anti-Deoxycytidine Kinase (DCK) Antibodies

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Additionally we are shipping DCK Kits (17) and DCK Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DCK 1633 P27707
DCK 79127 P48769
DCK 13178 P43346
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Top anti-DCK Antibodies at antibodies-online.com

Showing 10 out of 153 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-DCK Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Human heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-DCK Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: DCK Antibody [NBP2-16108] - DCK antibody detects DCK protein at cytosol on Saos2 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded Saos2 xenograft. DCK antibody dilution: 1:500. Western Blot: DCK Antibody [NBP2-16108] - Sample (30 ug of whole cell lysate) A: 293T B: A431 C: HeLa D: HepG2 12% SDS PAGE gel, diluted at 1:10000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$522.50
Details
Human Rabbit Un-conjugated IP, IHC (p), WB IHC-P Image DCK antibody detects DCK protein at nucleus on mouse hind brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse hind brain. DCK antibody , dilution: 1:500. WB Image DCK antibody detects DCK protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with DCK antibody , diluted at a dilution of 1:5000. 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Deoxycytidine kinase, antibody at 1:200 dilution. WB Image DCK antibody detects DCK protein by western blot analysis. A. 30 μg PC-12 whole cell extract B. 30 μg Rat2 whole cell extract 12 % SDS-PAGE DCK antibody , dilution: 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Mouse Un-conjugated FACS, WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB 100 μL Log in to see 7 to 9 Days
$507.83
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using DCK antibody. 100 μL Log in to see 16 Days
$334.02
Details
Human Rabbit Un-conjugated IF, IHC (p), IP, WB The anti-DCK Pab (ABIN391125) is used in Western blot to detect DCK in mouse intestine tissue lysate. Deoxycytidine kinase(DCK) immunoprecipitated from H460cells with 7.5ug (microgram) of the dCK antibody (ABIN391125) using the Pierce classic mammalian IP kit (#45217) reagent as described as manufacturer instructions (lane 1, 3) and Current Protocols in Cell Biology, 1998, 7.2.1-7.2.21. Proteins separated on a 12% SDS gel, transferred to a PVDF membrane and probed with 1:700 dilution of DCK antibody (ABIN391125). Bands were detected using enhanced chemiluminescence (SuperSignal West Pico Chemiluminescent Substrate Kit). No specific reagents were employed to remove IgG from immunoprecipitated sample. Data courtesy of Dr. Stacy Shord, University of Illinois, Chicago. 400 μL Log in to see 10 to 11 Days
$335.50
Details

DCK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DCK Antibodies

  1. Human Polyclonal DCK Primary Antibody for IF, IHC (p) - ABIN391125 : Hartford, Duan, Delaney, Mi, Kistner, Lamba, Huang, Dolan: Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. in Blood 2009 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal DCK Primary Antibody for IHC - ABIN965975 : Krawiec, Kierdaszuk, Shugar: Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal DCK Primary Antibody for ELISA, WB - ABIN514896 : Funel, Giovannetti, Del Chiaro, Mey, Pollina, Nannizzi, Boggi, Ricciardi, Del Tacca, Bevilacqua, Mosca, Danesi, Campani: Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma. in Laboratory investigation; a journal of technical methods and pathology 2008 (PubMed)

  4. Human Monoclonal DCK Primary Antibody for IF, ELISA - ABIN514902 : Costantino, Witkiewicz, Kuwano, Cozzitorto, Kennedy, Dasgupta, Keen, Yeo, Gorospe, Brody: The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. in Cancer research 2009 (PubMed)

  5. Cow (Bovine) Polyclonal DCK Primary Antibody for WB - ABIN2784622 : Iyidogan, Lutz: Systematic exploration of active site mutations on human deoxycytidine kinase substrate specificity. in Biochemistry 2008 (PubMed)
    Show all 2 Pubmed References

More Antibodies against DCK Interaction Partners

Human Deoxycytidine Kinase (DCK) interaction partners

  1. study suggests that DCK knockdown facilitates apoptosis while inhibiting proliferation and tumorigenicity in vivo of cervical cancer HeLa cells.

  2. Phosphorylated and activated DCK can inhibit radiation-induced cell death including apoptosis and mitotic catastrophe, and promote radiation-induced autophagy through PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway.

  3. Low deoxycytidine kinase expression is associated with periampullary adenocarcinoma.

  4. recently described a human deoxycytidine kinase mutant (G12 (show TCF3 Antibodies)) that sensitizes cancer cell lines to treatment with gemcitabine. Here, starting from the G12 (show TCF3 Antibodies) variant, we identified a mutant that triggers even greater sensitisation to gemcitabine than G12 (show TCF3 Antibodies).

  5. RNA expression of deoxycytidine kinase (DCK), human equilibrative nucleoside transporter-1 (ENT1 (show SLC29A1 Antibodies)) and ribonucleotide reductase M1 (RRM1 (show RRM1 Antibodies)) were significantly higher and cytidine deaminase (CDA (show CDA Antibodies)) was significantly lower in ex vivo Ara (show FOXC1 Antibodies)-C sensitive samples.

  6. n the multivariate Cox (show COX8A Antibodies) regression analysis, we found that age at diagnosis, wild-type genotype of the CDA (show CDA Antibodies) A79C polymorphism, and wild-type genotype of the dCK C360G polymorphism were the most significant prognostic factors for predicting the risk of death

  7. results strongly suggest that (1) the E197K alteration in DCK causes inactivation of DCK, and that (2) loss of the normal E197 allele is the crucial mechanism in acquisition of gemcitabine resistance in the RMKN28 tumor cell line

  8. DCK rs12648166 and DCK rs4694362 SNPs were associated with hematologic toxicity (OR = 2.63, CI 95% = 1.37-5.04, P = 0.0036 and OR = 2.53, CI 95% = 1.34-4.80, P = 0.0044, respectively).

  9. These findings indicate that the decitabine metabolic pathway affects its therapeutic effects, lower hENT1 expression may induce primary resistance and down-regulated DCK expression may be related to secondary resistance.

  10. DCK expression levels are prognostic and had predictive value for sensitivity to 5-FU in pancreatic cancer.

Mouse (Murine) Deoxycytidine Kinase (DCK) interaction partners

  1. Mutation of a single serine 74 residue has profound effects on murine T and B lymphocyte (show AKAP17A Antibodies) development, suggesting that post-translational regulation of dCK has a role in maintaining genomic stability during hematopoiesis.

  2. activating the dAdo-DCK-dATP pathway directly results in increased apoptosis in the lungs of mice with air-space enlargement and suggests a novel therapeutic target for the treatment of COPD (show ARCN1 Antibodies)

  3. Deoxycytidine kinase is a new regulator of hematopoietic integrity and lymphocyte quiescence and survival.

  4. The severe impact of dCK inactivation on lymphopoiesis was unexpected given that nucleoside salvage has been thought to play a limited, "fine-tuning" role in regulating deoxyribonucleotide triphosphate pools produced by the de novo pathway.

DCK Antigen Profile

Protein Summary

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.

Gene names and symbols associated with DCK

  • deoxycytidine kinase (DCK) antibody
  • deoxycytidine kinase (dck) antibody
  • deoxycytidine kinase, gene 2 L homeolog (dck.2.L) antibody
  • deoxycytidine kinase, gene 2 (dck.2) antibody
  • deoxycytidine kinase (Dck) antibody
  • Deoxycytidine kinase (FPV059) antibody
  • Deoxycytidine kinase (FPV151) antibody
  • deoxycytidine kinase, gene 1 L homeolog (dck.1.L) antibody
  • DCK antibody
  • dck1 antibody
  • wu:fc15f06 antibody
  • zgc:101771 antibody

Protein level used designations for DCK

deoxynucleoside kinase , Deoxycytidine kinase , deoxycytidine kinase , deoxycytidine kinase 1 , deoxyribonucleoside kinase

GENE ID SPECIES
1633 Homo sapiens
100196160 Salmo salar
446773 Xenopus laevis
549546 Xenopus (Silurana) tropicalis
100305233 Oncorhynchus mykiss
461273 Pan troglodytes
705040 Macaca mulatta
482188 Canis lupus familiaris
422648 Gallus gallus
79127 Rattus norvegicus
474325 Danio rerio
530642 Bos taurus
13178 Mus musculus
1486607 Fowlpox virus
1486699 Fowlpox virus
496391 Xenopus laevis
100713916 Cavia porcellus
101683216 Mustela putorius furo
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