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Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Additionally we are shipping DCTPP1 Antibodies (28) and DCTPP1 Kits (7) and many more products for this protein.
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Hypermethylation of CpG islands in MDR1 gene promoter region is obvious in DCTPP1-knockdown BGC-823 gastric cancer (GC) cells.
DCTPP1 has a central role in the balance of dCTP and the metabolism of deoxycytidine analogues.
Human dCTP pyrophosphatase 1 binds and is inhibited by the small molecule triptolide in vitro.
Several key residues involved in the substrate binding of RS21-C6 have been identified.
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).
XTP3-transactivated gene A protein
, XTP3-transactivated protein A
, dCTPase 1
, deoxycytidine-triphosphatase 1
, XTP3-transactivated gene A protein homolog
, dCTP pyrophosphatase 1