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DHX9 encodes a member of the DEAH-containing family of RNA helicases.
Showing 7 out of 8 products:
Human Polyclonal DHX9 Primary Antibody for ICC, IF - ABIN258213
Watashi, Yeung, Starost, Hosmane, Jeang: Identification of small molecules that suppress microRNA function and reverse tumorigenesis. in The Journal of biological chemistry 2010
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Human Polyclonal DHX9 Primary Antibody for IHC (p), IHC - ABIN258212
Xing, Niu, Zhao, Kleiman: Different activities of the conserved lysine residues in the double-stranded RNA binding domains of RNA helicase A in vitro and in the cell. in Biochimica et biophysica acta 2014
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Human Polyclonal DHX9 Primary Antibody for ELISA, WB - ABIN451752
Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. in Cancer research 2006
our study supports the presence of a p53 (show TP53 Antibodies)-independent mechanism of cell death and cell cycle arrest resulting from DHX9 inhibition. our results support the feasibility of targeting DHX9 as a chemotherapeutic approach in p53 (show TP53 Antibodies)-deficient tumors.
study identified the RNA helicase DHX9 as a regulator of pRNA processing; DHX9 binds to rRNA genes only upon embryonic stem cells differentiation and its activity guides TIP5 to rRNA genes and establishes heterochromatin
the decreased growth of osteosarcoma cells by MCM2 or MCM3 knockdown was reversed by DHX9 overexpression, indicating that MCM2 and MCM3 activity was DHX9-dependent.
analysis of the structure, biochemistry, and biology of DHX9, its role in cancer and other human diseases [review]
RNA helicase (show DDX46 Antibodies) A was shown to cooperate with both tumor suppressors and oncoproteins in different tumours, indicating that its specific role in cancer is strongly influenced by the cellular context.
Importantly, binding of Nup98 to DHX9 stimulates the ATPase activity of DHX9, and a transcriptional reporter assay suggests Nup98 supports DHX9-stimulated transcription.
Our results demonstrate a robust tolerance for systemic DHX9 suppression in vivo and support the targeting of DHX9 as an effective and specific chemotherapeutic approach.
an evolutionarily conserved function of DHX9, it acts as a nuclear RNA resolvase that neutralizes the immediate threat posed by Alu transposon insertions and allows these elements to evolve as tools for the post-transcriptional regulation of gene expression
study provides evidence demonstrating that the PRRSV nucleocapsid protein interacts with Nsp9 and its RNA-dependent RNA-polymerase domain and also recruits the cellular helicase DHX9 during virus infection to facilitate viral RNA synthesis and virus production
Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9.
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.
ATP-dependent RNA helicase A
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9
, DEAH (Asp-Glu-Ala-His) box polypeptide 9
, DEAH box protein 9
, RNA helicase A
, nuclear DNA helicase II