anti-Duffy Blood Group, Chemokine Receptor (DARC) Antibodies

The protein encoded by DARC is a glycosylated membrane protein and a non-specific receptor for several chemokines. Additionally we are shipping DARC Proteins (8) and DARC Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DARC 2532 Q16570
DARC 689105  
DARC 13349 Q9QUI6
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Top anti-DARC Antibodies at antibodies-online.com

Showing 10 out of 140 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, FACS, IHC, IHC (p), WB ABIN250822 (0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. ABIN250822 (3?g/ml) staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185480 (0.1µg/ml) staining of human liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185480 (3µg/ml) staining of paraffin embedded human kidney. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Immunohistochemistry-Paraffin: DARC Antibody [NBP1-77278] - Mouse brain tissue with DARC antibody at 2.5 ug/ml. Western Blot: DARC Antibody [NBP1-77278] - Analysis in human cerebellum tissue lysate with antibody at 1 ug/mL. 0.1 mg Log in to see 8 to 11 Days
$485.88
Details
Human Rabbit Un-conjugated IC, IF, WB Western blot analysis of CD234 expression in HeLa (A), K562 (B), Raw264.7 (C), PC12 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of A549 cells, using CD234 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of DARC transfected lysate using anti-DARC MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with DARC MaxPab mouse polyclonal antibody (B02) . Western Blot analysis of DARC expression in transfected 293T cell line by DARC MaxPab polyclonal antibody.<br><br>Lane 1: DARC transfected lysate(35.60 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μL Log in to see 11 to 12 Days
$425.71
Details
Human Mouse PE FACS Detection of DARC in Human Red Blood Cells by Flow Cytometry. Human red blood cells were stained with Mouse Anti-Human DARC PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$363.40
Details
Mouse Sheep PE FACS Detection of DARC in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse TER-119 APC-conjugated Monoclonal Antibody. Detection of DARC in HEK293 Human Cell Line Transfected with Mouse DARC and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with mouse DARC and eGFP was stained with and either (A) Sheep Anti-Mouse/Rat DARC PE-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$399.05
Details
Human Mouse Fluorescein FACS Detection of DARC in Human Erythrocytes by Flow Cytometry. Human erythrocytes were stained with Mouse Anti-Human DARC Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$299.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$390.50
Details

DARC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DARC Antibodies

  1. Human Polyclonal DARC Primary Antibody for ELISA, FACS - ABIN250822 : Zeng, Ou, Yu, Feng, Yin, Li, Shen, Shao: Coexpression of atypical chemokine binders (ACBs) in breast cancer predicts better outcomes. in Breast cancer research and treatment 2011 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal DARC Primary Antibody for WB - ABIN1881251 : Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: Dengue hemorrhagic fever is associated with polymorphisms in JAK1. in European journal of human genetics : EJHG 2010 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal DARC Primary Antibody for ELISA, IHC - ABIN4304289 : Gardner, Patterson, Ashton, Stone, Middleton: The human Duffy antigen binds selected inflammatory but not homeostatic chemokines. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal DARC Primary Antibody for IHC, ELISA - ABIN1002190 : Chaudhuri, Polyakova, Zbrzezna, Williams, Gulati, Pogo: Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal DARC Primary Antibody for IHC (p), WB - ABIN2479380 : Murthy, Saxena: Investigations on sarcolemmal ATPase activities in ventricular tissues of swimming trained & sedentary rats. in Indian journal of experimental biology 1979 (PubMed)
    Show all 3 Pubmed References

  6. Mouse (Murine) Polyclonal DARC Primary Antibody for FACS - ABIN4897017 : Duchene, Novitzky-Basso, Thiriot, Casanova-Acebes, Bianchini, Etheridge, Hub, Nitz, Artinger, Eller, Caamaño, Rülicke, Moss, Megens, von Andrian, Hidalgo, Weber, Rot: Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. in Nature immunology 2017 (PubMed)

  7. Human Monoclonal DARC Primary Antibody for FACS - ABIN4895389 : Huang, Shah, Wang, Ye, Dowey, Tsang, Mendelsohn, Kato, Kickler, Cheng: Extensive ex vivo expansion of functional human erythroid precursors established from umbilical cord blood cells by defined factors. in Molecular therapy : the journal of the American Society of Gene Therapy 2014 (PubMed)

More Antibodies against DARC Interaction Partners

Human Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. DARC expression in cancer cells inhibits pancreatic ductal adenocarcinoma progression by suppressing STAT3 (show STAT3 Antibodies) activation through the inhibition of CXCR2 (show CXCR2 Antibodies) signaling

  2. The data suggest that selective exposure of the Duffy binding protein (DBP (show GC Antibodies)) binding site within DARC is key to the preferential binding of DBP (show GC Antibodies) to immature reticulocytes, which is the potential mechanism underlying the preferential infection of a reticulocyte subset by P vivax.

  3. population genetic analysis of DARC shows its association with malaria resistance

  4. We showed that DARC expression is down-regulated in CRC (show CALR Antibodies) and associated with clinical pathological features and MVD (show MVD Antibodies) of CRC (show CALR Antibodies). DARC might be involved in tumorigenesis, progression, angiogenesis, and metastasis of CRC (show CALR Antibodies).

  5. DARC is required for Staphylococcus aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis.

  6. study demonstrates the association of SNP rs12075 from DARC gene with the levels of serum IL8 (show IL8 Antibodies)

  7. DARC levels are elevated in human keloid fibroblasts and might inhibit the secretion of CCL2 (show CCL2 Antibodies).

  8. Through molecular genotyping we also identified polymorphisms in RhCE (show RHCE Antibodies), Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.

  9. Duffy blood group

  10. Isothermal titration calorimetry studies show these structures are part of a multi-step binding pathway, and individual point mutations of residues contacting DARC result in a complete loss of RBC (show CACNA1C Antibodies) binding by DBP (show GC Antibodies)-RII.

Mouse (Murine) Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. DARC was exquisitely restricted to post-capillary and small collecting venules and completely absent from arteries, arterioles, capillaries, veins, and most lymphatics in every tissue analyzed. Intravital microscopy showed that adhesive leukocyte-endothelial interactions were restricted to DARC(+) venules. DARC was detectable over the entire circumference of V-ECs, but was more concentrated at cell-cell junctions.

  2. DARC regulates recruitment of osteoclast precursors at the inflammation site

  3. The DARC/CD234 is expressed on macrophages and stabilizes CD82 (show CD82 Antibodies) on long-term repopulating hematopoietic stem cells, promoting their quiescence.

  4. Ackr1 deficiency appears to be protective in the ApoE (show APOE Antibodies) knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine (show CCL1 Antibodies) expression as well as T-cell subset frequency and inflammatory macrophage content.

  5. Darc plays a role in modulating the regulation of inflammatory response to bone injury and that lack of Darc expression promotes cartilage formation in fracture calluses but does not affect bony union or fracture healing at 21 days post-fracture.

  6. The data showed a role for erythrocyte DARC as a chemokine (show CCL1 Antibodies) reservoir and that endothelial DARC contributes to the pathogenesis of experimental autoimmune encephalomyelitis by shuttling chemokines across the blood-brain barrier.

  7. DARC is crucial for chemokine (show CCL1 Antibodies)-mediated leukocyte recruitment in vivo.

  8. Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion.

  9. Vascular endothelial cells may induce Duffy protein to regulate leukocytes and/or chemokine (show CCL1 Antibodies) trafficking

  10. role of the Duffy antigen and glycophorin A (show GYPA Antibodies) as receptors for rodent malaria parasite invasion of erythrocytes

Cow (Bovine) Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. the 5' flanking region of the DARC gene was isolated and characterized

DARC Antigen Profile

Protein Summary

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DARC

  • Duffy blood group, chemokine receptor (DARC) antibody
  • atypical chemokine receptor 1 (Duffy blood group) (ACKR1) antibody
  • atypical chemokine receptor 1 (Ackr1) antibody
  • atypical chemokine receptor 1 (Duffy blood group) (Ackr1) antibody
  • AA162249 antibody
  • Ackr1 antibody
  • CCBP1 antibody
  • CD234 antibody
  • DARC antibody
  • Dfy antibody
  • ESTM35 antibody
  • FY antibody
  • GPD antibody
  • GpFy antibody
  • WBCQ1 antibody

Protein level used designations for DARC

Duffy blood group, chemokine receptor , duffy antigen/chemokine receptor , Duffy antigen/chemokine receptor , Duffy blood group antigen , Fy glycoprotein , atypical chemokine receptor 1 , glycoprotein D , plasmodium vivax receptor , Duffy antigen receptor for chemokines , blood group antigen , duffy antigen/receptor for chemokine glycoprotein

GENE ID SPECIES
396618 Sus scrofa
478969 Canis lupus familiaris
100398804 Callithrix jacchus
100458473 Pongo abelii
100500770 Papio anubis
2532 Homo sapiens
689105 Rattus norvegicus
13349 Mus musculus
528076 Bos taurus
745985 Pan troglodytes
719284 Macaca mulatta
Selected quality suppliers for anti-DARC (DARC) Antibodies
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