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DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Additionally we are shipping DEF6 Antibodies (78) and and many more products for this protein.
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Swap70b and Def6a delineate Wnt11 and Wnt5b signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
def6 morphants phenocopy Wnt5b mutants and ectopic overexpression of def6 essentially rescues Wnt5b morphants, indicating a novel role for def6 as a central GEF downstream of Wnt5b signaling
this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions
DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival.
IBP was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases
DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.
Molecular cloning of IBP, a guanine nucleotide exchange factor, which is highly expressed in the immune system.
IBP is a novel guanine nucleotide exchange factor and is recruited to the immunological synapse by T cell receptor engagement
DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function
level of expression correlates with the degree of malignancy in breast carcinoma tissues
Overexpression of the Interferon regulatory factor 4-binding protein is associated with Colorectal Carcinoma.
DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003
differentially expressed in FDCP 6 homolog (mouse)
, differentially expressed in FDCP 6 homolog
, IRF-4-binding protein
, IRF4-binding protein
, SWAP-70-like adapter of T-cells
, SWAP-70-like adaptor protein of T cells