (show MMP2 Antibodies) transcription in an AP2 (show GTF3A Antibodies)- and p53 (show TP53 Antibodies)-dependent manner.
Data (including data from studies using cells cultured from knockout mice) suggest that Sccro neddylates Cul3 (show CUL3 Antibodies) with Nedd8 (show NEDD8 Antibodies), promoting Cul3 (show CUL3 Antibodies)/Klhl21 (show KLHL21 Antibodies) complex formation and localization of Cul3 (show CUL3 Antibodies) during telophase. (Sccro = squamous cell carcinoma-related oncogene (show DCUN1D2 Antibodies); Cul3 (show CUL3 Antibodies) = cullin 3 (show CUL3 Antibodies); Nedd8 (show NEDD8 Antibodies) = neural precursor cell expressed, developmentally down-regulated protein 8; Klhl21 (show KLHL21 Antibodies) = kelch-like protein 21 (show KLHL21 Antibodies))
SCCRO family members cooperatively regulate neddylation and cell proliferation.
in the nucleus, SCCRO enhances recruitment of Ubc12 (show ube2m Antibodies) to Cul1 (show CUL1 Antibodies) to promote neddylation
SCCRO promotes glioma formation and malignant progression.
Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).
DCN1-like protein 1
, DCUN1 domain-containing protein 1
, RP42 homolog
, defective in cullin neddylation protein 1-like protein 1
, squamous cell carcinoma related oncogene
, squamous cell carcinoma-related oncogene
, testis derived transcript 3
, testis-specific protein 3