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member of the dynein superfamily expressed in rat brain [RGD, Feb 2006]..
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Pedigree analysis supported the notion that the combination of DNAH1 gene mutations 52430998CCT>C and 52409336C>T and 52428484G>T alone were associated with MMAF. CONCLUSION(S): These DNAH1 gene mutations may be associated with DFS and infertility in the Han population.
This mutation was distinct from previously reported DNAH1 mutations associated with MMAF and only affected the East Asian group. Furthermore, the variant DNAH1 protein could not be detected in spermatozoa by Western blot or immunofluorescence staining although DNAH1 mRNA was expressed in the spermatozoa.
variation in DNAH1 may play a role in primary ciliary dyskinesia
Although DNAH1 is expressed in other ciliated cells, infertility was the only symptom of primary ciliary dyskinesia observed in affected subjects, suggesting that DNAH1 function in cilium is not as critical as in sperm flagellum.
Dynein motor function is important for regulating Gag and viral RNA egress on endosomal membranes in the cytoplasm to directly impact on viral production.
clathrin serving as a regulator of SNX4 (show SNX4 Antibodies)-dependent transport; upon clathrin release, dynein may bind SNX4 (show SNX4 Antibodies) and mediate retrograde movement
These results present a new genetic model for understanding the dynein pathway and its functions during neuronal migration.
Results could find no significant differences or typical disorders in the outer or inner dynein arms of mice deficient in dynein heavy chains.
member of the dynein superfamily expressed in rat brain
dynein, axonemal, heavy chain 1
, dynein, axonemal, heavy polypeptide 1
, dynein, axonemal, heavy polypeptide 1-like
, DNAH1 variant protein
, axonemal beta dynein heavy chain 1
, ciliary dynein heavy chain 1
, dynein heavy chain 1, axonemal
, heat shock regulated 1
, heat shock regulated protein 1
, dynein, axon, heavy chain 1