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DNMBP belongs to the DBL (MIM 311030) family of guanine nucleotide exchange factors and plays a role in the regulation of cell junctions (Otani et al., 2006 [PubMed 17015620]).[supplied by OMIM, Mar 2008].. Additionally we are shipping DNMBP Kits (4) and DNMBP Proteins (4) and many more products for this protein.
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The rs3740058 in DNMBP was significantly differently in genotype between Alaheimer diease and control in APOE epsilon4epsilon4 subgroup, but showed no effect on Alzheimer disease risk, either did rs11190305 polymorphisms in DNMBP.
Cdc42 and its specific guanine nucleotide-exchange factor (GEF), Tuba, localize to linear invadosomes, and both are required for linear invadosome formation
Polyproline region of N-WASP is required for the localization of Tuba at the pre-apical patch.
findings underscore a role for DNMBP in the genetic risk for late-onset Alzheimer's disease in the Belgian population
functions to bring together dynamin with actin regulatory proteins
Results confirmed DNMBP may be one of the susceptibility genes for Alzheimer's disease.
Tuba controls the shaping of cell junctions through the local activation of Cdc42 and its effectors.
We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs of Dynamin Binding Protein.
Although DNMBP is an excellent candidate gene because of its role in the APP recycling pathways and being located within a chromosome 10 linkage region, we are unable to confirm that DNMBP is associated with LOAD
Taken together, these results provide evidence that interaction of InlC with host Tuba is important for full virulence.
Tuba-stimulated dorsal ruffling might represent a novel mechanism for the coordination of N-WASP-dependent cytoskeletal rearrangements, and Tuba function is implicated in motility processes.
DNMBP belongs to the DBL (MIM 311030) family of guanine nucleotide exchange factors and plays a role in the regulation of cell junctions (Otani et al., 2006
, dynamin binding protein
, dynamin-binding protein-like
, scaffold protein TUBA
, scaffold protein Tuba