anti-Disabled Homolog 1 (Drosophila) (DAB1) Antibodies

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. Additionally we are shipping DAB1 Kits (22) and DAB1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DAB1 1600 O75553
DAB1 13131 P97318
DAB1 266729 Q8CJH2
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Top anti-DAB1 Antibodies at antibodies-online.com

Showing 10 out of 151 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DAB1 Antibody Titration: 0.2-1 ug/mlPositive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of DAB1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of DAB1 expression in MCF7 (A), HEK293T (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HeLa cells, using Dab1 (Ab-220) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using Dab1 (Ab-220) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from LOVO cells, using Dab1 (Phospho-Tyr232) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HepG2/293 cells, using Dab1 (Ab-232) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of MCF7 cells, using Dab1 (Ab-232) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: DAB1 Antibody [NBP2-16095] - Sample: HepG2 cells were fixed in 4% paraformaldehyde at RT for 15 min.Green: DAB1 protein stained by DAB1 antibody [N1N3] diluted at 1:500. Blue: Hoechst 33342 staining. Immunohistochemistry-Paraffin: DAB1 Antibody [NBP2-16095] - Immunohistochemical analysis of paraffin-embedded hela xenograft, using antibody at 1:500 dilution. 0.1 mL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of DAB1 Antibody (Center) (ABIN652935) in mouse brain tissue lysates (35 µg/lane). DAB1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with DAB1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of Phospho-Dab1 (Tyr232) expression in various lysates ABIN6267246 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, IF, WB Western Blot (WB) analysis of specific cells using Dab1 Polyclonal Antibody. 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, IF, WB 100 μL Log in to see 16 Days
$181.73
Details

Top referenced anti-DAB1 Antibodies

  1. Human Polyclonal DAB1 Primary Antibody for IHC - ABIN965969 : Chen, Ochalski, Tran, Sahir, Schubert, Pramatarova, Howell: Interaction between Dab1 and CrkII is promoted by Reelin signaling. in Journal of cell science 2004 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal DAB1 Primary Antibody for ELISA, ICC - ABIN6256680 : Liu, Li, Shu, Xiao, Feng: Ephrin‑b3 modulates hippocampal neurogenesis and the reelin signaling pathway in a pilocarpine‑induced model of epilepsy. in International journal of molecular medicine 2018 (PubMed)

More Antibodies against DAB1 Interaction Partners

Human Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. In intestine a truncated Dab1 variant transmits the reelin signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location.

  2. these results establish an unstable repeat insertion in DAB1 as a cause of cerebellar degeneration.

  3. Study shows that early neural cells transiently express Reelin at the time they leave the presumptive olfactory/vomeronasal epithelium and that Dab 1 is present in the migratory cell mass and in the presumptive ensheathing cells in the absence of reelin.

  4. this study is the first to provide genetic evidence for DAB1 as a candidate AD liability/protection gene, although the strength of the contribution of DAB1 may differ among populations

  5. results of this study demonstrated the presence of reelin, its receptors VLDLR and ApoER2 as well as Dab1 in the ENS and might indicate a novel role of the reelin system in regulating neuronal plasticity and pre-synaptic functions in the ENS.

  6. The finding of this study suggested that variations in DAB1 involved in the Reelin signaling pathway might contribute to genetic susceptibility to autism with Chinese Han decent.

  7. Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined.

  8. show that Reelin-stimulated Notch-1 activation is dependent on Reelin signaling

  9. alternative splicing of Dab1 is conserved in avian and mammalian species, with Dab1-L driving SFK phosphorylation in both species

  10. we report for the first time, that DAB1 is significantly up-regulated in human frontal cortex brain samples of Alzheimer disease patients

  11. Dab1, an essential component of the reelin pathway, is required for glia-independent somal translocation in the neocortex.

  12. Fe65 and Dab1 compete for binding to APP. Dab1 significantly decreased the amount of APP bound to LRP and the level of secreted APP and APP-CTF in LRP expressing cells

  13. Thus, the present observations suggest a correlation between Dab1 phosphorylation, Abeta deposition and PrP(sc) type in sCJD.

  14. This gene, is an intracellular adaptor of the Reelin pathway and reveals unusual complexity in human and mouse.

  15. involvement of disabled homolog 1 in neurogenesis

  16. RELN and DAB1 coexpression in these neurons is necessary for both normal cortical development and mature function.

  17. Dab1 immunoreactivity is found in certain populations of amacrine cells of the retina, with lobular appendages in the outer half of the inner plexiform layer (IPL) and a bushy, smooth dendritic tree in the inner half of the IPL.

  18. significantly lower levels of disabled homolog 1 gene transcripts were detected in gangliogliomas compared to controls

  19. Dab1 regulates both cell surface expression and internalization of Reelin receptors

  20. phosphoinositide-binding region within Dab1 PTB domain is required for membrane localization and basal tyrosine phosphorylation of Dab1

Mouse (Murine) Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. Deletion of Dab1 in endothelial cells leads to a reduced secretion of laminin-alpha4 and decreased activation of integrin-beta1 in glial cells, which in turn control neuronal migration and barrier properties of the neurovascular unit.

  2. In intestine a truncated Dab1 variant transmits the reelin signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location.

  3. These observations suggest that the morphogenesis in these hippocampal formation subdivisions employs different developmental mechanisms involving Dab1 function.

  4. These results suggest that deficiency of Reelin-Dab1 signal in the dorsal forebrain is involved in the pathogenesis of some symptoms of human psychiatric disorders.

  5. RBX2, a core component of the E3 ubiquitin ligase CRL5, is essential for retinal layering and function. RBX2 regulates the final cell position of rod bipolar cells, cone photoreceptors and Muller glia. Our data indicate that sustained RELN/DAB1 signaling, triggered by depletion of RBX2 or SOCS7 - a CRL5 substrate adaptor known to recruit DAB1 - causes rod bipolar cell misposition.

  6. Mice with low or no Dab1 expression exhibited reduced calling rates, altered call-type usage, and differential vocal development trajectories.

  7. Results showed that the Dab1 nuclear localization signal mutant can translocate into the nucleus via an unconventional temperature-dependent/ATP-dependent and cytoplasmic soluble factor-independent/RanGTP gradient-independent manner, suggesting that Dab1 has 2 different nuclear translocation pathways; and that the regulation of subcellular localization of Dab1 is important for the proper migration of excitatory neurons.

  8. This study showed that spontaneous Dab1 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.

  9. an aberrant fragment of Dab1 protein (p64/60) is present in the brain of yotari mouse

  10. When pregnant mice are exposed to EMF, Dab1 expression increases in the EMF-treated fetal cerebral cortex extracts as compared to controls and SHAM group.

  11. It findings link reelin with Dab1 and suggest that Dab1 functions downstream of reelin action on the homeostasis of the crypt-villus unit.

  12. The results of this study indicate a causal relation between the downregulation of Dab1 protein levels during development and the structural and behavioral deficits associated with psychiatric diseases in the adult.

  13. The expression of Dab-1 was analyzed in the developing mouse autopod. Transcripts of Dab-1 were abundant in the autopodial tendon primordia, but transcripts were also present in the undifferentiated mesoderm located around the digits.

  14. results suggest a major role of VEGF in the regulation of reelin signaling, and Dab1 as a key molecule in the cross talk between reelin and VEGF signaling pathways.

  15. Dab1 is specifically knocked out in immature neurons while it remains active in glial cells.

  16. Dab1 mediated the association of CIN85 with ApoER2 or VLDLR in neurons.

  17. Dab1 is a critical regulator of synaptic function and hippocampal-dependent associative and spatial learning.

  18. These results indicate a crucial participation of the basal ganglia in the functional phenotype of ataxic Dab1(scm) mutants.

  19. Reeler and scrambler (Dab1) mutant neurites extend tangentially rather than radially, and the Golgi apparatus that normally invests the apical neurite is compact in both reeler and scrambler mutants.

Pig (Porcine) Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. Alternative spliced forms of disabled homolog 1 (DAB1) have been isolated from brain and liver.

Zebrafish Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. RT-PCR analysis also reveals that both drDab1 genes show distinct developmental-specific expression patterns throughout development.

  2. Alternatively spliced dab1 isoforms were identified.

DAB1 Antigen Profile

Protein Summary

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Gene names and symbols associated with DAB1

  • DAB1, reelin adaptor protein (DAB1) antibody
  • disabled 1 (Dab1) antibody
  • DAB1, reelin adaptor protein (Dab1) antibody
  • disabled homolog 1 (LOC100232823) antibody
  • Dab, reelin signal transducer, homolog 1a (Drosophila) (dab1a) antibody
  • Dab, reelin signal transducer, homolog 1b (Drosophila) (dab1b) antibody
  • AI956902 antibody
  • C630028C02Rik antibody
  • DAB1 antibody
  • disabled-1 antibody
  • LOC100232823 antibody
  • scm antibody
  • scr antibody
  • scrambler antibody
  • si:dkey-242m13.1 antibody
  • yot antibody
  • zgc:136547 antibody

Protein level used designations for DAB1

disabled homolog 1 , yotari , disabled1 , disabled homolog 1 (Drosophila) , DAB1 variant protein-like , disabled homolog 1-like , disabled 1 type B , disabled homolog 1b

GENE ID SPECIES
1600 Homo sapiens
13131 Mus musculus
266729 Rattus norvegicus
374083 Gallus gallus
100037307 Sus scrofa
100232823 Taeniopygia guttata
538818 Bos taurus
610344 Canis lupus familiaris
692351 Danio rerio
740508 Pan troglodytes
100337993 Oryctolagus cuniculus
100453388 Pongo abelii
100583389 Nomascus leucogenys
100049825 Equus caballus
100729327 Cavia porcellus
678641 Danio rerio
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