Disabled Homolog 1 (Drosophila) Proteins (DAB1)

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. Additionally we are shipping DAB1 Antibodies (152) and DAB1 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DAB1 1600 O75553
DAB1 266729 Q8CJH2
DAB1 13131 P97318
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Top DAB1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Rat T7 tag,His tag 100 μg Log in to see 15 to 18 Days

DAB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus) ,
Mouse (Murine)

More Proteins for Disabled Homolog 1 (Drosophila) (DAB1) Interaction Partners

Zebrafish Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. Alternatively spliced dab1 isoforms were identified.

Human Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. these results establish an unstable repeat insertion in DAB1 as a cause of cerebellar degeneration.

  2. Study shows that early neural cells transiently express Reelin (show RELN Proteins) at the time they leave the presumptive olfactory/vomeronasal epithelium and that Dab 1 is present in the migratory cell mass and in the presumptive ensheathing cells in the absence of reelin (show RELN Proteins).

  3. this study is the first to provide genetic evidence for DAB1 as a candidate AD liability/protection gene, although the strength of the contribution of DAB1 may differ among populations

  4. results of this study demonstrated the presence of reelin (show RELN Proteins), its receptors VLDLR (show VLDLR Proteins) and ApoER2 (show LRP8 Proteins) as well as Dab1 in the ENS and might indicate a novel role of the reelin (show RELN Proteins) system in regulating neuronal plasticity and pre-synaptic functions in the ENS.

  5. The finding of this study suggested that variations in DAB1 involved in the Reelin signaling pathway might contribute to genetic susceptibility to autism with Chinese Han decent.

  6. Variation in genes encoding proteins at the gateway of Reelin (show RELN Proteins) signaling: ligands RELN (show RELN Proteins) and APOE (show APOE Proteins), their common receptors APOER2 (show LRP8 Proteins) and VLDLR (show VLDLR Proteins), and adaptor DAB1, was examined.

  7. show that Reelin (show RELN Proteins)-stimulated Notch-1 (show NOTCH1 Proteins) activation is dependent on Reelin (show RELN Proteins) signaling

  8. alternative splicing of Dab1 is conserved in avian and mammalian species, with Dab1-L driving SFK phosphorylation in both species

  9. we report for the first time, that DAB1 is significantly up-regulated in human frontal cortex brain samples of Alzheimer disease patients

  10. Dab1, an essential component of the reelin (show RELN Proteins) pathway, is required for glia-independent somal translocation in the neocortex.

Mouse (Murine) Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. These observations suggest that the morphogenesis in these hippocampal formation subdivisions employs different developmental mechanisms involving Dab1 function.

  2. These results suggest that deficiency of Reelin (show RELN Proteins)-Dab1 signal in the dorsal forebrain is involved in the pathogenesis of some symptoms of human psychiatric disorders.

  3. RBX2 (show RNF7 Proteins), a core component of the E3 ubiquitin ligase (show MUL1 Proteins) CRL5, is essential for retinal layering and function. RBX2 (show RNF7 Proteins) regulates the final cell position of rod bipolar cells, cone photoreceptors and Muller glia. Our data indicate that sustained RELN (show RELN Proteins)/DAB1 signaling, triggered by depletion of RBX2 (show RNF7 Proteins) or SOCS7 - a CRL5 substrate adaptor known to recruit DAB1 - causes rod bipolar cell misposition.

  4. Mice with low or no Dab1 expression exhibited reduced calling rates, altered call-type usage, and differential vocal development trajectories.

  5. Results showed that the Dab1 nuclear localization signal mutant can translocate into the nucleus via an unconventional temperature-dependent/ATP-dependent and cytoplasmic soluble factor-independent/RanGTP gradient-independent manner, suggesting that Dab1 has 2 (show HAS2 Proteins) different nuclear translocation pathways; and that the regulation of subcellular localization of Dab1 is important for the proper migration of excitatory neurons.

  6. This study showed that spontaneous Dab1 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.

  7. an aberrant fragment of Dab1 protein (p64 (show IL2RG Proteins)/60) is present in the brain of yotari mouse

  8. When pregnant mice are exposed to EMF, Dab1 expression increases in the EMF-treated fetal cerebral cortex extracts as compared to controls and SHAM group.

  9. It findings link reelin (show RELN Proteins) with Dab1 and suggest that Dab1 functions downstream of reelin (show RELN Proteins) action on the homeostasis of the crypt-villus unit.

  10. The results of this study indicate a causal relation between the downregulation of Dab1 protein levels during development and the structural and behavioral deficits associated with psychiatric diseases in the adult.

Pig (Porcine) Disabled Homolog 1 (Drosophila) (DAB1) interaction partners

  1. Alternative spliced forms of disabled homolog 1 (DAB1) have been isolated from brain and liver.

DAB1 Protein Profile

Protein Summary

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Gene names and symbols associated with DAB1

  • DAB1, reelin adaptor protein (DAB1)
  • disabled homolog 1 (LOC100232823)
  • Dab, reelin signal transducer, homolog 1a (Drosophila) (dab1a)
  • DAB1, reelin adaptor protein (Dab1)
  • disabled 1 (Dab1)
  • AI956902 protein
  • C630028C02Rik protein
  • DAB1 protein
  • disabled-1 protein
  • LOC100232823 protein
  • scm protein
  • scr protein
  • scrambler protein
  • si:dkey-242m13.1 protein
  • yot protein

Protein level used designations for DAB1

disabled homolog 1 , disabled1 , disabled homolog 1 (Drosophila) , DAB1 variant protein-like , disabled homolog 1-like , yotari

100049825 Equus caballus
100232823 Taeniopygia guttata
692351 Danio rerio
740508 Pan troglodytes
100337993 Oryctolagus cuniculus
100453388 Pongo abelii
100583389 Nomascus leucogenys
1600 Homo sapiens
266729 Rattus norvegicus
538818 Bos taurus
13131 Mus musculus
374083 Gallus gallus
610344 Canis lupus familiaris
100037307 Sus scrofa
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