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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Additionally we are shipping DDX21 Proteins (5) and and many more products for this protein.
Showing 10 out of 70 products:
Cow (Bovine) Polyclonal DDX21 Primary Antibody for WB - ABIN2775198
Henning, So, Jin, Lau, Valdez: Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. in The Journal of biological chemistry 2003
Show all 3 Pubmed References
Horse (Equine) Polyclonal DDX21 Primary Antibody for WB - ABIN2775197
Yang, Henning, Valdez: Functional interaction between RNA helicase II/Gu(alpha) and ribosomal protein L4. in The FEBS journal 2005
Show all 3 Pubmed References
Human Polyclonal DDX21 Primary Antibody for ChIP, ICC - ABIN4304615
Obrdlik, Louvet, Kukalev, Naschekin, Kiseleva, Fahrenkrog, Percipalle: Nuclear myosin 1 is in complex with mature rRNA transcripts and associates with the nuclear pore basket. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
Show all 2 Pubmed References
Human Polyclonal DDX21 Primary Antibody for ICC, IF - ABIN151240
Song, Hotz-Wagenblatt, Voit, Grummt: SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. in Genes & development 2017
Human Polyclonal DDX21 Primary Antibody for WB - ABIN1539008
Smith, Krumpelbeck, Jegga, Prell, Matrka, Kappes, Greis, Ali, Meetei, Wells: The nuclear DEK interactome supports multi-functionality. in Proteins 2018
Knockdown of SIRT7 (show SIRT7 Antibodies) leads to the same phenotype as depletion of DDX21 (i.e., increased formation of R loops and DNA double-strand breaks), indicating that SIRT7 (show SIRT7 Antibodies) and DDX21 cooperate to prevent R-loop accumulation, thus safeguarding genome integrity.
DDX21 can suppress the expression of proteins with G4 qudruplexes in the 3 UTR (show UTS2R Antibodies) of its mRNA.
Results report the biogenesis and function of a box H/ACA snoRNA-ended sno-lncRNA, referred to SLERT (snoRNA-ended lncRNA enhances pre-ribosomal RNA transcription). SLERT is different from Prader-Willi Syndrome (PWS) sno-lncRNAs and plays a crucial role in rRNA biogenesis by dislodging a previously unknown clamp of DDX21 ring-shaped arrangements on Pol I complexes, thereby liberating Pol I for active rRNA transcription.
In dengue virus infected cells, DDX21 translocates from nucleus to cytoplasm to active the innate immune response and thus inhibits DENV replication in the early stages of infection.
DDX21 expression in breast cancer cells can promote AP-1 (show FOSB Antibodies) activity and rRNA processing, and thus, promote tumorigenesis by two independent mechanisms.
Identification of several late-acting snoRNAs that bind pre-40S particles in human cells and show that their association and function in pre-40S complexes is regulated by the RNA helicase (show DDX46 Antibodies) DDX21.
results uncover the multifaceted role of DDX21 in multiple steps of ribosome biogenesis, and provide evidence implicating a mammalian RNA helicase (show DDX46 Antibodies) in RNA modification and Pol II (show Pol II Antibodies) elongation control
As sequential interaction of PB1 and NS1 with DDX21 leads to temporal regulation of viral gene expression, influenza A virus likely uses the DDX21-NS1 interaction not only to overcome restriction, but also to regulate the viral life cycle.
Data indicate that DDX21, a nucleolar protein (show MCRS1 Antibodies), was confirmed to associate with SET8 (show SETD8 Antibodies).
Studies indicated that DDX21, HNRNPC (show HNRNPC Antibodies), and RCC2 (show RCC2 Antibodies) were isolated from Ku86 (show XRCC5 Antibodies) multicomponent complex in response to DNA damage.
TLR4 (show TLR4 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury.
a previously unknown function of the DDX21-TRIF (show RNF138 Antibodies)-S100A9 (show S100A9 Antibodies)-TLR4 (show TLR4 Antibodies)-MyD88 (show MYD88 Antibodies) signaling network in regulating inflammation during infection.
DDX1 (show DDX1 Antibodies)-DDX21-DHX36 (show DHX36 Antibodies) complex represents a dsRNA sensor that uses the TRIF (show RNF138 Antibodies) pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells
RNA helicase II (show ATRX Antibodies)/Gualpha silencing inhibits mammalian ribosomal RNA production
in addition to its transcriptional effects, c-Jun (show JUN Antibodies) regulates rRNA processing and nucleolar compartmentalization of the rRNA processing protein DDX21
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
, RNA helicase II/Gu
, novel GUCT (NUC152) domain containing DEAD/DEAH box helicase
, nucleolar RNA helicase 2
, DEAD box protein 21
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21
, Gu protein
, RH II/Gu
, RNA helicase II/Gu alpha
, nucleolar RNA helicase Gu
, nucleolar RNA helicase II
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 21a
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 (RNA helicase II/Gu)