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Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Additionally we are shipping EID1 Antibodies (35) and and many more products for this protein.
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EID1 can modulate adipose mesenchymal stem cells, inducing a brown/beige lineage.
SCF(FBXO21) polyubiquitylates EID1 both in vitro and in vivo and is required for the efficient degradation of EID1 in both cycling and quiescent cells.
The results suggest that EID1 is a bona fide substrate of FBXO21 and that the control of EID1 abundance by SCF(FBXO)(21) might affect the transcriptional repression activity of EID1.
Pcid2 is present in the CBP/p300-EID1 complex to control the switch balance of mouse and human embryonic stem cells through modulation of EID1 degradation.
An unexpected EID1-binding site on SHP is located at the N terminus of the receptor, where EID1 mimics helix H1 of the nuclear receptor ligand-binding domain.
This study demonstrated that overexpression of EID1 reduced hippocampal long-term potentiation and impaired spatial learning and memory function in the transgenic mice
miR-138 inhibited adipogenesis through targeting the nuclear receptor coregulator EID-1
The role of EID1 in fibroblast biology and fibrosis is reported.
Repression of E6 and E7 oncogenes results in restoration of pRb suppressor pathways and induced apoptosis in HPV16-positive oropharyngeal squamous cell cancer cell lines.
palmitoylation modified E1A-like inhibitor of differentiation one (EID1) and this modification regulated EID1 degradation and CREB-binding protein (CBP)/p300 histone acetyltransferase activity at the switch between self-renewal and differentiation of neural stem cells.
This study supports Cri1 as the major locus controlling susceptibility following murine infection with C. rodentium, and suggests a cause of mortality common to the susceptible C3, C3Ou and FVB strains of mice.
Cri1 does not control C. rodentium colonic hyperplasia
isolation of mouse E1A-like inhibitor of differentiation 1 (EID1) as a candidate coinhibitor for SHP
EID-1 is expressed in the mouse testis, and its expression decreases during testis development. The results of the present study suggest that EID-1 can act as a repressor, regulating the function of SF-1.
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms (By similarity).
CREBBP/EP300 inhibitor 1
, 21 kDa pRb-associated protein
, CREBBP/EP300 inhibitory protein 1
, E1A-like inhibitor of differentiation 1
, EP300-interacting inhibitor of differentiation 1
, NB4 apoptosis related protein
, Rb- and p300-binding protein EID-1
, retinoblastoma protein-associated protein