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Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains.
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Mutations in the genes glucokinase regulatory protein (GCKR), RNase L (RNASEL), leukocyte immunoglobulin-like receptor 3 (LILRA3), and dynein axonemal heavy chain 10 (DNAH10) segregated with elevated HDLc levels in families, while no mutations associated with low HDLc.
Mutation in DNAH10 gene is associated with insulin-resistant cardiometabolic disease.
This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans.
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000
axonemal beta dynein heavy chain 10
, ciliary dynein heavy chain 10
, dynein heavy chain 10, axonemal
, dynein, axonemal, heavy polypeptide 10
, dynein, axonemal, heavy chain 10
, dynein heavy chain 10, axonemal-like
, dynein, axon, heavy chain 10