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E2F6 encodes a member of the E2F transcription factor protein family. Additionally we are shipping E2F6 Antibodies (80) and E2F6 Proteins (3) and many more products for this protein.
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E2F1 (show E2F1 ELISA Kits) forms a protein complex with EBNA3C and E2F6, and EBNA3C competes with E2F1 (show E2F1 ELISA Kits) for E2F6 binding. E2F6 is also recruited by EBNA3C to the E2F1 (show E2F1 ELISA Kits) promoter, which is critical for EBNA3C-mediated cell proliferation.
miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.
Analysis data from a panel of cell cycle transcription factors (E2F1, E2F4, E2F6, and GABPA) finds that a set of core cell cycle genes regulated in both U2OS and HeLa cells are bound by multiple cell cycle transcription factors.
After replication stress, the checkpoint kinase (show ATR ELISA Kits) Chk1 (show CHEK1 ELISA Kits) phosphorylates E2F6, leading to its dissociation from promoters. This promotes E2F (show E2F1 ELISA Kits)-dependent transcription, which mediates cell survival by preventing DNA damage and cell death
findings indicate an inhibitory role of E2F6 in the regulation of IL-13 (show IL13 ELISA Kits) and allergy
E2F6 may recruit BRG1 (show SMARCA4 ELISA Kits) in transcriptional regulation of genes important for G1/S phase transition of the cell cycle.
data suggest that E2F (show E2F1 ELISA Kits)- and Myc (show MYC ELISA Kits)-responsive genes are coregulated by E2F6 complex in quiescent cells
results suggest that E2F6 represses transcription of the brca1, ctip (show RBBP8 ELISA Kits), art27 (show UXT ELISA Kits), hp1alpha (show CBX5 ELISA Kits), and the rbap48 (show RBBP4 ELISA Kits) genes and depletion of E2F6 resulted in the recruitment of E2F1 (show E2F1 ELISA Kits) to the target promoters
contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins
E2F6 does not contain the domains required for modulation of squamous differentiation
These data reveal a novel interplay between the E2F pathway, beta2-adrenergic/PKA/PDE4D, and ERK/c-Src axis in fine tuning the pathological hypertrophic growth response.
E2f6 was similarly bound to the proximal promoter regions both in embryonic stem cells (ESCs (show NR2E3 ELISA Kits)) and epiblast stem cells (EpiSCs)
Data suggest that during development, E2F6 participates in the recruitment of polycomb (show CBX2 ELISA Kits) proteins to specific target promoters.
The 5' untranslated regions of E2F6 and E2F6b are unusually long, and they contain several upstream AUG codons followed by short reading frames. Our results suggest that translation of E2F6b is initiated by internal ribosome entry.
E2F6 is essential for the long-term somatic silencing of certain male-germ-cell-specific genes, but it is dispensable for cell-cycle regulation.
E2F6 silences SMC1beta (show SMC1B ELISA Kits) and STAG3 (show STAG3 ELISA Kits) in somatic cells
This analysis shows that E2f6 and Bmi1 cooperate in the regulation of Hox genes, and consequently axial skeleton development, but not in the repression of the Ink4a-Arf locus.
This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.
E2F transcription factor 6
, transcription factor E2F6
, E2F-binding site-modulating activity protein
, transcriptional repressor E2F6