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The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. Additionally we are shipping DAB1 Kits (22) and DAB1 Proteins (6) and many more products for this protein.
Showing 10 out of 150 products:
Human Polyclonal DAB1 Primary Antibody for IHC - ABIN965969
Chen, Ochalski, Tran, Sahir, Schubert, Pramatarova, Howell: Interaction between Dab1 and CrkII is promoted by Reelin signaling. in Journal of cell science 2004
Show all 3 Pubmed References
Human Polyclonal DAB1 Primary Antibody for ELISA, ICC - ABIN6256680
Liu, Li, Shu, Xiao, Feng: Ephrin‑b3 modulates hippocampal neurogenesis and the reelin signaling pathway in a pilocarpine‑induced model of epilepsy. in International journal of molecular medicine 2018
In intestine a truncated Dab1 variant transmits the reelin (show RELN Antibodies) signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location.
these results establish an unstable repeat insertion in DAB1 as a cause of cerebellar degeneration.
Study shows that early neural cells transiently express Reelin (show RELN Antibodies) at the time they leave the presumptive olfactory/vomeronasal epithelium and that Dab 1 is present in the migratory cell mass and in the presumptive ensheathing cells in the absence of reelin (show RELN Antibodies).
this study is the first to provide genetic evidence for DAB1 as a candidate AD liability/protection gene, although the strength of the contribution of DAB1 may differ among populations
results of this study demonstrated the presence of reelin (show RELN Antibodies), its receptors VLDLR (show VLDLR Antibodies) and ApoER2 (show LRP8 Antibodies) as well as Dab1 in the ENS and might indicate a novel role of the reelin (show RELN Antibodies) system in regulating neuronal plasticity and pre-synaptic functions in the ENS.
The finding of this study suggested that variations in DAB1 involved in the Reelin signaling pathway might contribute to genetic susceptibility to autism with Chinese Han decent.
Variation in genes encoding proteins at the gateway of Reelin (show RELN Antibodies) signaling: ligands RELN (show RELN Antibodies) and APOE (show APOE Antibodies), their common receptors APOER2 (show LRP8 Antibodies) and VLDLR (show VLDLR Antibodies), and adaptor DAB1, was examined.
show that Reelin (show RELN Antibodies)-stimulated Notch-1 (show NOTCH1 Antibodies) activation is dependent on Reelin (show RELN Antibodies) signaling
alternative splicing of Dab1 is conserved in avian and mammalian species, with Dab1-L driving SFK phosphorylation in both species
we report for the first time, that DAB1 is significantly up-regulated in human frontal cortex brain samples of Alzheimer disease patients
Deletion of Dab1 in endothelial cells leads to a reduced secretion of laminin-alpha4 and decreased activation of integrin-beta1 in glial cells, which in turn control neuronal migration and barrier properties of the neurovascular unit.
These observations suggest that the morphogenesis in these hippocampal formation subdivisions employs different developmental mechanisms involving Dab1 function.
These results suggest that deficiency of Reelin (show RELN Antibodies)-Dab1 signal in the dorsal forebrain is involved in the pathogenesis of some symptoms of human psychiatric disorders.
RBX2 (show RNF7 Antibodies), a core component of the E3 ubiquitin ligase (show MUL1 Antibodies) CRL5, is essential for retinal layering and function. RBX2 (show RNF7 Antibodies) regulates the final cell position of rod bipolar cells, cone photoreceptors and Muller glia. Our data indicate that sustained RELN (show RELN Antibodies)/DAB1 signaling, triggered by depletion of RBX2 (show RNF7 Antibodies) or SOCS7 (show SOCS7 Antibodies) - a CRL5 substrate adaptor known to recruit DAB1 - causes rod bipolar cell misposition.
Mice with low or no Dab1 expression exhibited reduced calling rates, altered call-type usage, and differential vocal development trajectories.
Results showed that the Dab1 nuclear localization signal mutant can translocate into the nucleus via an unconventional temperature-dependent/ATP-dependent and cytoplasmic soluble factor-independent/RanGTP gradient-independent manner, suggesting that Dab1 has 2 (show HAS2 Antibodies) different nuclear translocation pathways; and that the regulation of subcellular localization of Dab1 is important for the proper migration of excitatory neurons.
This study showed that spontaneous Dab1 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
an aberrant fragment of Dab1 protein (p64 (show IL2RG Antibodies)/60) is present in the brain of yotari mouse
When pregnant mice are exposed to EMF, Dab1 expression increases in the EMF-treated fetal cerebral cortex extracts as compared to controls and SHAM group.
Alternative spliced forms of disabled homolog 1 (DAB1) have been isolated from brain and liver.
Alternatively spliced dab1 isoforms were identified.
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
disabled homolog 1
, disabled homolog 1 (Drosophila)
, DAB1 variant protein-like
, disabled homolog 1-like
, disabled 1 type B
, disabled homolog 1b