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The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. Additionally we are shipping DAB1 Antibodies (140) and DAB1 Kits (23) and many more products for this protein.
Showing 6 out of 6 products:
Alternatively spliced dab1 isoforms were identified.
these results establish an unstable repeat insertion in DAB1 as a cause of cerebellar degeneration.
Study shows that early neural cells transiently express Reelin (show RELN Proteins) at the time they leave the presumptive olfactory/vomeronasal epithelium and that Dab 1 is present in the migratory cell mass and in the presumptive ensheathing cells in the absence of reelin (show RELN Proteins).
this study is the first to provide genetic evidence for DAB1 as a candidate AD liability/protection gene, although the strength of the contribution of DAB1 may differ among populations
results of this study demonstrated the presence of reelin (show RELN Proteins), its receptors VLDLR (show VLDLR Proteins) and ApoER2 (show LRP8 Proteins) as well as Dab1 in the ENS and might indicate a novel role of the reelin (show RELN Proteins) system in regulating neuronal plasticity and pre-synaptic functions in the ENS.
The finding of this study suggested that variations in DAB1 involved in the Reelin signaling pathway might contribute to genetic susceptibility to autism with Chinese Han decent.
Variation in genes encoding proteins at the gateway of Reelin (show RELN Proteins) signaling: ligands RELN (show RELN Proteins) and APOE (show APOE Proteins), their common receptors APOER2 (show LRP8 Proteins) and VLDLR (show VLDLR Proteins), and adaptor DAB1, was examined.
show that Reelin (show RELN Proteins)-stimulated Notch-1 (show NOTCH1 Proteins) activation is dependent on Reelin (show RELN Proteins) signaling
alternative splicing of Dab1 is conserved in avian and mammalian species, with Dab1-L driving SFK phosphorylation in both species
we report for the first time, that DAB1 is significantly up-regulated in human frontal cortex brain samples of Alzheimer disease patients
Dab1, an essential component of the reelin (show RELN Proteins) pathway, is required for glia-independent somal translocation in the neocortex.
Results showed that the Dab1 nuclear localization signal mutant can translocate into the nucleus via an unconventional temperature-dependent/ATP-dependent and cytoplasmic soluble factor-independent/RanGTP gradient-independent manner, suggesting that Dab1 has 2 (show HAS2 Proteins) different nuclear translocation pathways; and that the regulation of subcellular localization of Dab1 is important for the proper migration of excitatory neurons.
This study showed that spontaneous Dab1 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
an aberrant fragment of Dab1 protein (p64 (show IL2RG Proteins)/60) is present in the brain of yotari mouse
When pregnant mice are exposed to EMF, Dab1 expression increases in the EMF-treated fetal cerebral cortex extracts as compared to controls and SHAM group.
It findings link reelin (show RELN Proteins) with Dab1 and suggest that Dab1 functions downstream of reelin (show RELN Proteins) action on the homeostasis of the crypt-villus unit.
The results of this study indicate a causal relation between the downregulation of Dab1 protein levels during development and the structural and behavioral deficits associated with psychiatric diseases in the adult.
The expression of Dab-1 was analyzed in the developing mouse autopod. Transcripts of Dab-1 were abundant in the autopodial tendon primordia, but transcripts were also present in the undifferentiated mesoderm located around the digits.
results suggest a major role of VEGF in the regulation of reelin signaling, and Dab1 as a key molecule in the cross talk between reelin and VEGF signaling pathways.
Dab1 is specifically knocked out in immature neurons while it remains active in glial cells.
Dab1 mediated the association of CIN85 (show SH3KBP1 Proteins) with ApoER2 (show LRP8 Proteins) or VLDLR (show VLDLR Proteins) in neurons.
Alternative spliced forms of disabled homolog 1 (DAB1) have been isolated from brain and liver.
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
disabled homolog 1
, disabled homolog 1 (Drosophila)
, DAB1 variant protein-like
, disabled homolog 1-like