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EGFL7 encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. Additionally we are shipping EGFL7 Antibodies (72) and EGFL7 Kits (19) and many more products for this protein.
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Human EGFL7 Protein expressed in Wheat germ - ABIN1352429
Badiwala, Guha, Tumiati, Joseph, Ghashghai, Ross, Delgado, Rao: Epidermal growth factor-like domain 7 is a novel inhibitor of neutrophil adhesion to coronary artery endothelial cells injured by calcineurin inhibition. in Circulation 2011
Show all 2 Pubmed References
we demonstrate for the first time the mechanisms by which lumens are generated within the major vessels in Xenopus and implicate EGFL7 in modulating cell shape and cell-cell junctions to drive proper lumen morphogenesis.
CASZ1/Egfl7/RhoA (show RHOA Proteins) pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
These data suggest that Egfl7 provides endothelial cells (EC) with a cue for their extension into the vascular area and in establishing EC cell polarity.
EGFL7 provides a proper microenvironment for endothelial cell migration, thereby enabling accurate patterning.
Egfl7 is crucial for placental vascularization and embryonic growth.
the angiogenic factor (show VEGFA Proteins) Egfl7 activates the Flt3/Flt3 (show FLT3 Proteins) ligand (show FLT3LG Proteins) pathway and is a key molecular driver enforcing thymus progenitor generation and thereby directly links endothelial cell biology to the production of T cell-based adaptive immunity
EGFL7 is required for VEGF (show VEGFA Proteins) upregulation of the Akt (show AKT1 Proteins)/Erk (1 (show MAPK3 Proteins)/2) pathway during angiogenesis.
EGFL7 enhances EGFR (show EGFR Proteins)-AKT (show AKT1 Proteins) signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells.
Egfl7 could be a HIF-1alpha (show HIF1A Proteins) responsive gene regulated by oxygen tension.
Using the BPH/5 model of pre-eclampsia (PE), we show that the downregulation of Egfl7 in compromised placentas occurs pr (show NOTCH1 Proteins)ior to the onset of characteristic maternal signs of PE.
egfl7 is initially expressed in all endothelial cells and then is progressively restricted to veins and to their neighbouring capillaries.
EGFL7 is expressed in the bone microenvironment and has a role in promoting endothelial cell migration and tube-like structure formation through integrin-mediated pathways.
Expression of Egfl7 in breast and lung carcinoma cells accelerates tumor growth and metastasis in immunocompetent mice but not in immunodeficient mice.
Overexpression of endothelial Egfl7 is associated with impaired angiogenesis and altered Notch (show NOTCH1 Proteins) signaling
This phase II trial evaluated the efficacy of parsatuzumab (also known as MEGF0444A), a humanized anti-EGFL7 IgG1 monoclonal antibody, in combination with modified FOLFOX6 (mFOLFOX6) (folinic acid, 5-fluorouracil, and oxaliplatin) bevacizumab in patients with previously untreated metastatic colorectal cancer
Oncogenic activation of EGFRwt in GBM is likely maintained by a continuous EGFL7 autocrine flow line.
our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis
Egfl7 is thus an endogenous and constitutive repressor of blood vessel endothelial cell activation in normal and inflammatory conditions and participates in a loop of regulation of activation of these cells by pro-inflammatory cytokines.
Up-regulated MALAT1 promoted the invasion and metastasis of GC, and the increase of EGFL7 expression was a potential mechanism via altering its H3 histone (show HIST1H3B Proteins) acetylation level
These findings suggest that the stimulating effect of EGFL7-ESCs (show NR2E3 Proteins) on fibroblast proliferation and migration may provide a useful strategy for wound healing.
A gene expression study was conducted to investigate the levels of Egfl7 and miRNA126-5p in human carotid artery atherosclerotic plaques
By regulating endothelial cell adhesion, EGFL7 plays a key role in the regulation of glioma angiogenesis.
The preferential expression of EGFL7 in less differentiated hepatocellular carcinoma compared to VEGF (show VEGFA Proteins), suggests a possible important role of this angiogenic factor (show VEGFA Proteins) in a later oncogenic and infiltrative/metastatic phase.
EGFR (show EGFR Proteins) mutational analysis is useful in the diagnosis of non-small-cell-lung cancer.
This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants.
EGF-like-domain, multiple 7
, epidermal growth factor-like protein 7
, EGF-like protein 7
, NEU1 protein
, NOTCH4-like protein
, multiple EGF-like domains protein 7
, multiple epidermal growth factor-like domains protein 7
, vascular endothelial statin
, vascular endothelial-statin
, EGF-like domain 7
, EGF-like domain-containing protein 7
, Estrogen-regulated protein CBL20 20.4kD
, Estrogen-regulated protein CBL20, 20.4kD
, multiple EGF-like domain protein 7
, multiple epidermal growth factor-like domain protein 7