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DLG3 encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction.
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This family broadens the mutational and phenotypical spectrum of DLG3-associated non-syndromic X-linked intellectual disability and demonstrates that heterozygous female mutation carriers can be as severely affected as males.
Following the critical period NMDA receptor function was unaffected by loss of SAP102 but there was a reduction in the divergence of TC connectivity. These data suggest that changes in synaptic function early in development caused by mutations in SAP102 result in changes in network connectivity later in life.
Insertion of a guanine into the DLG3 5' UTR (show UTS2R ELISA Kits), 7 bp upstream of the start codon, down regulated DLG3 protein levels. This non-coding variant segregates with X-linked intellectual disability in a large family.
Trans-homophilic interaction of CADM1 (show CADM1 ELISA Kits) activates PI3K (show PIK3CA ELISA Kits) by forming a complex with MAGuK-family proteins MPP3 (show MPP3 ELISA Kits) and Dlg (show DLG4 ELISA Kits).
miR (show MLXIP ELISA Kits)-1246 might play a role in neurological pathogenesis of human enterovirus 71 by regulating DLG3 gene in infected cells.
These data shed new light on the role of SAP102 in the regulation of NMDAR (show GRIN1 ELISA Kits) trafficking.
This study identified DLG3 significantly associated loci with a biologically plausible role in schizophrenia.
The data of this study suggested that DLG3 is down-regulated in this cancer type.
The PDZ-independent interaction between SAP102 and GluN2B (show GRIN2B ELISA Kits) mediates the synaptic clearance of GluN2B (show GRIN2B ELISA Kits)-containing NMDARs.(SAP102 protein)
Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin (show NBEA ELISA Kits).
our current study identified a functional interplay between PSD-95 (show DLG4 ELISA Kits) and synapse-associated protein 102 (SAP102) to regulate synaptic AMPA (show GRIA3 ELISA Kits) receptors
SAP102 has a fundamental role in trafficking the NMDA receptor complex to the synaptic sites.
The Dlg3 have functions in complex cognitive processes.
Dlg3 exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 through its PPxY motifs. These interactions are required for Dlg3 monoubiquitination, apical membrane recruitment, and tight junction consolidation.
Membrane-associated guanylate kinase (show GUK1 ELISA Kits) homolog SAP102 is a central organizers of the postsynaptic density at excitatory synapses on pyramidal neurons.
SAP102 interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. nteractions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons.
SAP102 was required for normal spatial learning. Loss of SAP102 results in changes in spatial strategy usage. Altered long term potentiation and spike-timing-dependent plasticity in SAP102 mutants. Couples NMDA receptors to MAPK/ERK (show MAPK1 ELISA Kits) pathway.
Results describe E-dlg (show DLG4 ELISA Kits), a mouse homologue of the Drosophila discs large (show DLG4 ELISA Kits) tumor suppressor (Dlg (show DLG4 ELISA Kits), also known as SAP97), that binds preferentially to SAP102.
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described.
disks large homolog 3
, synapse-associated protein 102
, discs large homolog 3
, discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
, PSD-95/SAP90-related protein 1