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The protein encoded by ERC1 is a member of a family of RIM-binding proteins. Additionally we are shipping ERC1 Antibodies (42) and ERC1 Proteins (5) and many more products for this protein.
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The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility.
ELKS removal has differential, synapse-specific effects on readily releasable vesicles and probability of release, and findings establish important roles for ELKS N-terminal domains in synaptic vesicle priming.
Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge
a new, but rare, antigen in Lambert-Eaton myasthenic syndrome
ATM- and NEMO-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1/TAB2/3 and NEMO/IKK complexes, resulting in IKK and NF-kappaB activation following genotoxic stimuli.
Analysis of the gene structure of four isoforms (ELKS beta, ELKS gamma, ELKS delta, and ELKS epsilon) in a case of papillary thyroid carcinoma reveal that the isoforms are produced by alternative splicing.
In vitro results indicate that ERC2/CAST, an active zone-specific isoform, interacts with all of the known isoforms of liprin-alpha and that liprin-alpha1 associates with both ERC2 and ERC1b
ELKS likely functions by recruiting IkappaBalpha to the IkappaB kinase (IKK) complex and thus serves a regulatory function for IKK activation
ERC1-PDGFRB fusion is associated with acute myeloid leukemia
SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome.
Our results reveal that ELKS is required for normal Ca(2+) influx at nerve terminals of inhibitory hippocampal neurons.
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10\;12)(q11\;p13). Multiple transcript variants encoding different isoforms have been found for this gene.
ELKS/RAB6-interacting/CAST family member 1
, RAB6-interacting protein 2
, ELKS/RAB6-interacting/CAST family member 1-like
, ELKS/Rab6-interacting/CAST family member 1-like
, ELKS/Rab6-interacting/CAST family member 1
, RAB6 interacting protein 2
, Rab6-interacting protein 2
, CAZ-associated structural protein 2
, Rab6 interacting protein 2
, ERC protein 1
, RIM-Binding Protein