anti-EF-Hand Domain Family, Member D2 (EFHD2) Antibodies

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity).

list all antibodies Gene Name GeneID UniProt
Anti-Human EFHD2 EFHD2 79180 Q96C19
Anti-Rat EFHD2 EFHD2 298609 Q4FZY0
Anti-Mouse EFHD2 EFHD2 27984  
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Top anti-EF-Hand Domain Family, Member D2 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-EFHD2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Human Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated IHC (p), IHC, ELISA, WB ABIN250320 (0.03µg/ml) staining of Human Thymus lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN250320 (0.3?g/ml) staining of paraffin embedded Human Tonsil. Microwaved antigen retrieval with citrate buffer pH6, HRP-staining. Positive cells A) in the interfollicular area and surrounding a vessel, B) in proximity of the epithelial criptae. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Horse Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Cow Goat Un-conjugated ELISA, IHC, IHC (p), WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185311 (0.1µg/ml) staining of human lymph node lysate. Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185311 (0.3µg/ml) staining of paraffin embedded human tonsil. Microwaved antigen retrieval with citrate buffer pH6, HRP-staining. Positive cells A) in the interfollicular area and surrounding a vessel, B) in proximity of the epithelial criptae. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated IHC, IHC (fro), WB Western Blot: EFHD2 Antibody [NBP1-31134] - Western blot analysis of EFHD2 Antibody on: A:H1299 10% SDS PAGE diluted at 1:1000 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Goat Un-conjugated IHC (p), WB   0.1 mg Log in to see Available
$462.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$446.88
Details

Top referenced anti-EF-Hand Domain Family, Member D2 Antibodies

  1. Human Polyclonal EFHD2 Primary Antibody for IHC (p), IHC - ABIN250320 : Ferrer-Acosta, Rodríguez-Cruz, Orange, De Jesús-Cortés, Madera, Vaquer-Alicea, Ballester, Guinel, Bloom, Vega: EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease. in Journal of neurochemistry 2013 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal EFHD2 Primary Antibody for IHC, ELISA - ABIN185311 : Vuadens, Rufer, Kress, Corthésy, Schneider, Tissot: Identification of swiprosin 1 in human lymphocytes. in Proteomics 2004 (PubMed)
    Show all 3 Pubmed References

More Antibodies against EF-Hand Domain Family, Member D2 Interaction Partners

Human EF-Hand Domain Family, Member D2 (EFHD2) interaction partners

  1. Data demonstrate that EFhd2 shows unique structural and biological features as an EF-hand containing F-actin bundling protein. For F-actin bundling activity, structural stabilization of the EF-hand domains was found to occur in the presence of Ca2 (show CA2 Antibodies)+. The core region of EFhd2 maintains its structure in the absence of Ca2 (show CA2 Antibodies)+ ; however, changes in local conformational flexibility reduce F-actin bundling activity of EFhd2.

  2. Phosphorylation at Ser183 of EFhd2 causes changes in the local conformational dynamics and the surface charge distribution of the actin-binding site, resulting in a re-coordination of the actin-binding sites in the dimer structure.

  3. The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state.

  4. EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia.

  5. Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity.

  6. Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin (show CFL1 Antibodies) through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183

  7. EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration.

  8. the human Shu complex (hSWS1.SWSAP1 (show SWSAP1 Antibodies)) has an evolutionarily conserved function in homologous recombination

  9. Its predominant presence in CD8 (show CD8A Antibodies) lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes.

  10. These results suggest that swiprosin-1 is a PKC-beta (show PRKCB Antibodies) I/eta-inducible gene and it modulates mast cell activation through NF-kappaB (show NFKB1 Antibodies)-dependent pathway.

Mouse (Murine) EF-Hand Domain Family, Member D2 (EFHD2) interaction partners

  1. These results show that EFhd2 is not essential for platelet function in mice indicating that other cytoskeletal adaptors may functionally compensate its loss.

  2. EFhd2 is a neuronal protein that interferes with kinesin-mediated transport.

  3. a role is found for EFhd2 as a negative regulator of germinal center-dependent humoral type 2 immunity, with implications for the generation of IgE.

  4. Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin (show CFL1 Antibodies) through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183

  5. Characterized EFhd2's calcium binding activity. Results showed mutations of a conserved aspartate on either EF-hand motif disrupted calcium binding activity, indicating that these motifs work in pair as a functional calcium binding domain.

  6. EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration.

  7. Swip-1 (show WSB1 Antibodies) provides a membrane scaffold that is required for the Syk (show SYK Antibodies)-, SLP-65 (show BLNK Antibodies)-, and PLCgamma2 (show PLCG2 Antibodies)-dependent BCR (show BCR Antibodies)-induced calcium flux.

  8. study shows that swiprosin-1 may regulate lifespan and BCR (show BCR Antibodies) signaling thresholds in immature B cells

  9. The identification of a novel calcium-binding protein (show GUCA1B Antibodies) associated with tau protein in terminally ill tauopathy mouse model suggests that this association may play an important physiological and/or pathological role.

  10. These results suggest that swiprosin-1 is a PKC-beta (show PRKCB Antibodies) I/eta-inducible gene and it modulates mast cell activation through NF-kappaB (show NFKB1 Antibodies)-dependent pathway.

EF-Hand Domain Family, Member D2 (EFHD2) Antigen Profile

Protein Summary

May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity).

Gene names and symbols associated with EFHD2

  • EF-hand domain family member D2 (EFHD2) antibody
  • EF-hand domain family, member D2 (Efhd2) antibody
  • EF-hand domain family member D2 (efhd2) antibody
  • EF-hand domain family member D2 L homeolog (efhd2.L) antibody
  • EF hand domain containing 2 (Efhd2) antibody
  • EF-hand domain family, member D2 (efhd2) antibody
  • 2600015J22Rik antibody
  • AA408606 antibody
  • D4Wsu27e antibody
  • EFHD2 antibody
  • MGC131292 antibody
  • si:dkey-72l14.9 antibody
  • SWS1 antibody
  • wu:fb80e07 antibody

Protein level used designations for EFHD2

EF hand domain containing 2 , EF hand domain family, member D2 , EF-hand domain-containing protein D2 , swiprosin 1 , swiprosin-1 , EF-hand domain family, member D2

GENE ID SPECIES
79180 Homo sapiens
298609 Rattus norvegicus
430669 Gallus gallus
496711 Xenopus (Silurana) tropicalis
514259 Bos taurus
694155 Macaca mulatta
735013 Xenopus laevis
747200 Pan troglodytes
100345208 Oryctolagus cuniculus
27984 Mus musculus
100380618 Salmo salar
571114 Danio rerio
607254 Canis lupus familiaris
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