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Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity).. Additionally we are shipping Digestive Organ Expansion Factor Homolog (Zebrafish) Antibodies (11) and many more products for this protein.
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DEF is highly expressed in human neuroblastoma (show ARHGEF16 Proteins), and its depletion in human neuroblastoma (show ARHGEF16 Proteins) cell lines induces apoptosis.
Colonic tissue from patients with Hirschsprung's disease showed lower expression levels of digestive-organ expansion factor (DIEXF).
characterization of the related zebrafish protein
Def can mediate the degradation of p53 (show TP53 Proteins) protein and that this process is independent of the proteasome pathway, but dependent on the activity of Calpain3, a cysteine protease (show CASP8 Proteins).
def gene encodes a novel pan-endoderm-specific factor.p53 is tightly regulated by factor Def, especially during organogenesis
Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity).
digestive organ expansion factor homolog
, digestive-organ expansion factor homolog
, novel putative protein similar to YIL091C yeast hypothetical 84 kD protein from SGA1-KTR7
, digestive organ expansion factor
, digestive-organ expansion factor
, lily liver