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DENR encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest.
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DENR binds to the P-site of the 40S ribosomal subunit and together with MCTS1 (show MCTS1 Proteins) forms a tRNA binding surface and interfere with eIF1 (show EIF1 Proteins)/eIF2 (show EIF2S1 Proteins)/eIF3 (show EIF3A Proteins) binding, thus operating in ribosome recycling and translation re-initiation
Reinitiation complexes involving initiation factors eIF2D (show EIF2D Proteins), MCT-1 (show CMA1 Proteins), and DENR controls the translation of a large fraction of mammalian cellular mRNAs.
both HuR (show ELAVL1 Proteins) and AUF1 (show HNRNPD Proteins) bind to discrete regions of DENR/DRP mRNA and that AUF1 (show HNRNPD Proteins) silencing increases DENR/DRP protein levels.
Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1 (show MCTS1 Proteins).
This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants.
smooth muscle cell associated protein-3
, smooth muscle cell-associated protein 3
, density-regulated protein
, Density-regulated protein