anti-Duffy Blood Group, Chemokine Receptor (DARC) Antibodies

The protein encoded by DARC is a glycosylated membrane protein and a non-specific receptor for several chemokines. Additionally we are shipping DARC Proteins (9) and DARC Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DARC 2532 Q16570
DARC 689105  
DARC 13349 Q9QUI6
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Top anti-DARC Antibodies at antibodies-online.com

Showing 10 out of 135 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, FACS, IHC, WB ABIN185480 (0.1µg/ml) staining of human liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185480 (3µg/ml) staining of paraffin embedded human kidney. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, FACS, IHC, IHC (p), WB ABIN250822 (0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. ABIN250822 (3?g/ml) staining of paraffin embedded Human Kidney. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining. 0.1 mg Log in to see 7 to 9 Days
$488.73
Details
Human Rabbit Un-conjugated IC, IF, WB Western blot analysis of CD234 expression in HeLa (A), K562 (B), Raw264.7 (C), PC12 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of A549 cells, using CD234 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of DARC transfected lysate using anti-DARC MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with DARC MaxPab mouse polyclonal antibody (B02) . Western Blot analysis of DARC expression in transfected 293T cell line by DARC MaxPab polyclonal antibody.Lane 1: DARC transfected lysate(35.60 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 11 to 12 Days
$350.67
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Immunohistochemistry-Paraffin: DARC Antibody [NBP1-77278] - Mouse brain tissue with DARC antibody at 2.5 ug/ml. Western Blot: DARC Antibody [NBP1-77278] - Analysis in human cerebellum tissue lysate with antibody at 1 ug/mL. 0.1 mg Log in to see 8 to 11 Days
$488.73
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: DARC Antibody [NBP1-86586] - Staining of human bronchus shows capillary staining in stroma and membranous positivity in respiratory epithelial cells. Immunohistochemistry-Paraffin: DARC Antibody  - Staining of human smooth muscle shows high expression. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse PE FACS Detection of DARC in Human Red Blood Cells by Flow Cytometry. Human red blood cells were stained with Mouse Anti-Human DARC PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$363.86
Details
Mouse Sheep PE FACS Detection of DARC in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse TER-119 APC-conjugated Monoclonal Antibody. Detection of DARC in HEK293 Human Cell Line Transfected with Mouse DARC and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with mouse DARC and eGFP was stained with and either (A) Sheep Anti-Mouse/Rat DARC PE-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$396.63
Details
Human Mouse APC FACS Detection of DARC in Human Red Blood Cells by Flow Cytometry. Human red blood cells were stained with Mouse Anti-Human DARC APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$406.80
Details

Top referenced anti-DARC Antibodies

  1. Human Polyclonal DARC Primary Antibody for ELISA, FACS - ABIN250822 : Zeng, Ou, Yu, Feng, Yin, Li, Shen, Shao: Coexpression of atypical chemokine binders (ACBs) in breast cancer predicts better outcomes. in Breast cancer research and treatment 2011 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal DARC Primary Antibody for WB - ABIN1881251 : Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: Dengue hemorrhagic fever is associated with polymorphisms in JAK1. in European journal of human genetics : EJHG 2010 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal DARC Primary Antibody for ELISA, IHC - ABIN4304289 : Gardner, Patterson, Ashton, Stone, Middleton: The human Duffy antigen binds selected inflammatory but not homeostatic chemokines. in Biochemical and biophysical research communications 2004 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal DARC Primary Antibody for IHC, ELISA - ABIN1002191 : Chaudhuri, Polyakova, Zbrzezna, Williams, Gulati, Pogo: Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal DARC Primary Antibody for IHC (p), WB - ABIN2479380 : Murthy, Saxena: Investigations on sarcolemmal ATPase activities in ventricular tissues of swimming trained & sedentary rats. in Indian journal of experimental biology 1979 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal DARC Primary Antibody for FACS, IHC (p) - ABIN547525 : Brühl, Vielhauer, Weiss, Mack, Schlöndorff, Segerer: Expression of DARC, CXCR3 and CCR5 in giant cell arteritis. in Rheumatology (Oxford, England) 2005 (PubMed)

  7. Human Polyclonal DARC Primary Antibody for IHC (p), WB - ABIN541591 : Gil, Vita, Lebel-Binay, Miloux, Chalon, Kaghad, Marchiol-Fournigault, Conjeaud, Caput, Ferrara et al.: A member of the tetra spans transmembrane protein superfamily is recognized by a monoclonal antibody raised against an HLA class I-deficient, lymphokine-activated killer-susceptible, B lymphocyte ... in Journal of immunology (Baltimore, Md. : 1950) 1992 (PubMed)
    Show all 3 Pubmed References

More Antibodies against DARC Interaction Partners

Human Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. The mean number of rosettes formed by erythrocytes surrounding transfected mammalian COS-7 cells which expressed Plasmodium knowlesi Duffy binding protein differ between erythrocytes' Duffy antigen phenotypes. Plasmodium knowlesi Duffy binding protein displays higher binding to Fy(a+/b+) erythrocytes than to Fy(a+/b-) erythrocytes.

  2. The atypical chemokine receptor 1 polymorphism (rs12075) does not affect susceptibility to hepatitis C virus.

  3. The risk of Plasmodium vivax malaria associated with genetic variation of DARC in Thai patients is reported.

  4. Our findings in mice suggest that DARC alters the severity and resolution of AHR. These findings are complimented by our human analyses in which select DARC SNPs are associated with worse asthma control and symptoms.

  5. DARC expression in cancer cells inhibits pancreatic ductal adenocarcinoma progression by suppressing STAT3 activation through the inhibition of CXCR2 signaling

  6. This study reports 1-3 occurrences of P. vivax infection in each of 25 Duffy-negative children at six time points over two rainy seasons and the beginning of the third season.

  7. Data suggest that Type II congenital smell loss patients who exhibit both type I hyposmia and hypogeusia are genetically distinct from all other patients with Type II congenital smell loss. This distinction is based on decreased Fy(b) expression which correlated with abnormalities in two sensory modalities (hyposmia type I and hypogeusia).

  8. The data suggest that selective exposure of the Duffy binding protein (DBP) binding site within DARC is key to the preferential binding of DBP to immature reticulocytes, which is the potential mechanism underlying the preferential infection of a reticulocyte subset by P vivax.

  9. ACKR1 regulates neutrophil counts in blood. Lack of ACKR1 on nucleated erythroid cells together with its expression in endothelial cells causes neutropenia.

  10. population genetic analysis of DARC shows its association with malaria resistance

  11. Molecular identification of rare FY*Null and FY*X alleles in Caucasian thalassemic family from Sardinia.

  12. We showed that DARC expression is down-regulated in CRC and associated with clinical pathological features and MVD of CRC. DARC might be involved in tumorigenesis, progression, angiogenesis, and metastasis of CRC.

  13. DARC is required for Staphylococcus aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis.

  14. the odds for neutropenia in the ACKR1-null (FY-) individuals were 46-fold higher than for FY+ individuals (Crude odds ratio = 46, 95% confidence interval = 8.03-263, P < 0.001)

  15. study demonstrates the association of SNP rs12075 from DARC gene with the levels of serum IL8

  16. DARC levels are elevated in human keloid fibroblasts and might inhibit the secretion of CCL2.

  17. Through molecular genotyping we also identified polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.

  18. The majority of our population is heterozygous for Duffy antigens a and b.

  19. Duffy blood group

  20. Isothermal titration calorimetry studies show these structures are part of a multi-step binding pathway, and individual point mutations of residues contacting DARC result in a complete loss of RBC binding by DBP-RII.

Mouse (Murine) Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. Our findings in mice suggest that DARC alters the severity and resolution of AHR. These findings are complimented by our human analyses in which select DARC SNPs are associated with worse asthma control and symptoms.

  2. DARC was exquisitely restricted to post-capillary and small collecting venules and completely absent from arteries, arterioles, capillaries, veins, and most lymphatics in every tissue analyzed. Intravital microscopy showed that adhesive leukocyte-endothelial interactions were restricted to DARC(+) venules. DARC was detectable over the entire circumference of V-ECs, but was more concentrated at cell-cell junctions.

  3. DARC regulates recruitment of osteoclast precursors at the inflammation site

  4. Nucleated erythroid cells had high expression of ACKR1, which facilitated their direct contact with hematopoietic stem cells. The absence of erythroid ACKR1 altered mouse hematopoiesis including stem and progenitor cells, which ultimately gave rise to phenotypically distinct neutrophils that readily left the circulation, causing neutropenia.

  5. The DARC/CD234 is expressed on macrophages and stabilizes CD82 on long-term repopulating hematopoietic stem cells, promoting their quiescence.

  6. Ackr1 deficiency appears to be protective in the ApoE knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine expression as well as T-cell subset frequency and inflammatory macrophage content.

  7. the results suggest that normal motor function and behavior may partly depend on negative regulation of Purkinje cell activity by Ackr1.

  8. Darc plays a role in modulating the regulation of inflammatory response to bone injury and that lack of Darc expression promotes cartilage formation in fracture calluses but does not affect bony union or fracture healing at 21 days post-fracture.

  9. The data showed a role for erythrocyte DARC as a chemokine reservoir and that endothelial DARC contributes to the pathogenesis of experimental autoimmune encephalomyelitis by shuttling chemokines across the blood-brain barrier.

  10. DARC is crucial for chemokine-mediated leukocyte recruitment in vivo.

  11. Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion.

  12. Vascular endothelial cells may induce Duffy protein to regulate leukocytes and/or chemokine trafficking

  13. role of the Duffy antigen and glycophorin A as receptors for rodent malaria parasite invasion of erythrocytes

  14. we have defined the binding domain on the mDuffy protein for Plasmodium yoelii binding to erythrocytes

  15. DARC functions to clear angiogenic CXC chemokines from the prostate tumor microcirculation

  16. Darc regulates bone mineral density (BMD)negatively by increasing osteoclast formation. Darc is proposed as a candidate gene for chromosome 1 BMD QTL2.

  17. Results indicate that endothelial cell overexpression of mDARC increased leukocyte trafficking to the tumor, reduced the growth of blood vessels into the tumor, and reduced the growth rate of melanoma.

  18. Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation

  19. renal inflammation developed more rapidly in DARC-deficient mice, without affecting the extent of renal injury at later time points

  20. DARC regulates lung inflammation by controlling the distribution and presentation of chemokines that bind CXCR2.

Cow (Bovine) Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. the 5' flanking region of the DARC gene was isolated and characterized

DARC Antigen Profile

Protein Summary

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DARC

  • Duffy blood group, chemokine receptor (DARC) antibody
  • atypical chemokine receptor 1 (Duffy blood group) (ACKR1) antibody
  • atypical chemokine receptor 1 (Ackr1) antibody
  • atypical chemokine receptor 1 (Duffy blood group) (Ackr1) antibody
  • AA162249 antibody
  • Ackr1 antibody
  • CCBP1 antibody
  • CD234 antibody
  • DARC antibody
  • Dfy antibody
  • ESTM35 antibody
  • FY antibody
  • GPD antibody
  • GpFy antibody
  • WBCQ1 antibody

Protein level used designations for DARC

Duffy blood group, chemokine receptor , duffy antigen/chemokine receptor , Duffy antigen/chemokine receptor , Duffy blood group antigen , Fy glycoprotein , atypical chemokine receptor 1 , glycoprotein D , plasmodium vivax receptor , Duffy antigen receptor for chemokines , blood group antigen , duffy antigen/receptor for chemokine glycoprotein

GENE ID SPECIES
396618 Sus scrofa
478969 Canis lupus familiaris
100398804 Callithrix jacchus
100458473 Pongo abelii
100500770 Papio anubis
2532 Homo sapiens
689105 Rattus norvegicus
13349 Mus musculus
528076 Bos taurus
745985 Pan troglodytes
719284 Macaca mulatta
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