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The protein encoded by ERC1 is a member of a family of RIM-binding proteins. Additionally we are shipping ERC1 Antibodies (42) and ERC1 Proteins (5) and many more products for this protein.
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ELKS removal has differential, synapse-specific effects on readily releasable vesicles and probability of release, and findings establish important roles for ELKS N-terminal domains in synaptic vesicle priming.
Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge
ATM (show ATM ELISA Kits)- and NEMO (show IKBKG ELISA Kits)-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1 (show MAP3K7 ELISA Kits)/TAB2 (show TAB2 ELISA Kits)/3 and NEMO (show IKBKG ELISA Kits)/IKK (show CHUK ELISA Kits) complexes, resulting in IKK (show CHUK ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) activation following genotoxic stimuli.
Analysis of the gene structure of four isoforms (ELKS beta, ELKS gamma, ELKS delta, and ELKS epsilon) in a case of papillary thyroid carcinoma reveal that the isoforms are produced by alternative splicing.
In vitro results indicate that ERC2/CAST, an active zone-specific isoform, interacts with all of the known isoforms of liprin-alpha and that liprin-alpha1 associates with both ERC2 and ERC1b
ELKS likely functions by recruiting IkappaBalpha (show NFKBIA ELISA Kits) to the IkappaB kinase (show CHUK ELISA Kits) (IKK (show CHUK ELISA Kits)) complex and thus serves a regulatory function for IKK (show CHUK ELISA Kits) activation
ERC1-PDGFRB (show PDGFRB ELISA Kits) fusion is associated with acute myeloid leukemia (show BCL11A ELISA Kits)
SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2 (show RABEP2 ELISA Kits), ERC1), and with non-muscle myosin motor proteins (MYH9 (show MYH9 ELISA Kits), MYH10 (show MYH10 ELISA Kits), MYH14) at the centrosome.
Our results reveal that ELKS is required for normal Ca(2 (show CA2 ELISA Kits)+) influx at nerve terminals of inhibitory hippocampal neurons.
ATM (show ATM ELISA Kits)- and NEMO (show IKBKG ELISA Kits)-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1 (show NR2C2 ELISA Kits)/TAB2 (show TAB2 ELISA Kits)/3 and NEMO (show IKBKG ELISA Kits)/IKK (show CHUK ELISA Kits) complexes, resulting in IKK (show CHUK ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) activation following genotoxic stimuli.
The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10\;12)(q11\;p13). Multiple transcript variants encoding different isoforms have been found for this gene.
ELKS/RAB6-interacting/CAST family member 1
, RAB6-interacting protein 2
, ELKS/RAB6-interacting/CAST family member 1-like
, ELKS/Rab6-interacting/CAST family member 1-like
, ELKS/Rab6-interacting/CAST family member 1
, RAB6 interacting protein 2
, Rab6-interacting protein 2
, CAZ-associated structural protein 2
, Rab6 interacting protein 2
, ERC protein 1
, RIM-Binding Protein