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DOK proteins are enzymatically inert adaptor or scaffolding proteins.
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the current study have explored in more detail the structure and function of the Dok-4 PTB (show PTBP1 Proteins) domain.
DOK4 expression in human T cells has been demonstrated, and its genomic structure has been predicted.
IRS5/DOK4 and IRS6/DOK5 (show DOK5 Proteins) represent two new signaling proteins with potential roles in insulin (show INS Proteins) and IGF-1 (show IGF1 Proteins) action
Results suggest that Dok-4, through activation of the Rap1-ERK1/2 pathway, regulates GDNF-mediated neurite outgrowth during neuronal development.
IRS-5 (DOK4) is significantly upregulated in 90% of examined clear cell RCCs. Studies on this gene has shown that it is regulated through chromatin remodeling in kidney cells
Epigenetic regulation of DOK4 expression is associated with non-small-cell lung cancer.
Dok-4 represents a novel negative regulator of T cells
Dok-4 can target Elk-4 (show ELK4 Proteins) activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization.
Dok-4 is a constitutively membrane-localized adapter molecule that may function as an inhibitor of tyrosine kinase (show TYRO3 Proteins) signaling in epithelial cells.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
, downstream of tyrosine kinase 4
, insulin receptor substrate 5
, docking protein 4