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DCAF8 encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex.
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DCAF8 p.R317C mutation is responsible for specific variety of HMSN2 with infrequent giant axons and mild cardiomyopathy.
WDR42A is a nucleocytoplasmic shuttling protein.
while RNF10 (show RNF10 Proteins) and WDR42A or VP22 alone showed distinct subcellular localization patterns, RNF10 (show RNF10 Proteins) and WDR42A were relocated when co-expressed with VP22 or its homologues; these potential host cell factors of VP22 might expand the list of host targets of VP22
This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene.
DDB1 and CUL4 associated factor 8
, WD repeat domain 42A
, DDB1- and CUL4-associated factor 8
, WD repeat-containing protein 42A