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Activates the Jnk signaling pathway. Additionally we are shipping DUSP22 Antibodies (95) and and many more products for this protein.
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JKAP/DUSP22 is downregulated in T cells of systemic lupus erythematosus nephritis
Data show that dual specificity phosphatase 22 (DUSP22) functions as a tumor suppressor gene in peripheral T-cell lymphomas (PTCL).
findings connect NOTCH1, DUSP22, and CCL19-driven chemotaxis within a single functional network, suggesting that modulation of the homing process may provide a relevant contribution to the unfavorable prognosis associated with NOTCH1 mutations in CLL.
findings suggest that CCR8 expression in ALCL is more closely related to the presence of DUSP22 rearrangements than to cutaneous involvement and that the function of CCR8 may extend beyond its skin-homing properties in this disease
Studies suggest that the presence of dual specificity phosphatase 22 (DUSP22) and p63 tumor suppressor protein (TP63) rearrangements might be useful to support a diagnosis of anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL).
Report morphologic features of ALK-negative anaplastic large cell lymphomas with DUSP22 gene rearrangements.
Reduced DUSP22 expression was found in colorectal cancer specimens. Low expression level of DUSP22 in stage IV patients had a poor survival outcome
The structure illuminates the molecular basis for substrate binding and may also facilitate the structure-assisted development of DUSP22 inhibitors.
study identified presence of promoter hypermethylation of the DUSP22 gene in Alzheimer's disease(AD); DUSP22 is a likely candidate gene for involvement in the pathogenesis of AD since it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling
Biallelic rearrangements of DUSP22 is found in CD30-positive T-cell lymphoproliferative disorders.
Firefighters had a higher prevalence of dual specificity phosphatase 22-promoter hypomethylation in blood DNA (P = 0.03) and the extent of hypomethylation correlated with duration of firefighting service (P = 0.04) but not with age.
Data show that t(6;7)(p25.3;q32.3) was associated with down-regulation of DUSP22 and up-regulation of MIR29 microRNAs on 7q32.3.
a new role for JKAP in the modulation of FAK phosphorylation and cell motility.
The crystal structre showed 1 domain with 6 alpha helices & 5 beta strans, a PTP-loop at the active site binding MES, and an Ala instead of a Trp at the substrate-stacking loop.
DUSP22 acts as a negative regulator of the estrogen receptor alpha-mediated signaling pathway in breast cancer cells.
Dusp22 expression in the adult mouse tissues and organs
cloning and characterization of JKAP, a positive regulator of the JNK pathway
DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway.
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity).
dual specificity phosphatase 22
, dual specificity protein phosphatase 22-A
, dual specificity protein phosphatase 22
, dual specificity phosphatase 22 like
, dual specificity protein phosphatase 22-B
, JNK-stimulating phosphatase 1
, JNK-stimulatory phosphatase-1
, MAP kinase phosphatase x
, homolog of mouse dual specificity phosphatase LMW-DSP2
, low molecular weight dual specificity phosphatase 2
, mitogen-activated protein kinase phosphatase x