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May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity).
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Human Polyclonal EFHD2 Primary Antibody for IHC (p), IHC - ABIN250320
Ferrer-Acosta, Rodríguez-Cruz, Orange, De Jesús-Cortés, Madera, Vaquer-Alicea, Ballester, Guinel, Bloom, Vega: EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease. in Journal of neurochemistry 2013
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Human Polyclonal EFHD2 Primary Antibody for IHC, ELISA - ABIN185311
Vuadens, Rufer, Kress, Corthésy, Schneider, Tissot: Identification of swiprosin 1 in human lymphocytes. in Proteomics 2004
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Data demonstrate that EFhd2 shows unique structural and biological features as an EF-hand containing F-actin bundling protein. For F-actin bundling activity, structural stabilization of the EF-hand domains was found to occur in the presence of Ca2 (show CA2 Antibodies)+. The core region of EFhd2 maintains its structure in the absence of Ca2 (show CA2 Antibodies)+ ; however, changes in local conformational flexibility reduce F-actin bundling activity of EFhd2.
Phosphorylation at Ser183 of EFhd2 causes changes in the local conformational dynamics and the surface charge distribution of the actin-binding site, resulting in a re-coordination of the actin-binding sites in the dimer structure.
The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state.
EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia.
Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity.
Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin (show CFL1 Antibodies) through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183
EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration.
the human Shu complex (hSWS1.SWSAP1 (show SWSAP1 Antibodies)) has an evolutionarily conserved function in homologous recombination
Its predominant presence in CD8 (show CD8A Antibodies) lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes.
These results suggest that swiprosin-1 is a PKC-beta (show PRKCB Antibodies) I/eta-inducible gene and it modulates mast cell activation through NF-kappaB (show NFKB1 Antibodies)-dependent pathway.
These results show that EFhd2 is not essential for platelet function in mice indicating that other cytoskeletal adaptors may functionally compensate its loss.
EFhd2 is a neuronal protein that interferes with kinesin-mediated transport.
a role is found for EFhd2 as a negative regulator of germinal center-dependent humoral type 2 immunity, with implications for the generation of IgE.
Characterized EFhd2's calcium binding activity. Results showed mutations of a conserved aspartate on either EF-hand motif disrupted calcium binding activity, indicating that these motifs work in pair as a functional calcium binding domain.
Swip-1 (show WSB1 Antibodies) provides a membrane scaffold that is required for the Syk (show SYK Antibodies)-, SLP-65 (show BLNK Antibodies)-, and PLCgamma2 (show PLCG2 Antibodies)-dependent BCR (show BCR Antibodies)-induced calcium flux.
study shows that swiprosin-1 may regulate lifespan and BCR (show BCR Antibodies) signaling thresholds in immature B cells
The identification of a novel calcium-binding protein (show GUCA1B Antibodies) associated with tau protein in terminally ill tauopathy mouse model suggests that this association may play an important physiological and/or pathological role.
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance (By similarity).
EF hand domain containing 2
, EF hand domain family, member D2
, EF-hand domain-containing protein D2
, swiprosin 1
, EF-hand domain family, member D2