ER Lipid Raft Associated 2 Proteins (ERLIN2)

ERLIN2 encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. Additionally we are shipping ERLIN2 Antibodies (67) and ERLIN2 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ERLIN2 11160 O94905
ERLIN2 290823 B5DEH2
ERLIN2 244373 Q8BFZ9
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Top ERLIN2 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human ERLIN2 Protein. 100 μg Log in to see 11 to 18 Days
$653.82
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,889.33
Details
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$2,893.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 60 to 71 Days
$2,905.83
Details

ERLIN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
,

More Proteins for ER Lipid Raft Associated 2 (ERLIN2) Interaction Partners

Pig (Porcine) ER Lipid Raft Associated 2 (ERLIN2) interaction partners

  1. swine erlin2 gene has a closer genetic relationship with the erlin2 genes of human and rhesus monkey. This gene is differentially expressed in the liver tissues from Meishan and Large White pigs.

Human ER Lipid Raft Associated 2 (ERLIN2) interaction partners

  1. Biallelic variants in ERLIN2 are known to cause recessive HSP type SPG18. Here, the first two families with an autosomal dominant, pure form of HSP caused by a novel ERLIN2 heterozygous missense variant are described. These findings expand the mutational and inheritance spectrum of SPG18.

  2. Here we suggest that ERLIN1 variants, previously shown in juvenile hereditary spastic paraplegia cases, may also be the cause of a slowly progressive early-onset Amyotrophic lateral sclerosis (ALS) , starting with upper motor neuron features and developing into classical ALS with the addition of lower motor neuron dysfunction.

  3. Novel Mutations in Endoplasmic Reticulum Lipid Raft-associated Protein 2 Gene Cause Pure Hereditary Spastic Paraplegia Type 18

  4. Here we show that the multimeric ER proteins erlins-1 and -2 are additional sterol regulatory element binding protein regulators.

  5. ERLIN2 was found to be responsible for causing hereditary spastic paraplegia in a Saudi family.

  6. ERLIN2 may confer a selective growth advantage for breast cancer cells by facilitating a cytoprotective response to various cellular stresses associated with oncogenesis.

  7. ERLIN2 loss on cell growth may advance understanding of the mechanism behind motor neuron degeneration in primary lateral sclerosis

  8. a novel brain gamma-secretase associated protein , erlin-2, that resides in detergent resistant membranes and affects amyloid beta-peptide production.

  9. a novel role for ERLIN2 in supporting cancer cell growth by promoting the activation of the key lipogenic regulator SREBP1c and the production of cytosolic lipid droplets.

  10. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.

  11. study describes an extended consanguineous Saudi family in which hereditary spastic paraplegia is linked to SPG18, an autosomal recessive locus, and show it is associated with a nullimorphic deletion of ERLIN2

  12. The gene encodes endoplasmic reticulum (ER) lipid raft-associated protein 2 that mediates the ER-associated degradation of activated inositol 1,4,5-trisphosphate receptors and other substrates.

  13. Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER.

  14. SPFH2 as a key endoplasmic reticulum associated degradation pathway component and suggest that it may act as a substrate recognition factor.

  15. Results suggest that this novel SPFH1/2 complex is a recognition factor that targets IP(3)Rs and perhaps other substrates for ERAD.

  16. m3 receptor-expressing HeLa cells are a valuable system for studying IP(3) receptor ERAD, and suggest that the SPFH1/2 complex is a factor that selectively mediates the ERAD of activated IP(3) receptors.

Mouse (Murine) ER Lipid Raft Associated 2 (ERLIN2) interaction partners

  1. The erlin2 threonine to isoleucine 65 substitution inhibits erlin1/erlin2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding.

  2. 2 MDa erlin1/2 complex is composed of an assemblage of lower-order hetero-oligomers, probably heterotrimers, linked together by assembly domain hydrophobic residues.

ERLIN2 Protein Profile

Protein Summary

This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with ERLIN2

  • ER lipid raft associated 2 (ERLIN2)
  • erlin-2 (Tsp_03442)
  • Erlin-2 (erln2)
  • ER lipid raft associated 2 (Erlin2)
  • ER lipid raft associated 2 (erlin2)
  • BC036333 protein
  • C8orf2 protein
  • C87251 protein
  • Erlin-2 protein
  • NET32 protein
  • RGD1309010 protein
  • Spfh2 protein
  • SPG18 protein

Protein level used designations for ERLIN2

erlin-2 , ER lipid raft associated 2 , erlin-2-like , Erlin-2 , SPFH domain family, member 2 , endoplasmic reticulum lipid raft-associated protein 2 , stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 , SPFH domain-containing protein 2

GENE ID SPECIES
100233180 Sus scrofa
464112 Pan troglodytes
607518 Canis lupus familiaris
100223235 Taeniopygia guttata
100354383 Oryctolagus cuniculus
100468740 Ailuropoda melanoleuca
10909428 Trichinella spiralis
100380304 Salmo salar
11160 Homo sapiens
290823 Rattus norvegicus
244373 Mus musculus
616278 Bos taurus
426769 Gallus gallus
100151163 Danio rerio
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