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DND1 encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Additionally we are shipping Dead End Homolog 1 (Zebrafish) Proteins (2) and many more products for this protein.
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DND1 binds a UU(A/U) trinucleotide motif predominantly in the 3' untranslated regions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4 (show CCR4 Antibodies)-NOT deadenylase complex.
DND1 interacts with NANOS2 to load unique RNAs into the CCR4-NOTdeaden complex; this interaction is mediated by the zinc finger domain of NANOS2, which is essential for its association with target RNAs; DND1 is an essential partner for NANOS2 that leads to the degradation of specific RNAs in male germ cell development
Dnd1 heterozygotes, lower oxygen availability was associated with metabolic differences
APOBEC3G (show APOBEC3G Antibodies) inhibits DND1 function to regulate microRNA activity.
results show that Dnd1 is essential for normal allelic inheritance and that Dnd1Ter has a novel combination of functions that significantly increase risk for both testicular and intestinal cancer
DND1 is the first protein known to have an RNA recognition motif directly implicated as a heritable cause of spontaneous tumorigenesis
DND1-alpha isoform to be necessary for germ cell viability and its loss in Ter (show TECR Antibodies) mice results in germ cell depletion, germ cell tumor development and partial embryonic lethality in the 129 strain.
The role of dead-end in germ-cell tumor development.
The interaction of DND1 and APOBEC3 could be one mechanism for maintaining viability of germ cells and for preventing germ cell tumor development
when Dnd1(Ter/Ter) XX germ cells developed in a testicular environment they gave rise to the same neoplastic clusters as mutant XY germ cells in a testis.
Mechanistically, Dnd1 could bind to 3'-UTR (show UTS2R Antibodies) of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP (show YAP1 Antibodies) and its cytoplasmic retention.
Dnd1 facilitates apoptosis by increasing the expression of Bim (show BCL2L11 Antibodies) via its competitive combining with miR (show MLXIP Antibodies)-221 in Bim-3'UTR (show UTS2R Antibodies).
RBM38 (show RBM38 Antibodies) and DND1 are repressed in primary acute myeloid leukemia (show BCL11A Antibodies), neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1 (show CDKN1A Antibodies)) expression during acute promyelocytic leukemia (show PML Antibodies) differentiation
The increased sensitivity of transformed keratinocytes to miR (show MLXIP Antibodies)-21's effects occurs in part through downregulation of the RNA-binding protein (show PTBP1 Antibodies) DND1 during the transformation process.
Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells.
We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility
Cloning of zebrafish dnd1 and identification of human DND1 by database analysis.
Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression.
MiR (show MLXIP Antibodies)-24 up-regulation reduced the expression of RNA-binding protein (show PTBP1 Antibodies) dead end 1 (show VPS11 Antibodies) (DND1). Knockdown of miR (show MLXIP Antibodies)-24 led to enhanced expression of DND1.
This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17.
dead end homolog 1
, dead end homolog 1 (zebrafish)
, dead end protein homolog 1-like
, dead end protein homolog 1
, RNA-binding motif, single-stranded-interacting protein 4