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DHDH encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. Additionally we are shipping DHDH Antibodies (49) and DHDH Kits (7) and many more products for this protein.
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Some genetical studies show also altered expression of the dehydrogenases ALDH2 and DHDH genes in patients with Dupuytren's disease and with digestive tract malignancies related to alcohol abuse.(review)
Possible association of both variants of the DHDH gene with familial Dupuytren's disease, as over-representation of the rs2270941 and rs11666105 alterations was identified among 100 patients with a familial history.
Survival was significantly better in gastric cancer patients with low DDH expression.
Comparison of other mammalian homologs with the human enzyme shows that dimeric DDs constitute a novel protein family.
Site-directed mutagenesis of conserved residues shows that Tyr-180 plays a critical role in the catalytic function of this enzyme, while His-79 is required in the coenzyme binding and chemical steps of the reaction.
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction.
dimeric dihydrodiol dehydrogenase
, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
, dihydrodiol dehydrogenase (dimeric)
, 3-deoxyglucosone reductase
, D-xylose 1-dehydrogenase
, D-xylose-NADP dehydrogenase
, xylose dehydrogenase 1